Myocardial alterations resulting from feeding partially hydrogenated marine oils and peanut oil to rats

Ackman, R. G.

doi:10.1007/bf02533832

Cited by 23 publications

(5 citation statements)

References 9 publications

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“…Previous reports have indicated the pres ence of coronary lipidosis in experimental animals fed with long-chain fatty acids [3,4], Our results show that heart lipid content did not significantly change after diets. How ever, we could not state that animals fed with long-chain fatty acids developed coro nary lipidosis, since we were sampling the entire heart and not the coronary vessels.…”

Section: Discussionsupporting

confidence: 67%

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Comparative Effects of Feeding Different Fats on Fatty Acid Composition of Major Individual Phospholipids of Rat Hearts

Ruiz-Gutiérrez

Molina²,

Vázquez³

1990

Ann Nutr Metab

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Comparative effects of feeding dietary linoleic (corn oil), oleic (olive oil), α-linolenic (soybean oil) and polyunsaturated fatty acids (fish oil) on lipid content and fatty acid composition of major individual phospholipids of rat hearts were examined. Feeding different diets did not result in lipid accumulation in the heart. Total triglyceride, nonesterified fatty acid, cholesteryl ester and phospholipid levels of heart tissue were not affected by the type of dietary fatty acid. However, heart free cholesterol levels decreased in both animals fed the olive and the fish oil diets. The percentage of individual phospholipids, phosphatidylcholine (PC), phosphatidylethanolamine (PE) and cardiolipin (CL) did not modify by changes in the dietary fat composition. Heart tissue from animals fed on olive oil were enriched with 18:1 (n-9 + n-7) fatty acid in all phospholipid fractions. Animals fed corn oil contained higher proportions of 18:2 (n-6) for PC, PE and CL, and the ingestion of the soybean oil diet increased 18:2 (n-6) for PC and CL in the same proportion as the ingestion of the corn oil diet. The levels of 22:6 (n-3) were increased in the fish oil-fed group, accompanied by both a decrease in total (n-6) fatty acids and an increase in total (n-3) fatty acids in the three phospholipid fractions. The 20:5 (n-3) was only detected in these animals. These results show that olive oil is as effective as fish oil in reducing heart cholesterol content and support earlier works suggesting the role of fish oil in preventing cardiovascular disease.

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Section: Discussionsupporting

confidence: 67%

“…Thus, both linolenic (18:3 n-3) and erucic (22:1 n-9) acids have been ac cused of causing irrepairable damage in the cardiac tissue [2]. In addition, the presence of long-chain fatty acids, typical of fish oils, has been shown to produce coronary lipido sis in experimental animals [3,4).…”

Section: Introductionmentioning

confidence: 99%

Comparative Effects of Feeding Different Fats on Fatty Acid Composition of Major Individual Phospholipids of Rat Hearts

Ruiz-Gutiérrez

Molina²,

Vázquez³

1990

Ann Nutr Metab

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“…The symptoms just mentioned were first observed in rats fed diets containing erucic acid. Corresponding findings in animals fed partially hydrogenated marine oils, which contain a broad spectrum of C22-and C20-monoenoic fatty acids including trans isomers, have been reported (5)(6)(7). In other experiments (8), however, only lipidosis and no long-term lesions could be demonstrated in hearts from rats fed partially hydrogenated marine oils.…”

Section: Introductionsupporting

confidence: 56%

Influence of partially hydrogenated vegetable and marine oils on lipid metabolism in rat liver and heart

Hølmer

Høy

Kirstein

1982

Lipids

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Partially hydrogenated marine oils containing 18:1-, 20:1- and 22:1-isomers and partially hydrogenated peanut oil containing 18:1-isomers were fed as 24-28 wt% of the diet with or without supplement of linoleic acid. Reference groups were fed peanut, soybean, or rapeseed oils with low or high erucic acid content. Dietary monoene isomers reduced the conversion of linoleic acid into arachidonic acid and the deposition of the latter in liver and heart phosphatidylcholine. This effect was more pronounced for the partially hydrogenated marine oils than for the partially hydrogenated peanut oil. The content of trans fatty acids in liver phospholipids was similar in groups fed partially hydrogenated fats. The distribution of various phospholipids in heart and liver was unaffected by the dietary fat. The decrease in deposition of arachidonic acid in rats fed partially hydrogenated marine oils was shown in vitro to be a consequence of lower delta 6-desaturase activity rather than an increase in the peroxisomal beta-oxidation of arachidonic acid. The lower amounts of arachidonic acid deposited may be a result of competition in the delta 6-desaturation not only from the C22- and C20-monoenoic fatty acids originally present in the partially hydrogenated marine oil, but also from C18- and C16-monoenes produced by peroxisomal beta-oxidation of the long-chain fatty acids.

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“…1835. et al, 1977aKramer et al, 1979aKramer et al, , 1973, peanut oil (Ackman, 1974, Cluzan et al, 1979Rocquelin and Cluzan, 1968;Vies et al, 1979), soybean oil (Hulan et al, 1977b;Kramer et al, 1979b;McCutcheon et al, 1976;Slinger, 1977), sunflower oil (Vies, 1978;Vies et al, 1976Vies et al, , 1978, safflower oil (Kramer et al, 1975;McCutcheon et al, 1976), lard (Hulan et al, 1976), and lard/corn oil mixtures (Beare-Rogers and Nera, 1977;Beare-Rogers et al, 1979, 1974. These findings indicated that factors other than, or in addition to, erucic acid were responsible for the increased incidence of cardiac lesions.…”

Section: Introductionmentioning

confidence: 65%

Pathological Changes Associated with the Feeding of Soybean Oil or Oil Extracted from Different Rapeseed Cultivars to Single Comb White Leghorn Cockerels

Corner¹,

Hulan

Nash

et al. 1985

Poultry Science

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A total of 384 Single Comb White Leghorn cockerels of the Hyline strain were fed either a basal (control) diet containing no added oil or a diet supplemented with 20% by weight of soybean oil, rapeseed oil from cultivars Tower, Candle, a mixture of Echo and Arlo high erucic acid rapeseed (HEAR), or R-500. Levels of erucic acid (22:1) in the rapeseed diets varied from .03 to 10.31%. Three birds from each unit were killed at 28, 56, 84, and 112 days and a wide range of tissues were examined histologically. A number of birds in all dietary groups had healed lesions of avian encephalomalacia. Two cockerels fed HEAR oil and 12 fed R-500 developed marked ascites, firm shrunken livers, hydropericardium, and cachectic muscular atrophy. Marked periacinar necrosis was present in birds dying with ascites. A significantly higher number of birds fed the rapeseed oils developed hepatic sinusoidal distention than birds fed the basal or soybean oil diets. Degenerative myocardial changes were seen only in R-500 and HEAR oil-fed birds. This, coupled with hepatic changes, producing shrunken firm livers, led to development of ascites, cachectic muscular atrophy, and periacinar hepatic necrosis. These changes were probably produced by the high erucic acid content of the HEAR and R-500 oils and the resultant grossly imbalanced diet.

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Myocardial alterations resulting from feeding partially hydrogenated marine oils and peanut oil to rats

Cited by 23 publications

References 9 publications

Comparative Effects of Feeding Different Fats on Fatty Acid Composition of Major Individual Phospholipids of Rat Hearts

Comparative Effects of Feeding Different Fats on Fatty Acid Composition of Major Individual Phospholipids of Rat Hearts

Influence of partially hydrogenated vegetable and marine oils on lipid metabolism in rat liver and heart

Pathological Changes Associated with the Feeding of Soybean Oil or Oil Extracted from Different Rapeseed Cultivars to Single Comb White Leghorn Cockerels

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