N-Terminal Targeting of Regulator of G Protein Signaling Protein 2 for F-Box Only Protein 44–Mediated Proteasomal Degradation

McNabb, Harrison J.; González, Stephanie; Muli, Christine S.; Sjögren, Benita

doi:10.1124/molpharm.120.000061

Cited by 5 publications

(2 citation statements)

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“…However, FBXO44 is only capable of targeting RGS2 for ubiquitination in the context of CUL4B but not CUL1 [140]. The RGS2-FBXO44 interaction can be regulated by phosphorylation, and the phosphorylation of Ser 3 on RGS2 could protect RGS2 from degradation through reducing its binding with FBXO44 [145]. Since low RGS2 protein level is associated with disease such as hypertension and heart failure, drugs that interfere with the RGS2-FBXO44 interaction can be beneficial for preventing cardiovascular diseases [145].…”

Section: Non-canonical Crl4s Involved In Cardiovascular Diseasesmentioning

confidence: 99%

Roles of Cullin-RING Ubiquitin Ligases in Cardiovascular Diseases

et al. 2022

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Maintenance of protein homeostasis is crucial for virtually every aspect of eukaryotic biology. The ubiquitin-proteasome system (UPS) represents a highly regulated quality control machinery that protects cells from a variety of stress conditions as well as toxic proteins. A large body of evidence has shown that UPS dysfunction contributes to the pathogenesis of cardiovascular diseases. This review highlights the latest findings regarding the physiological and pathological roles of cullin-RING ubiquitin ligases (CRLs), an essential player in the UPS, in the cardiovascular system. To inspire potential therapeutic invention, factors regulating CRL activities are also discussed.

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Section: Non-canonical Crl4s Involved In Cardiovascular Diseasesmentioning

confidence: 99%

Roles of Cullin-RING Ubiquitin Ligases in Cardiovascular Diseases

et al. 2022

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“…Regulators of G protein signaling (RGS) are a group of regulator proteins of G protein‐coupled receptors. RGS proteins are accelerator proteins of GTPase, which turn off the signal transduction of Gα and βγ of G protein and negatively regulate G protein signaling (McNabb et al., 2020; Senese et al., 2020). So far, there are more than 20 RGS proteins, which are abundantly expressed in many brain regions that mediate addiction and analgesia.…”

Section: Introductionmentioning

confidence: 99%

The roles of ubiquitin–proteasome system and regulator of G protein signaling 4 in behavioral sensitization induced by a single morphine exposure

et al. 2023

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Aims Opioid addiction is a major public health issue, yet its underlying mechanism is still unknown. The aim of this study was to explore the roles of ubiquitin–proteasome system (UPS) and regulator of G protein signaling 4 (RGS4) in morphine‐induced behavioral sensitization, a well‐recognized animal model of opioid addiction. Methods We explored the characteristics of RGS4 protein expression and polyubiquitination in the development of behavioral sensitization induced by a single morphine exposure in rats, and the effect of a selective proteasome inhibitor, lactacystin (LAC), on behavioral sensitization. Results Polyubiquitination expression was increased in time‐dependent and dose‐related fashions during the development of behavioral sensitization, while RGS4 protein expression was not significantly changed during this phase. Stereotaxic administration of LAC into nucleus accumbens (NAc) core inhibited the establishment of behavioral sensitization. Conclusion UPS in NAc core is positively involved in behavioral sensitization induced by a single morphine exposure in rats. Polyubiquitination was observed during the development phase of behavioral sensitization, while RGS4 protein expression was not significantly changed, indicating that other members of RGS family might be substrate proteins in UPS‐mediated behavioral sensitization.

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Palmitoylation of RGS20 affects Gαo-mediated signaling independent of its GAP activity

Zhang

Sjögren

2023

Cellular Signalling

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N-Terminal Targeting of Regulator of G Protein Signaling Protein 2 for F-Box Only Protein 44–Mediated Proteasomal Degradation

Cited by 5 publications

References 43 publications

Roles of Cullin-RING Ubiquitin Ligases in Cardiovascular Diseases

Roles of Cullin-RING Ubiquitin Ligases in Cardiovascular Diseases

The roles of ubiquitin–proteasome system and regulator of G protein signaling 4 in behavioral sensitization induced by a single morphine exposure

Palmitoylation of RGS20 affects Gαo-mediated signaling independent of its GAP activity

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