Mycosis Fungoides

Epstein, Ervin; LEVIN, DAVID L.; Croft, Joseph D.; LUTZNER, MARVIN A.

doi:10.1097/00005792-197201000-00004

Cited by 333 publications

(19 citation statements)

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“…Of 144 patients with mycosis fungoides reviewed by Epstein rt (d., 50% died within three and one-half years after biopsy diagnosis and within two and one-half years after development of tumors or enlarged lymph nodes. 4 In approximately 10% of the cases of mycosis fungoides the premycotic phase does not occur, and the disease initially presents with cutaneous tumors. This is the d'emblCe form of mycosis fungoide~.~,' Survival of patients with the d'emblCe form of disease is no different from patients with tumor stage following a premycotic p h a~e .~.~ Visceral involvement usually occurs shortly after the appearance of the tumor stage.…”

Section: Discussionmentioning

confidence: 99%

Laryngeal mycosis fungoides

Hood

Mark

Hunt

1979

Cancer

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Mycosis fungoides presented as a tumor of the arytenoid cartilage and epiglottis of the larynx of an 80-year-old female. The tumor was initially interpreted as an undifferentiated small cell malignant neoplasm and treated with radiation. Two years later the patient developed widespread cutaneous involvement with mycosis fungoides, including mycosis fungoides bullosum. The mycosis fungoides progressed to death over the next two years. At autopsy widespread visceral involvement was present. The larynx was extensively infiltrated with mycosis fungoides, and the histology was similar to the original laryngeal biopsy. Although mycosis fungoides is generally thought of as a cutaneous disease, it may rarely present in a squamous epithelium-lined organ other than the skin.

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Section: Discussionmentioning

confidence: 99%

Laryngeal mycosis fungoides

Hood

Mark

Hunt

1979

Cancer

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“…commun., 1995[]. The aetiology of MF remains unknown, and no specific therapy used to date has significantly altered patient survival [5,6,7,8,9,10]. There is limited clinical information about the effect of different treatment strategies [11,12,13], probably due to the relatively low incidence and relatively long survival rate.…”

Section: Introductionmentioning

confidence: 99%

Survival of Mycosis Fungoides in Patients in the Southeast of England

Morales

Putcha²,

Evans³

et al. 2005

Dermatology

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Background: Mycosis fungoides (MF) is the most common skin lymphoma. The aetiology of MF remains unknown, and no therapy has to date significantly altered patient survival. Objective: The present study examines trends in survival of MF patients in a well-defined population-based disease group, namely patients registered over a 40-year period at the Thames Cancer Registry, Southeast England. Methods: The Thames Cancer Registry is a population-based registry, covering a population of approximately 14 million people. Data were taken from the Surveillance, Epidemiology and End Results cancer registry programme and the National Centre for Health Statistics. The database was used to identify cases of MF diagnosed between 1961 and 2000. A total of 985 records were identified, 821 (83%) of which had complete information on age, sex, year of diagnosis and area of residence. The observed and relative survivals of patients diagnosed during the periods 1971–1975, 1981–1985 and 1991–1995 were examined over a 5-year period of follow-up, using the relsurv Stata program to perform Cox proportional hazard analysis. Results: A total of 821 MF eligible patients were available with a median follow-up of 4.3 years and a maximum follow-up of 30 years. The overall 5-year relative survival rate was 80%, and there was marked improvement between 1971 and 1981. The prognostic factors leading to a significantly poorer survival were high age, male sex, the presence of the Sézary syndrome, the use of hormone treatment and radiotherapy. Conclusions: A statistically significantly better survival over the last 20 years was found. The prognosis is generally good for most patients but not all. The best survival was seen for the female patients under 45 years of age without the presence of the Sézary syndrome. This difference in survival may be partly due to a difference in the disease stage or different treatment, or to both.

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“…Le «National Institute of Health», Bethesda, Md., a, par exemple, récemment publié [6] le résultat de l'étude de 144 patients traités entre 1954 et 1969 par diverses thérapeutiques: les irradiations donnent le pourcentage le plus élevé (88%) de réponses favorables au traitement, suivies d'assez près par les applications locales d'ypérite azotée (75%).…”

Section: Résultats Des Traitements Radiologiques Palliatifsunclassified

“…The palliative and the curative aspects of radiotherapy in mycosis fungoides are analyzed.Selon l'opinion presque unanime des chercheurs [2,5,6,16,17], il n'existe aucun traitement curatif du mycosis fongoïde. C'est donc l'intérêt de la radiothérapie en tant que thérapeutique palliative qu'il convient d'examiner d'abord.…”

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