The Effects of Inositol Metabolism in Pregnant Women on Offspring in the North and South of China

Abstract

Background: Inositol is an essential nutrient for cell growth, survival and embryonic development. Myo-inositol is the predominant form in natural. To investigate the correlation between inositol metabolism and embryonic development, we assessed the metabolic characteristics of myo-inositol, phosphatidylinositol 4,5-bisphosphate (PI(4,5)P 2) and phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P 3) of pregnant women in the North China (Yangquan and Weihai) and South China (Nanchang and Haikou) China. Material/Methods: All data were collected by face-to-face interview during pregnant women health visits using a questionnaire. Plasma levels of myo-inositol, PI(4,5)P 2 and PI(3,4,5)P 3 from 89 randomly collected pregnant women were detected by gas chromatography-mass spectrometry and enzyme linked immunosorbent assay. Results: A total of 400 pregnant women were included in this survey. The plasma levels of myo-inositol and PI(4,5)P 2 in the North China group of pregnant women were significantly higher than that in the South China group (P<0.01). The birth weight of fetuses in the North China group was heavier than that in the South China group (P<0.01). The birth length of fetuses in Yangquan was the longest among the 4 cities (P<0.01). The incidence rate of birth defects was 3.05% in the North China group, and 0.0% in the South China group. In bivariate linear correlation analysis, the body weight correlated with myo-inositol (r=0.5044, P<0.0001), PI(4,5)P 2 (r=0.5950, P<0.0001) and PI(3,4,5)P 3 (r=0.4710, P<0.0001), the body length was correlated with PI(4,5)P 2 (r=0.3114, P=0.0035) and PI(3,4,5)P 3 (r=0.2638, P<0.0130). Conclusions: The plasma levels of myo-inositol and PI(4,5)P 2 in pregnant women had significant difference between the North and the South of China, which might be correlated with fetal development and birth defects.

Photoperiods induced the circRNA differential expression in the thyroid gland of OVX+E2 ewes

“…In this study, the source genes of differentially expressed circRNAs found to been riched in Inositol phosphate metabolism, cGMP-PKG signaling pathway, Calcium signaling pathway, MAPK signaling pathway and Oocyte meiosis. Inositol phosphate is known to be an essential nutrient for cell growth, survival and embryonic development, and inositol metabolism is associated with embryonic development ( 43 ). Studies have shown that Cryptobacterium elegans IPMK-1 (homologous to mammalian inositol polyphosphate multi-kinase) regulates rhythmic behavior in animals, and inositol polyphosphate multi-kinase IPMK-1 regulates development by modulating calcium signaling pathway in Cryptobacterium hidradenum ( 44 ).…”

The effect of living environment on developmental disorders in cold regions

“…According to epidemiological statistics, the incidence of DDs in Northeast China is 40% higher than that in South China [14] . And the prevalence of DDs in North China is three times higher than that in South China [15] . This may be closely related to the unique geographical location, climate characteristics and residents' lifestyle in cold regions.…”