Mycoplasma pneumoniae infection and asthma in children

Kumar, Surinder; Roy, Ruma; Sethi, Gulshan Rai; Saigal, S

doi:10.1177/0049475518816591

Cited by 40 publications

(30 citation statements)

References 3 publications

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“…The low rate of u-B and negative case of u-A in the current study are consistent with the results that showed u viruses caused respiratory diseases in young and middle-aged individuals more than children (43). Some studies have shown that the spread of u with S.pneu causes pneumonia, bronchitis, sinus infections and ear infections (44,45). However, in the present study, although S.pneu was frequent in asthmatic children and was associated with the exacerbation of the asthma attacks, there were no u infections in our study population.…”

Section: Discussionsupporting

confidence: 92%

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Common Microbial Agents in Asthmatic Children With Respiratory Infection and Productive Cough

Sabet

Mirhosseini

Basharkhah

et al. 2020

Preprint

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BackgroundMicrobes can influence on the development and somehow on triggering of asthma attacks. Therefore, in this study the more significant microbial infections which trigger the attacks in children were evaluated.MethodsA total of 41 nasopharyngeal and oro-pharyengeal swabs were obtained from the Pediatric Allergy Clinic of two educational hospitals, and sent to a Molecular Laboratory for evaluation of 21 bacterial and viral respiratory pathogens using qPCR-TaqMan method.ResultsThe main bacterial infections were S.aur 18/41 (43.9%), S.pneu 16/41 (39%), C.pneu 12 /41 (29.3%), and HIB 17/41 (41.5%) while the most viral infections were and HRSV 3/41 (7.3%) and FluB, HRV, HMPVA.B, HPIV-2,3,4, HcoV-63 and HcoV-229 in 2 cases (4,9%), in asthmatic children. Although, bacterial infections were more common in both gender, the frequency of those agents were statistically difference between girls and boys population (P=0.02). There were positive correlations between S. pneu infection with asthma attack and bronchitis (P= 0.02 and P= 0.001, respectively). Furthermore, a positive correlation was found between AV and RSVA.B infections with allergic rhinitis (P= 0.02 and P= 0.001, respectively).ConclusionIn conclusion, it is more likely that in this region with a population of 6.2 million and more than 25 million tourists, the bacterial respiratory infections, particularly, HIB, S.aur and S. pneu were more common, however, and consistence with other studies HRSV and Flu.B have been dominant viral infections in asthmatic attacks.

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Section: Discussionsupporting

confidence: 92%

“…This opportunistic bacterium was detected in 41.5% of the studied children with asthmatic exacerbations, which in consistent with some other studies on adulthood (48). Although H1B, S.aur, S.pneu and C.pneu are more detected in infant and school-aged children, other infection agents are less common in adolescence (45).…”

Section: Discussionsupporting

confidence: 91%

Common Microbial Agents in Asthmatic Children With Respiratory Infection and Productive Cough

Sabet

Mirhosseini

Basharkhah

et al. 2020

Preprint

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“…Mycoplasma spp. are also found in children with asthma . Chlamydophila spp., another atypical bacteria associated with asthma exacerbation in humans, were detected by immunohistochemistry more frequently in the bronchial epithelial cells of asthmatic horses .…”

Section: Discussionmentioning

confidence: 88%

Tracheal microbial populations in horses with moderate asthma

Manguin

Pepin

Boivin

et al. 2020

Veterinary Internal Medicne

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Background There are limited data on potential dysbiosis of the airway microbiota in horses with asthma. Hypothesis/Objectives We hypothesized that the respiratory microbiota of horses with moderate asthma is altered. Our objectives were (a) to quantify tracheal bacterial populations using culture and qPCR, (2) to compare aerobic culture and qPCR, and (c) to correlate bacterial populations with bronchoalveolar lavage fluid (BALF) cytology. Animals Eighteen horses with moderate asthma from a hospital population and 10 controls. Methods Prospective case‐control study. Aerobic culture was performed on tracheal aspirates, and streptococci, Pasteurella multocida, Chlamydophila spp., Mycoplasma spp., as well as 16S (bacterial) and 18S (fungal) rRNA subunits were quantified by qPCR. Results Potential pathogens such as Streptococcus spp., Actinobacillus spp., and Pasteurellaceae were isolated from 8, 5, and 6 horses with asthma and 3, 0, and 2 controls, respectively. There was a positive correlation between Streptococcus spp. DNA and 16S rRNA gene (r ≥ 0.7, P ≤ 0.02 in both groups), but the overall bacterial load (16S) was lower in asthma (1.5 ± 1.3 versus 2.5 ± 0.8 × 104 copy/μL, P < 0.05). There was no association between microbial populations and clinical signs, tracheal mucus or BALF inflammation. Conclusions and Clinical Importance This study does not support that bacterial overgrowth is a common feature of chronic moderate asthma in horses. Lower bacterial load could suggest dysbiosis of the lower airways, either as a consequence of chronic inflammation or previous treatments, or as a perpetuating factor of inflammation.

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“…Wiele badań i metaanaliz jasno wskazuje na ścisłe powiązanie pomiędzy infekcjami dróg oddechowych (wirusowymi i bakteryjnymi) a astmą. Zwłaszcza infekcje rinowirusowe, mykoplazmatyczne mogą powodować zaostrzenia astmy u dzieci [15,16]. Jednocześnie -rozpoznana astma wczesnodziecięca, która nie jest niedostatecznie kontrolowana, sprzyja zakażeniom.…”

Section: Częste Zaostrzenia I Infekcje Dróg Oddechowychunclassified

Konsekwencje nieleczonej lub źle leczonej astmy u dzieci

Sybilski

2021

Alergoprofil

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Astma jest najczęstszą przewlekłą chorobą dolnych dróg oddechowych u dzieci. Zwykle rozpoczyna się we wczesnym dzieciństwie, ma niestabilny i nieprzewidywalny przebieg. Zarówno przyczyny, jak i prawdopodobne mechanizmy patologiczne przeplatają się wzajemnie. U podłoża astmy leży proces zapalny w drogach oddechowych, w którego wyniku występują skurcz mięśniówki oskrzeli, pogrubienie ściany dróg oddechowych oraz wzmożone wydzielanie śluzu. Do czynników wpływających na złą kontrolę astmy, częste zaostrzenia zaliczamy: błędne rozpoznanie, nieprzestrzeganie zaleceń lekarskich, złą technikę podawania leków, niedostosowanie sprzętu do wieku dziecka, złą dawkę leku wziewnego, narażenie na czynniki drażniące i nasilające chorobę oraz brak leczenia współistniejącego nieżytu nosa. Konsekwencjami nieleczonej lub źle leczonej astmy u dzieci są: remodeling, upośledzenie rozwoju płuc, zwiększone ryzyko chorób płuc u dorosłych, częste zaostrzenia i infekcje dróg oddechowych, zahamowanie tempa wzrastania, otyłość, ograniczenie wydolności oddechowej i aktywności fizycznej, zaburzenia snu, obniżona jakość życia, absencja w szkole i gorsze wyniki w nauce oraz problemy psychiczne. Aby uniknąć niekorzystnych konsekwencji astmy u dzieci, należy wcześnie rozpoznać chorobę i prawidłowo ją leczyć, stosować odpowiednie, bezpieczne leki i techniki podawania, kontrolować i weryfikować postępowanie terapeutyczne, unikać czynników drażniących i nasilających objawy, edukować opiekunów i pacjentów, zachęcać do aktywności fizycznej, uprawiania sportów oraz redukcji masy ciała dzieci otyłych.

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Mycoplasma pneumoniae infection and asthma in children

Cited by 40 publications

References 3 publications

Common Microbial Agents in Asthmatic Children With Respiratory Infection and Productive Cough

Common Microbial Agents in Asthmatic Children With Respiratory Infection and Productive Cough

Tracheal microbial populations in horses with moderate asthma

Konsekwencje nieleczonej lub źle leczonej astmy u dzieci

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