Mykotische Infektionen psoriatischer Nägel/Mycotic Infections of Psoriatic Nails

Abstract

Zusammenfassung: Die Verfasserin untersuchte das Vorkommen mykotischer Infektionen von Psoriasis‐Nägeln. Die Ergebnisse wurden mit den Quoten des Pilznachweises bei primärer Onychomykose verglichen. Bei Nagelpsoriasis ist die Häufigkeit von Dermatophyten‐Infektionen geringer, dagegen das Vorkommen von Sproßpilzbesiedlung höher als bei primären Onychomykosen. Summary: Mycotic infections of psoriatic nails were investigated. The cultural results were compared with the distribution of the pathogens found in primary onychomycosis. In psoriatic nails the rate of dermatophytic infections was lower and the frequency of yeast infections higher than in primary onychomycosis.

Prevalence of onychomycosis among patients with nail psoriasis who are not receiving immunosuppressive agents: Results of a pilot study

“…According to our results, Greek nail psoriasis patients are more susceptible to onychomycosis than their healthy compatriots, as the thus far recorded prevalence of onychomycosis in Greece ranges from 15.72% to 20% Two studies, also examining small samples of only nail psoriasis patients found similar results . Few studies, also examining only nail psoriasis patients found a substantially higher prevalence of onychomycosis among them; it is possible that the inclusion of patients currently being or having recently been treated with immunosuppressive agents can justify the noted difference . The majority of studies examining psoriasis patients with as well as without psoriatic nail lesions have reported a smaller prevalence of onychomycosis than the one found in our study .…”

“…36,37 Few studies, also examining only nail psoriasis patients found a substantially higher prevalence of onychomycosis among them; it is possible that the inclusion of patients currently being or having recently been treated with immunosuppressive agents can justify the noted difference. [38][39][40] The majority of studies examining psoriasis patients with as well as without psoriatic nail lesions have reported a smaller prevalence of onychomycosis than the one found in our study. 8,13,[41][42][43][44][45][46][47] This discrepancy is possibly attributed to the fact that psoriasis patients with clinically healthy nails seem to be less susceptible to dermatophyte infections of the nail than the general Case, infection proved through mycological testing; n, natural number; Percentage, refers to the total of infection cases.…”

“…Few studies also found an equal predominance of yeast and filamentous fungi over dermatophytes. 39,49 Despite its limitations, our study has clearly shown that a relationship does exist between the two diseases and that mycological testing or histopathological examination with extra PAS stain should be routinely performed on nails of psoriasis patients with lesions suggestive of onychomycosis. 7 Based on our results, the most plausible scenario explaining the high recorded frequency of onychomycosis among nail psoriasis patients seems to be the increased susceptibility of their nails to colonisation by pathogens, such as yeast and moulds, which tend to invade non-healthy nails.…”

“…Few studies also found an equal predominance of yeast and filamentous fungi over dermatophytes . Macura et al infected keratin isolated from healthy‐looking nails of psoriasis patients and healthy controls with T. mentagrophytes and C. albicans .…”

Assessment of Psoriatic Patients for Onychomycosis

“…This result agree with many studies mainly done in Iran, such data being found in their region, where this fungus was the most widespread of all non-dermatophytic fungi (4,8,17,27) . Seven studies concluded that yeast and/or non-dermatophyte moulds were more frequently found in psoriatic nails compared to the pathogens found in nails of non-psoriatic patients (18,22,24,28,29,30) . Most authors impose the conclusion that yeast is more frequently isolated from nails damaged by psoriasis.…”