N-3 polyunsaturated fatty acids prevent the <scp>d</scp>-galactose-induced cognitive impairment by up-regulating the levels of 5-hydroxymethylcytosine in the mouse brain

Zhang, Tianyu; Chen, Lei; Guo, Xiaofei; Li, Shan; He, Xin; Pei, Shengjie; Li, Duo

doi:10.1039/d1fo04420f

Cited by 8 publications

(3 citation statements)

References 40 publications

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“…The increase in the RI was also observed in the D-Gal-induced aging rats-treated with PEP extract at doses of 250 and 500 mg/kg when compared with the aging model group; however, these differences did not show statistical significance (p > 0.05). Consistent with other studies [36,37], we found that the impairment of recognition memory was induced by D-Gal, resulting in a reduction of the RI as observed in the NOR test, while PEP extract (500 mg/kg) as well as DNP treatment abolished the amnestic effect of D-Gal.…”

Section: Effects Of Eggplant Extract On Learning and Memory Performancesupporting

confidence: 92%

“…However, when present at high levels, it has the potential to induce the accumulation of ROS, leading to oxidative stress and subsequent cellular damage [31]. Many studies have reported that chronic administration of D-Gal cause cognitive deficits, which are mediated through various mechanisms in the brain, including oxidative stress [32][33][34][35], inflammation [32,33,35], cholinergic dysfunction [35], mitochondrial dysfunction [34,36], AGEs accumulation [33]. The hippocampus is a complex structure within the temporal lobe.…”

Section: Effects Of Eggplant Extract On Learning and Memory Performancementioning

confidence: 99%

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Purple Eggplant (Solanum melongena L.) Ameliorates D-Galactose-Induced Cognitive Impairment Through Inhibition of Oxidative Stress and Acetylcholinesterase in the Hippocampus of an Aging Rat Model

Jeefoo,

Phachonpai,

Duangjai

et al. 2023

Trends Sci

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The induction of neurotoxicity by d-galactose (D-Gal) is a widely recognized model that is utilized for investigating the process of aging and the associated cognitive impairment, as well as oxidative damage and cholinergic dysfunction. Eggplant fruit is a highly consumed vegetable owing to its high phenolic content, which exhibits antioxidant properties. The current investigation aimed to assess the effect of an aqueous extract of Thai purple eggplant (PEP) fruit (Solanum melongena L., ‘Ma Khuea Muang’) on memory impairment and explore the underlying mechanisms. The quantification of total phenolic contents was conducted on the PEP extract, and an analysis of its antioxidant activity was performed using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2-Azino-bis (3-ethyl benzothiazoline-6-sufonic acid) (ABTS) scavenging assays. Male Wistar rats were subcutaneously (s.c.) injected (150 mg/kg/day) with D-Gal to generate a model of accelerated aging and administered orally with EP extract (250, 500, and 1,000 mg/kg/day) or donepezil (DNP) (3 mg/kg/day) for 8 weeks. Cognitive performance was evaluated by the Morris water maze (MWM) and novel object recognition (NOR) tests. Malondialdehyde (MDA) level and acetylcholinesterase (AChE) and superoxide dismutase (SOD) activities in the hippocampus were also evaluated after the behavioral studies. The continuous administration of PEP extract at a dosage of 1,000 mg/kg/day or DNP resulted in the amelioration of cognitive impairment and the reversal of the increase in AChE activity caused by D-Gal in the hippocampus. Furthermore, the administration of PEP extract resulted in a significant reduction in MDA levels in the hippocampus. These findings suggest a potential attenuation of oxidative stress. The findings indicate that the PEP extract has a beneficial effect on cognitive decline induced by D-Gal, which is attributed to the restoration of cholinergic function and the reduction of oxidative damage. HIGHLIGHTS In D-galactose-induced aged rats, purple eggplant (Solanum melongena) (PEP) extract can inhibit elevated acetylcholinesterase (AChE) activity and malondialdehyde (MDA) levels in the hippocampus. The consumption of PEP extract has been found to have potential benefits in improving age-related learning and memory impairment. The utilization of PEP extract as a dietary supplement may serve as a viable option for the elderly population in the prevention of dementia. GRAPHICAL ABSTRACT

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Section: Effects Of Eggplant Extract On Learning and Memory Performancesupporting

confidence: 92%

Section: Effects Of Eggplant Extract On Learning and Memory Performancementioning

confidence: 99%

Purple Eggplant (Solanum melongena L.) Ameliorates D-Galactose-Induced Cognitive Impairment Through Inhibition of Oxidative Stress and Acetylcholinesterase in the Hippocampus of an Aging Rat Model

Jeefoo,

Phachonpai,

Duangjai

et al. 2023

Trends Sci

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“…8 Edible oils are an essential part of our daily lives, and their intake plays a very important role in people's health. It has also been confirmed that the intake of oils rich in polyunsaturated fatty acids (such as walnut oil, 9 camellia oil, 10 olive oil 11 and peony seed oil 12 ) could significantly prevent and mitigate the onset of neurodegenerative diseases or neuroinflammatory conditions, including AD. 13 This is because polyunsaturated fatty acids can improve cognitive impairment or neuronal deficits by promoting neuronal growth.…”

Section: Introductionmentioning

confidence: 97%

Gut microbiome and brain transcriptome analyses reveal the effect of walnut oil in preventing scopolamine-induced cognitive impairment

Zheng,

Kang,

Jiang

et al. 2023

Food Funct.

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The consumption of lard oil during pregnancy and postpartum periods has negative effects on cognitive function by altering the fatty acid profile and activating neuroinflammation via calcium signaling pathway in the maternal mice brain

Shi,

Tian,

Zhang

et al. 2024

Current Research in Food Science

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N-3 polyunsaturated fatty acids prevent the d-galactose-induced cognitive impairment by up-regulating the levels of 5-hydroxymethylcytosine in the mouse brain

Abstract: Decreased 5-hydroxymethylcytosine (5hmC) levels caused by mitochondrial dysfunction in brain are closely associated with the development of neurodegenerative disease. It has been reported that n-3 polyunsaturated fatty acids (PUFA) prevent...

Cited by 8 publications

References 40 publications

Purple Eggplant (Solanum melongena L.) Ameliorates D-Galactose-Induced Cognitive Impairment Through Inhibition of Oxidative Stress and Acetylcholinesterase in the Hippocampus of an Aging Rat Model

Purple Eggplant (Solanum melongena L.) Ameliorates D-Galactose-Induced Cognitive Impairment Through Inhibition of Oxidative Stress and Acetylcholinesterase in the Hippocampus of an Aging Rat Model

Gut microbiome and brain transcriptome analyses reveal the effect of walnut oil in preventing scopolamine-induced cognitive impairment

The consumption of lard oil during pregnancy and postpartum periods has negative effects on cognitive function by altering the fatty acid profile and activating neuroinflammation via calcium signaling pathway in the maternal mice brain

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