Gut microbiome and brain transcriptome analyses reveal the effect of walnut oil in preventing scopolamine-induced cognitive impairment

Zheng, Jing Yi; Kang, Ting; Jiang, Chao; Lin, Li Ke; Gao, Lu; Jin, Li Hua; Shu, Yu; Zhang, Jing Jing; Li, Cong; Chen, Bang; Shen, Ye Hua

doi:10.1039/d3fo01893h

Cited by 3 publications

(2 citation statements)

References 55 publications

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“…The Morris water maze (MWM) test was carried out on the 8th week, based on a previously method with slight modifications. 15 The MWM devices equipped with a black circular pool (diameter: 120 cm; height: 50 cm), a platform (diameter: 10 cm) placed 1 cm below the water surface, a tracking camera and a computer connected to the camera. The pool was filled with water and the temperature was 22–24 °C.…”

Section: Methodsmentioning

confidence: 99%

“…Dietary supplementation with WO has been shown to improve the prevention of scopolamine-induced cognitive behavioral deficits and synaptic dysfunction in mice by modulating the gut microbiota and affecting neurotransmitters. 15 PSO has also proved to improve neuroinflammation-mediated cognitive impairment in mice by inhibiting microglia activation through the NF-κB pathway. 16 CSO, which is rich in oleic acid, have also been shown to have neuroprotective effects on AlCl 3 -induced mild cognitive impairment in rats.…”

Section: Introductionmentioning

confidence: 99%

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Amelioration of walnut, peony seed and camellia seed oils against d-galactose-induced cognitive impairment in mice by regulating gut microbiota

Kang,

Zheng,

Jiang

et al. 2024

Food Funct.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Amelioration of walnut, peony seed and camellia seed oils against d-galactose-induced cognitive impairment in mice by regulating gut microbiota

Kang,

Zheng,

Jiang

et al. 2024

Food Funct.

Self Cite

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Lipidomics and metabolomics reveal the molecular mechanisms underlying the effect of thermal treatment on composition and oxidative stability of walnut oil

Zhang,

Xu,

Zeng

et al. 2024

Food Research International

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Edible plant oils modulate gut microbiota during their health-promoting effects: a review

Zou,

Chen,

Huang

et al. 2024

Front. Nutr.

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Edible plant oils are widely used in cooking, cosmetics, health supplement capsules, and other industries, due to their various health-promoting effects. There is increasing evidence that edible plant oils can modulate gut microbiota during their health-promoting effects in animal experiments and cohort or clinical studies. However, the information concerning the gut microbiota modulation of edible plant oils during their health-promoting effects is scattered. In this article, the research progress on gut microbiota modulation of edible plant oils (especially camellia oil, olive oil, and flaxseed oil) is summarized. Meanwhile, a summary on correlations between modulated gut microbiota and changed biochemical indexes is provided. The alterations of edible plant oils on gut microbiota-derived metabolites and the correlations between altered metabolites and modulated gut microbiota as well as changed biochemical indexes are reviewed. Furthermore, the prospects for gut microbiota modulation of edible plant oils during their health-promoting effects are put forward. Existing literature has shown that edible plant oils could modulate gut microbiota during their health-promoting effects, and some differential gut microbiota biomarkers were gained. Some similarities and differences existed while the oils exhibited health-promoting actions. Dosage and treatment time have influences on gut microbiota modulation of edible plant oils. Different edible plant oils exhibited different behaviors in modulating gut microbiota, and edible plant oils were mostly different in modulating gut microbiota compared to edible animal oils. Moreover, the modulated gut microbiota was significantly correlated with the changed biochemical indexes. Furthermore, edible plant oils altered SCFAs and other gut microbiota-derived metabolites. The altered metabolites were obviously correlated with the modulated gut microbiota and changed biochemical indexes. This review is helpful to the future research and application of edible plant oils in health-promoting effects from the perspective of gut microbiota.

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Gut microbiome and brain transcriptome analyses reveal the effect of walnut oil in preventing scopolamine-induced cognitive impairment

Abstract: Walnut oil could improve cognitive impairment by influencing the secretion of neurotransmitters through the regulation of gut microbiota in vivo.

Cited by 3 publications

References 55 publications

Amelioration of walnut, peony seed and camellia seed oils against d-galactose-induced cognitive impairment in mice by regulating gut microbiota

Amelioration of walnut, peony seed and camellia seed oils against d-galactose-induced cognitive impairment in mice by regulating gut microbiota

Lipidomics and metabolomics reveal the molecular mechanisms underlying the effect of thermal treatment on composition and oxidative stability of walnut oil

Edible plant oils modulate gut microbiota during their health-promoting effects: a review

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