Giant Myelolipoma in the Spleen

Zeng, Ying; Ma, Qiang; Lin, Li; Fu, Ping; Shen, Yan; Luo, Qiang; Zhao, Limei; Mou, Jiang-Hong; Xiao, Hualiang

doi:10.1177/1066896915617027

Cited by 11 publications

(7 citation statements)

References 21 publications

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“…As splenic myelolipomas are rare, no consensus exists as to work-up or treatment. Similar to previous case reports [ 3 – 6 ], our patient's myelolipoma was identified due to abdominal symptoms and was found on CT scan as a round, encapsulated splenic mass. While biopsy of adrenal fatty tumors is commonly employed for diagnosis, the risks of complications related to splenic biopsy are not insignificant.…”

Section: Discussionsupporting

confidence: 86%

Symptomatic Extra-Adrenal Myelolipoma in the Spleen

Nitz

Huckleby

Hwang

et al. 2020

Case Reports in Surgery

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A 42-year-old male patient presented with intermittent abdominal pain and gastrointestinal discomfort present for 4 years. Work-up included ultrasound and computed tomography, which identified a fat-containing splenic mass 5.6 cm in size. Due to recurrent symptoms, the patient sought medical care again. Subsequent images showed an increase in size to 7.6 cm, which was concerning for neoplasm. This was removed via open splenectomy, which was challenging due to intra-abdominal adhesions despite never having had any abdominal surgery. The patient’s recovery was uncomplicated. Pathologic assessment indicated that the mass was a myelolipoma. Extra-adrenal myelolipomas are rare and typically found within the retroperitoneum but are extremely rare within the spleen. This case report adds the 6th such case to the literature and demonstrates the need for it to remain in the differential diagnosis of patients with fatty splenic masses, as well as that splenectomy is an appropriate treatment.

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Section: Discussionsupporting

confidence: 86%

Symptomatic Extra-Adrenal Myelolipoma in the Spleen

Nitz

Huckleby

Hwang

et al. 2020

Case Reports in Surgery

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“…Myelolipomas can rarely appear at other sites of the human body, as well, hence the term extra-adrenal myelolipoma. Among numerous locations, myelolipomas have been described in the mediastinum [6], spleen [7], kidney [8], bones [9], thorax [10], nasal cavity [11], ectopic adrenal cortex [12,13] as well as at extradural sites [14] or in the eyes [15].…”

Section: Introductionmentioning

confidence: 99%

Adrenal myelolipoma: a comprehensive review

et al. 2017

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The average age for its diagnosis was 51 years, and no gender difference was observed. The average size of tumors was 10.2 cm. Congenital adrenal hyperplasia was associated to 10% of all cases analyzed, while other adrenal hypersecretory disorders (cortisol, aldosterone) were found in 7.5% of cases. Computed tomography and magnetic resonance imaging can be reliably used for its differential diagnosis. If the diagnosis of an adrenal myelolipoma is unambiguous, and no associated symptoms or hormonal activity are established, surgical intervention is usually not necessary.

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“…The adrenal gland is a predominant location for human myelolipoma, with a handful of reports describing extra-adrenal locations, including the thorax, pelvis and retroperitoneal space [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Splenic Myelolipomas in the Domestic Cat – to Operate or Not to Operate?

Kennedy,

Ferreira,

Dobromylskyj

et al. 2024

Preprint

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Myelolipoma is a benign, typically inert neoplasm of uncertain aetiology that is rarely reported in cats. Although commonly asymptomatic, in some cases, myelolipomas can cause abdominal discomfort or present with rupture and haemorrhage. Here, we describe a rare case of a splenic myelolipoma in a Domestic Long Hair cat in which, after extensive diagnostic investigations, clinical signs of hyporexia and weight loss were attributable to the presence of an intra-abdominal mass. The patient was treated by splenectomy and unexpectedly died during the post-operative period. Although splenectomy appears to be a sensible intervention in symptomatic patients, the optimal management of splenic myelolipomas in cats remains unknown. The risk-benefit ratio of surgical management needs to be carefully considered, and therapeutic intervention should be tailored individually to each patient.

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Giant Myelolipoma in the Spleen

Cited by 11 publications

References 21 publications

Symptomatic Extra-Adrenal Myelolipoma in the Spleen

Symptomatic Extra-Adrenal Myelolipoma in the Spleen

Adrenal myelolipoma: a comprehensive review

Splenic Myelolipomas in the Domestic Cat – to Operate or Not to Operate?

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