Myeloperoxidase-Positive Cell Infiltration in Colorectal Carcinogenesis as Indicator of Colorectal Cancer Risk

Roncucci, Luca; Mora, Erika; Mariani, Francesco; Bursi, S.; Pezzi, Annalisa; Rossi, Giuseppina; Pedroni, Monica; Luppi, Davide; Santoro, Luisa; Monni, S; Manenti, Antonio; Bertani, A.; Merighi, A.; Benatti, Piero; Gregorio, Carmela Di; Leòn, Maurizio Ponz de

doi:10.1158/1055-9965.epi-08-0224

Cited by 89 publications

(89 citation statements)

References 38 publications

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“…Upon the invasion of bacteria, the first response is the infiltration of neutrophils and mononuclear cells in local tissue. Following the accumulation of neutrophils and mononuclear cells, the levels of myeloperoxidase (MPO) in the local tissue are increased (11). MPO is also one of the parameters in IBD modeling studies (12).…”

Section: Interleukin (Il)mentioning

confidence: 99%

Interleukin (IL)-23 Suppresses IL-10 in Inflammatory Bowel Disease

Liu

Feng

Yang

et al. 2012

Journal of Biological Chemistry

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Section: Interleukin (Il)mentioning

confidence: 99%

Interleukin (IL)-23 Suppresses IL-10 in Inflammatory Bowel Disease

Liu

Feng

Yang

et al. 2012

Journal of Biological Chemistry

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“…All patients had normal colonoscopy. Twenty-two MAs were also identified in 6 patients, and removed after operation for colorectal cancer on surgical specimens; the precise localization of the lesion was made staining the resected mucosa with a 0.1% methylene-blue solution in saline, and observing it under a dissecting microscope in order to take and process only the fields of the lesion, as previously described (16,19). All MAs, defined as dysplastic aberrant crypt foci at histology were referred to as MAs.…”

Section: Methodsmentioning

confidence: 99%

“…Colorectal cancer remains the second leading cause of cancer-related mortality in Western countries, and it develops mainly from adenomatous polyps and shows a morphological and genetic progression through an adenoma-carcinoma sequence, both in hereditary and in sporadic colorectal cancer (15 genetic and epigenetic alterations (16)(17)(18)(19). The purpose of the present study was two-fold: (i) to determine whether BCL6 is expressed during malignant transformation of the large bowel and (ii) to assess whether, and to what extent, BCL6 immunoreactivity is related to the different stages of neoplastic progression.…”

Section: Introductionmentioning

confidence: 99%

Morphological and quantitative analysis of BCL6 expression in human colorectal carcinogenesis

et al. 2013

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Abstract. The aim of the present study was to determine whether BCL6 is expressed during malignant transformation of the large bowel and to assess whether, and to what extent, immunoreactivity is related to the different stages of neoplastic progression. Samples of normal colorectal mucosa (n=22), microadenomas (n=22) and colorectal cancer (n=22), were analyzed by immunohistochemistry, immunofluorescence coupled with confocal microscopy and western blotting. Our results clearly outlined the marked increase occurring in both intensity and density of BCL6 protein expression in the normal mucosa-microadenoma-carcinoma sequence. Immunohistochemistry and immunofluorescence analyses showed that BCL6 is expressed at low levels in normal mucosa and increases in microadenoma and in cancer with statistical significance. These results were confirmed by western blotting data. The increasing expression of BCL6 in human colorectal cancer development suggests the involvement of BCL6 in tumor progression, from the earliest stages of carcinogenesis with significant increase in cancer. The enhanced understanding of the biological role of BCL6, previously shown to exert a key role in lymphomagenesis, may lead to a re-evaluation of this protein and may highlight the importance of performing further studies in order to identify novel therapeutic targets for colorectal cancer.

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“…MPO Defense response. Myeloperoxidase-positive cell infiltration in colorectal carcinogenesis is an indicator of colorectal cancer risk [35].…”

Section: Cd163mentioning

confidence: 99%

Prognostic biomarkers in oral squamous cell carcinoma: a systematic review

Rivera

Oliveira

Costa

et al. 2017

Preprint

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2Prognostic biomarkers in oral squamous cell carcinoma: a systematic review ABSTRACT Over the years, several tumor biomarkers have been suggested to foresee the prognosis of oral squamous cell carcinoma (OSCC) patients. Here, we present a systematic review to identify, evaluate and summarize the evidence for OSCC reported markers. Eligible studies were identified through a literature search of MEDLINE/PubMed until January 2016. We included primary articles reporting overall survival, disease-free survival and cause-specific survival as outcomes.Our findings were analysed using REporting recommendations for tumor MARKer prognostic studies (REMARK), QuickGo tool and SciCurve trends. We found 41 biomarkers, mostly proteins evaluated by immunohistochemistry. The selected studies are of good quality, although, any study referred to a sample size determination. Considering the lack of follow-up studies, the molecules are still potential biomarkers. Further research is required to validate these biomarkers in welldesigned clinical cohort-based studies.

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Myeloperoxidase-Positive Cell Infiltration in Colorectal Carcinogenesis as Indicator of Colorectal Cancer Risk

Cited by 89 publications

References 38 publications

Interleukin (IL)-23 Suppresses IL-10 in Inflammatory Bowel Disease

Interleukin (IL)-23 Suppresses IL-10 in Inflammatory Bowel Disease

Morphological and quantitative analysis of BCL6 expression in human colorectal carcinogenesis

Prognostic biomarkers in oral squamous cell carcinoma: a systematic review

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