Myeloperoxidase Is an Early Biomarker of Inflammation and Cardiovascular Risk in Prepubertal Obese Children

Olza, Josune; Aguilera, Concepción M.; Gil-Campos, Mercedes; Leis, Rosaura; Bueno, Gloria; Martínez-Jiménez, María Del Carmen; Valle, Miguel; Cañete, Ramón; Tojo, Rafael; Moreno, Luís A.; Gil, Ángel

doi:10.2337/dc12-0614

Cited by 80 publications

(83 citation statements)

References 26 publications

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“…Besides that, the results of our study revealed the suppressive effect of caffeine on the hepatic content of MPO, which comes into agreement with results of previous work [25]. MPO is an early biomarker of inflammation, which plays an important role in the initiation and progression of acute and chronic inflammatory diseases [26].…”

Section: Discussionsupporting

confidence: 93%

Caffeineas a Promising Antifbrotic Agent Against Ccl4-Induced Liver Fibrosis

Mostafa

Khalaf

Abo-Youssef

et al. 2017

Int J Pharm Pharm Sci

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Objective: Hepatic fibrosis is a wound-healing process in the liver with chronic injury and is characterized by an excess production and deposition of extracellular matrix (ECM) components. Our aim is to investigate the hepatoprotective effects of caffeine against CCL4-induced liver fibrosis in rats and to be compared with the reference standard N-acetylcysteine (NAC).Methods: Rats were divided into 5 groups (n=8), the 1 st group served as normal control, the 2 nd group received corn oil, the 3 rd group is a fibrosis control and the remaining two groups received in addition to CCL4, NAC (150 mg/kg/day) as a reference treatment and caffeine (15 mg/kg/day). At the end of experimental period the following parameters were measured, specific fibrosis biomarkers [hepatic transforming growth factor β1(TGF-β1) and hepatic hydroxyproline (HYP)], liver function biomarkers [serum alanine transaminase (ALT), aspartate transaminase (AST), total bilirubin and albumin], lipid profile [serum triglycerides, total cholesterol, low density lipoprotein cholesterol (LDL-Ch) and high density lipoprotein cholesterol (HDL-Ch)], inflammatory biomarkers [serum tumor necrosis factor alpha (TNF-α), hepatic myeloperoxidase (MPO)], oxidative stress biomarkers [hepatic malondialdehyde (MDA), glutathione (GSH) and catalase (CAT)], relative liver body weight and liver histopathological study. Results:Caffeine significantly improved all the aforementioned biochemical parameters and liver sections obtained from this group showed prominent histopathological improvement. Conclusion:Caffeine hepatoprotective effects may be due to modulation of the fibrous scar formation, Improvement of liver function, Antiinflammatory and antioxidant potentials.

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Section: Discussionsupporting

confidence: 93%

Caffeineas a Promising Antifbrotic Agent Against Ccl4-Induced Liver Fibrosis

Mostafa

Khalaf

Abo-Youssef

et al. 2017

Int J Pharm Pharm Sci

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“…Prepubertal obese children [129] showed an elevation of proinflammatory factors (TNF-alpha, IL-6, CPR, PAI-1), and markers of endothelial dysfunction which contribute to early increase of cardiovascular diseases later in life. Likewise, serum myeloperoxidase (MPO) level was elevated in prepubertal obese children [129].…”

Section: Metabolic Syndromementioning

confidence: 99%

“…Likewise, serum myeloperoxidase (MPO) level was elevated in prepubertal obese children [129]. MPO is an enzyme which has bactericidal action and plays an important role in the onset and progression of acute and chronic inflammatory diseases.…”

Section: Metabolic Syndromementioning

confidence: 99%

Abdominal obesity and cardiometabolic risk in children and adolescents, are we aware of their relevance?

Forkert

Rendo-Urteaga

Nascimento-Ferreira

et al. 2016

Nutrire

Self Cite

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Obesity prevalence has increased worldwide over the last decades and has reached alarming rates in low middleincome countries. Childhood has been affected by this epidemic, leading to premature dramatic health problems. Adipose tissue is currently considered as an endocrine organ modulating an inflammatory state and important metabolic processes (insulin resistance, hypertension, glucose intolerance) leading to consequences of the cardiovascular system. This situation may be worst if the excess of body fat distribution such as abdominal obesity (AO) is involved because it is associated with a more atherogenic risk profile determining the cardiometabolic risks mainly in children and adolescents. Hence, the knowledge regarding the association between AO and cardiometabolic factors aims to prevent and treat the obesity in this young population, avoiding early harmful consequences of adulthood health.

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“…MPO levels showed strong positive correlation with HbA1C, HOMA-IR, FPG ,PPG, cholesterol , LDL and also negative correlation was observed between HDL cholesterol. Chronic high concentrations of glucose and dyslipidemias cause oxidative stress and along with proinflammatory mediators may impair insulin signaling, initiates insulin resistance [20][21][22]. MPO protein abundantly expressed in polymorphonuclear neutrophils (PMNs) and monocytes, is also a catalyst of 3-nitrotyrosine (NO 2 Tyr) formation via nitrite oxidation to the potent nitrating species nitrogen dioxide (•NO 2 ) [23][24][25][26].…”

Section: Discussionmentioning

confidence: 99%