Myelolipoma of the liver

Rubin, Eva; Russinovich, N A; Luna, Licia P.; Tishler, Jack M.; Wilkerson, James A.

doi:10.1002/1097-0142(19841101)54:9<2043::aid-cncr2820540945>3.0.co;2-p

Cited by 38 publications

(7 citation statements)

References 9 publications

(1 reference statement)

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“…Fewer than 60 cases of extra-adrenal myelolipomas have been reported in the literature. Extra-adrenal myelolipomas have been described in various locations; 50% occur in the presacral region, 1 but they rarely occur in the pelvic retroperitoneum, 2 mediastinum, 3-6 kidney, 7-10 stomach, 11 greater omentum, 12 liver, 13-16 chest, 17,18 and nasal cavity. 19 Myelolipomas also rarely occur in the spleen; only 2 previous cases have been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

Giant Myelolipoma in the Spleen

Zeng

Lin

et al. 2015

Int J Surg Pathol

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Myelolipomas are benign tumors, consisting of hematopoietic cells and mature adipose tissue, which mainly occur within the adrenal gland. Extra-adrenal myelolipomas are rare, and fewer than 60 cases have been reported in the literature. Here, we report a case of intrasplenic myelolipoma in a 42-year-old man with more than 1 month of abdominal pain. Computed tomography scanning revealed a giant, heterogeneous, well-demarcated mass in the spleen. Splenectomy was performed, and an intrasplenic giant mass was completely excised. The diagnosis of myelolipoma was made based on morphological examination. To the best of our knowledge, this is the third reported case of myelolipoma in the human spleen.

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Section: Introductionmentioning

confidence: 99%

Giant Myelolipoma in the Spleen

Zeng

Lin

et al. 2015

Int J Surg Pathol

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“…On T1-weighted MR images, the mass usually appears well marginated with a capsule, shows heterogeneous hyperintensity and contains necrosis. Hepatic arteriography reveals a hypervascular mass with an avascular zone[8,11]. On T2-weighted images, the mass shows heterogeneous low-signal intensity.…”

Section: Discussionmentioning

confidence: 99%

Synchronous occurrence of a hepatic myelolipoma and two hepatocellular carcinomas

Xu¹,

Xie²,

Zhou³

et al. 2016

WJG

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Myelolipoma is a rare tumor composed of fat and bone marrow components, most of which are located in the adrenal gland. Myelolipoma in the liver is extremely rare. To date, only 10 cases have been reported in the English-language medical literature. In one of these cases, the hepatic myelolipoma was found within a hepatocellular carcinoma (HCC). In the present study, we report the first case of the synchronous occurrence of hepatic myelolipoma and HCCs in different liver sections of one patient, a 26-year-old female who was admitted to our hospital because of a 4-d history of upper abdominal pain. The unenhanced computed tomography (CT) images showed a well-defined low-density mass with adipose components in the right liver lobe, 4.2 cm × 4.1 cm in size. Two inhomogeneous low-density masses were found in the left liver lobe, 8.6 cm × 7.7 cm and 2.6 cm × 2.6 cm in size. The masses in both the right and left liver lobes were heterogeneously enhanced in the contrast-enhanced CT images. Based on the results of the imaging examination, the mass in the right liver lobe was preliminarily considered to be a hamartoma, and the two masses in the left liver were preliminarily considered to be HCCs. We performed a right hepatectomy, a left hepatic lobectomy, and a cholecystectomy. Microscopic and immunohistochemical results revealed that the tumor in the right liver lobe was a hepatic myelolipoma, and that the two tumors in the left liver lobe were HCCs.

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“…En la tomografía computarizada es característico observar una masa hipodensa con atenuaciones entre À20 y À100 HU, mientras que en la RM el mielolipoma suele manifestarse como una lesión bien definida con una seudocápsula con un contenido con elevada atenuación y tejido graso heterogéneo 7 . En la arteriografía puede comportarse como una lesión hipervascular o hipovascular según la proporción de contenido graso 3,4 .…”

Section: Discussionunclassified

“…Sin embargo, en el estudio anatomopatológico, 3 mielolipomas (23%) mostraron focos hemorrágicos intratumorales 3,4,11 . Por esto, los autores de este artículo consideran que en pacientes con elevado riesgo quirúrgico y en los que los hallazgos radiológicos e histológicos sean claramente diagnósticos de mielolipoma se puede realizar un seguimiento clínico igual que cualquier otro tumor hepático benigno.…”

Section: Discussionunclassified