HIGHLIGHTS mGluR5-D1-CB1-induced eCB-LTD mediates drugs of abuse and natural reward seeking eCB-LTD in D2-MSNs plays no important role in processing of rewardseeking responses Loss of eCB-LTD is a consequence of higher MAGL activity and lower CB1R expression Acute drug administration stops craving for alternative rewards on following days
Teleseismic tomography across the Chinese Tien Shan shows that seismic wave speeds in the lithosphere beneath central Tien Shan are high and therefore the lithosphere is not weaker than that beneath the adjacent undeformed Tarim and Junggar basins. There is evidence for significant velocity contrasts within the lithosphere that are presumably inherited from the Palaeozoic collision history. The high‐velocity, thick Yili block observed underneath the northern Tien Shan is a clue for shortening by a intracontinental subduction. The observed geometry is consistent with a simple model of intracontinental subduction and suggests that, during orogeny, the lithosphere has remained heterogeneous and has deformed along existing planes of weakness rather than by homogeneous thickening of a particularly weak lithosphere.
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