Myoinositol: The Bridge (PONTI) to Reach a Healthy Pregnancy

Cavalli, Pietro; Ronda, Elena

doi:10.1155/2017/5846286

Cited by 14 publications

(12 citation statements)

References 28 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The efficacy of folic acid has been replicated in a series of further intervention trials ( 112 ), with compelling evidence that maternal intake of folic acid supplements in the periconceptional period significantly reduces NTD risk ( 117 ), with prevention also achieved by folic acid fortification of flour ( 118 ). Clinical case studies have therefore drawn attention to a subset of NTDs (∼30%) referred to be as “folic acid resistant” NTDs ( 4 , 119 , 120 ) that occur despite the use of folic acid in the periconceptional period.…”

Section: Folate Inositol and Ntds—evidence For Folate-sensitive Andmentioning

confidence: 99%

“…Further, a lower maternal myo -inositol concentration in humans is associated with a greater risk of having a spina bifida–affected infant ( 29 ). Such observations led to the use of myo -inositol in a highly selected group of women to prevent NTD recurrence in a subsequent pregnancy ( 119 – 121 ). A cohort of 12 women with a history of folic acid–resistant NTDs, who were counseled to take a combination of myo -inositol and folic acid supplements before a subsequent pregnancy, gave birth to healthy infants without NTDs ( 119 – 121 ).…”

Section: Folate Inositol and Ntds—evidence For Folate-sensitive Andmentioning

confidence: 99%

See 1 more Smart Citation

Maternal Inositol Status and Neural Tube Defects: A Role for the Human Yolk Sac in Embryonic Inositol Delivery?

D'Souza

Copp

Greene

et al. 2021

Advances in Nutrition

View full text Add to dashboard Cite

Supplementation with myo-inositol during the periconceptional period of pregnancy may ameliorate the recurrence risk of having a fetus affected by a neural tube defect (NTD; e.g., spina bifida). This could be of particular importance in providing a means for preventing NTDs that are unresponsive to folic acid. This review highlights the characteristics of inositol and describes the role of myo-inositol in the prevention of NTDs in rodent studies and the evidence for its efficacy in reducing NTD risk in human pregnancy. The possible reduction in NTD risk by maternal myo-inositol implies functional and developmentally important maternal–embryonic inositol interrelationships and also suggests that embryonic uptake of myo-inositol is crucial for embryonic development. The establishment of active myo-inositol cellular uptake mechanisms in the embryonic stages of human pregnancy, when the neural tube is closing, is likely to be an important determinant of normal development. We draw attention to the generation of materno-fetal inositol concentration gradients and relationships, and outline a transport pathway by which myo-inositol may be delivered to the early developing human embryo. These considerations provide novel insights into the mechanisms that may underpin inositol's ability to confer embryonic developmental benefit.

show abstract

Section: Folate Inositol and Ntds—evidence For Folate-sensitive Andmentioning

confidence: 99%

Section: Folate Inositol and Ntds—evidence For Folate-sensitive Andmentioning

confidence: 99%

Maternal Inositol Status and Neural Tube Defects: A Role for the Human Yolk Sac in Embryonic Inositol Delivery?

D'Souza

Copp

Greene

et al. 2021

Advances in Nutrition

View full text Add to dashboard Cite

show abstract

“…Inositol was closely related to fetal/pediatric developmental diseases, such as neural tube defects (NTDs) [15][16][17], neonatal respiratory distress syndrome [18,19], retinopathy of prematurity [20], et al It has been reported that supplemental inositol could reduce the incidence of NTDs in folate-resistant curly tail mice [21,22]. We have observed significantly lower myo-inositol concentrations in pregnant women with NTDs, compared to normal pregnant women [23,24].…”

Section: Introductionmentioning

confidence: 69%

The Effects of Inositol Metabolism in Pregnant Women on Offspring in the North and South of China

et al. 2020

View full text Add to dashboard Cite

Background: Inositol is an essential nutrient for cell growth, survival and embryonic development. Myo-inositol is the predominant form in natural. To investigate the correlation between inositol metabolism and embryonic development, we assessed the metabolic characteristics of myo-inositol, phosphatidylinositol 4,5-bisphosphate (PI(4,5)P 2) and phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P 3) of pregnant women in the North China (Yangquan and Weihai) and South China (Nanchang and Haikou) China. Material/Methods: All data were collected by face-to-face interview during pregnant women health visits using a questionnaire. Plasma levels of myo-inositol, PI(4,5)P 2 and PI(3,4,5)P 3 from 89 randomly collected pregnant women were detected by gas chromatography-mass spectrometry and enzyme linked immunosorbent assay. Results: A total of 400 pregnant women were included in this survey. The plasma levels of myo-inositol and PI(4,5)P 2 in the North China group of pregnant women were significantly higher than that in the South China group (P<0.01). The birth weight of fetuses in the North China group was heavier than that in the South China group (P<0.01). The birth length of fetuses in Yangquan was the longest among the 4 cities (P<0.01). The incidence rate of birth defects was 3.05% in the North China group, and 0.0% in the South China group. In bivariate linear correlation analysis, the body weight correlated with myo-inositol (r=0.5044, P<0.0001), PI(4,5)P 2 (r=0.5950, P<0.0001) and PI(3,4,5)P 3 (r=0.4710, P<0.0001), the body length was correlated with PI(4,5)P 2 (r=0.3114, P=0.0035) and PI(3,4,5)P 3 (r=0.2638, P<0.0130). Conclusions: The plasma levels of myo-inositol and PI(4,5)P 2 in pregnant women had significant difference between the North and the South of China, which might be correlated with fetal development and birth defects.

show abstract

“…Further studies are needed to better characterize the target actions of INOs and its mechanisms. However, considering that several clinical trials have shown the efficacy and safety of INOs periconceptional supplementation, 28,29,56 an INOs mixture seems a promising natural compound for pregnant women with MS to improve their vascularÀmetabolic profile and, consequently, the long-term consequences to their offspring. n…”

Section: Obstetrics Original Researchmentioning

confidence: 99%

Vascular and metabolic profiles in offspring born to pregnant mice with metabolic syndrome treated with inositols

Longo

Alrais

Tamayo

et al. 2019

American Journal of Obstetrics and Gynecology

View full text Add to dashboard Cite

BACKGROUND: Inositols (INOs) supplementation during pregnancy, specifically the combination of myo-inositol (MI) and D-chiro-inositol (DCI), has been reported to improve vascular parameters in women with gestational diabetes mellitus. We demonstrated previously that offspring born to pregnant mice lacking the endothelial nitric oxide synthase (eNOSþ/e) gene have hypertension (HTN) as adults and, when fed a high-fat diet (HFD), develop a metabolic syndrome (MS) phenotype. OBJECTIVE: Our aim was to evaluate whether INOs treatment in pregnancy complicated by MS improves the vascular and metabolic profile in mice offspring programmed in utero to develop HTN and MS. MATERIALS AND METHODS: Heterozygous eNOSþ/e mice fed an HFD manifest a MS phenotype. Female eNOSþ/e mice with MS were bred with a wild-type (WT) male. On gestational day 1, pregnant females were randomly allocated to receive either a mixture of INOs (MI/ DCI: 7.2/0.18 mg/mL) or water as placebo until delivery. The female offspring obtained were genotyped and categorized as: WT (genetically normal, with eNOS gene) and eNOSþ/e offspring (genetically modified, heterozygous for eNOS gene). Both offspring developed in an abnormal uterine environment due to maternal MS. At 9e10 weeks of age, the offspring underwent a glucose tolerance test (GTT) and systolic blood pressure (SBP) measurement. The mice were then sacrificed, and the carotid arteries were isolated for evaluation of vascular responses. Responses to phenylephrine (PE), in the presence and absence of a nonspecific nitric oxide inhibitor (N-nitro-L-arginine methyl ester [L-NAME]), the vasodilator acetylcholine (ACh), and sodium nitroprusside (SNP) were assessed. RESULTS: The GTT showed lower glucose levels in both eNOSþ/eINOs (P ¼ .03) and WT-INOs (P ¼ .05) offspring born to MS dams on INOs supplementation compared to offspring born to untreated dams. SBP was higher in eNOSþ/e offspring compared to WT (169 AE 7 vs 142 AE 9 mm Hg, respectively, P ¼ .04) and INOs treatment decreased SBP in WT-INOs (110 AE 10 mm Hg, P ¼ .01) but not in eNOSþ/eINOs offspring. Maximal (%Max) contractile response to PE was higher in eNOSþ/e offspring born to MS dams and was decreased in those born to MS dams treated with INOs (%Max, eNOSþ/e, 123 AE 7 vs eNOSþ/eINOs, 82 AE 11 mm Hg, P ¼ .007). No differences were seen in PE contractile responses in WT offspring born to MS dams treated or not treated with INOs (WT, 92 AE 4 vs WT-INOs, 75 AE 7). The L-NAME response was decreased in eNOSþ/e INOs and WT-INOs offspring compared to untreated ones. The ACh vasorelaxation was impaired in eNOSþ/e and WT offspring born to MS dams, and maternal INOs treatment improved offspring vascular relaxation in both offspring (P ¼ .01 and P ¼ .03, respectively). No differences were seen in response to SNP. CONCLUSION: Inositols supplementation improved glucose tolerance, SBP, and vascular responses in adult eNOSþ/e and WT offspring born to dams with MS. Interestingly, WT born to MS dams show an altered vascular profile similar to eNOSþ/e offspring ...

show abstract

Myoinositol: The Bridge (PONTI) to Reach a Healthy Pregnancy

Cited by 14 publications

References 28 publications

Maternal Inositol Status and Neural Tube Defects: A Role for the Human Yolk Sac in Embryonic Inositol Delivery?

Maternal Inositol Status and Neural Tube Defects: A Role for the Human Yolk Sac in Embryonic Inositol Delivery?

The Effects of Inositol Metabolism in Pregnant Women on Offspring in the North and South of China

Vascular and metabolic profiles in offspring born to pregnant mice with metabolic syndrome treated with inositols

Contact Info

Product

Resources

About