Mutagenicity of Tap and River Water in Niigata Prefecture.

Tanaka, Kazuhiro; Morita, Yasuhiko; Takahashi, Yukio

doi:10.2965/jswe.16.657

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…Our findings appear to be in agreement with those reported by several researchers (Sayoto et al 1990;Otsu et al 1998). In other studies, however, compounds adsorbed with XAD-2 from the Shinano River water (Tanaka et al 1993) or with CSP-800 or PS-2 resin from the Shinano River water when chlorinated (Komatsu et al 2004) showed positive mutagenicity in the test of TA100. This discrep- ancy may have been caused by the difference of the water samples used in the studies in addition to the difference of adsorbent material.…”

Section: Discussionsupporting

confidence: 94%

“…However, mutagenicity and carcinogenicity derived from trace compounds in river water have received a lot of attention in terms of their possible effects on human health (Kinae et al 1992). There have also been studies on the mutagenicity of tap water (Shibuya et al 1993) and of river water and tap water (Sayoto et al 1993;Tanaka et al 1993;Komatsu et al 2004) using the Ames test (Maron and Ames 1983). In other studies, relationships between the mutagenicity of water, bottom sediment, or particulate matter and the concentration of poly-aromatic hydrocarbons (PAHs) have been reported.…”

Section: Mutagenicity Assaymentioning

confidence: 99%

See 1 more Smart Citation

Contamination of the Shinano River Water with Mutagenic Substances after the Niigata Chuetsu Earthquake

Fujimoto

Tsuchiya

Shibuya

et al. 2007

Tohoku J. Exp. Med.

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While normally monitoring the Shinano River water quality, including examinations for mutagenicity, the Niigata Chuetsu Earthquake suddenly occurred on October 23, 2004. However, the influence of this earthquake on the mutagenicity of river water has not yet been well studied. To clarify the regional and seasonal changes in mutagenicity of the Shinano River water, blue rayon was suspended for 24 hrs at 4 sampling sites, once a month from September 2004 through August 2005. Mutagenicity was evaluated by the Ames test using Salmonella typhimurium TA98 (TA98) and TA100 with or without metabolic activation by S9 mixture. To detect and identify poly-aromatic hydrocarbons that may be responsible for the mutagenicity of the river water, we analyzed benzo[a]pyrene, benzophenone, 4-nitrotoluene, or other compounds using gas chromatography-mass spectrometry and total ion chromatogram spectra. Positive manifestations of TA98 with S9 mixture were observed at the 4 sampling sites throughout the 12-month test, showing a tendency to be higher at the downstream site and in winter. However, the highest mutagenicity was observed in the sample collected at the most upstream sampling site in December 2004, and fluoranthene or pyrene consisting mainly in coal tar was detected only in the samples collected in December 2004. Although benzo[a]pyrene, benzophenone, and 4-nitrotoluene were below the detection limits, non-mutagens such as aliphatic hydrocarbons or esters were frequently detected. Our findings indicate that either fluoranthene or pyrene was mainly responsible for the mutagenicity of the river water in December 2004, suggesting the possibility of oil contamination caused by the Niigata Chuetsu Earthquake.the Shinano River water; mutagenicity; the Ames test; gas chromatography-mass spectrometry; total ion chromatogram spectra

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Section: Discussionsupporting

confidence: 94%