Mutagenic activity in waste from an aluminum products factory in Salmonella/microsome assay

Varella, Soraya Duarte; Pozetti, Gilberto Luiz; Vilegas, Wagner; Varanda, Eliana A.

doi:10.1016/j.tiv.2004.05.003

Cited by 26 publications

(15 citation statements)

References 21 publications

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“…MI is the average number of revertants per plate divided by the average number of revertants per plate from the negative (solvent) control. A sample was considered positive when the MI ≥ 2 for at least one of the tested doses and if it gave a reproducible dose-response curve (Varella et al, 2004;Santos et al, 2008). Extracts that presented concentrations that induces significant difference in comparison to negative control revertants frequency and MI higher than 1.5 and lower than 2 were considered as a weak mutagen (Mortelmans & Zeiger, 2001).…”

Section: Ames Mutagenicity Assaymentioning

confidence: 99%

Mutagenicity of two species of the genus Alchornea measured by Salmonella microsome assay and micronucleus test

Santos¹,

Calvo²,

Cólus³

et al. 2010

Rev. bras. farmacogn.

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Some species of the plant genus Alchornea (family Euphorbiaceae) are widely used in popular medicine, mainly in South America and in Africa. Several kinds of biological activity have been seen in the species: antioxidant, antifungal, anti-inflammatory, antibacterial, cytotoxic against tumor cell lines and inhibitory to the replication of HIV-1 and HIV-2. In Brazil, the species Alchornea castaneaefolia Willd. A. Juss. and Alchornea glandulosa Poepp. & Endl. are used by the local population to treat rheumatism, arthritis and muscular pains. In view of the popular use of these plants as medicines and the potential risks from their consumption, we assessed the mutagenic potential of chloroform and methanol extracts of the leaves of these plant species, employing the in vivo micronucleus test and the Ames assay. The data obtained showed that the chloroform extracts were not mutagenic. The methanol extract of A. castaneaefolia was mutagenic to strain TA98 of Salmonella typhimurium and the methanol extract of A. glandulosa to strains TA98 and TA97a. The methanol extracts of both species of Alchornea were mutagenic in vivo at the largest dose employed. The probable mutagenic agents involved were the aglycone quercetin and amentoflavone, present in both species.

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Section: Ames Mutagenicity Assaymentioning

confidence: 99%

Mutagenicity of two species of the genus Alchornea measured by Salmonella microsome assay and micronucleus test

Santos¹,

Calvo²,

Cólus³

et al. 2010

Rev. bras. farmacogn.

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“…A sample was considered positive when the mutagenic index was Ն2 for at least one of the tested doses and when the response was dose-dependent. 14 …”

Section: Ames Mutagenicity Assaymentioning

confidence: 99%

Modulatory Effect of Byrsonima basiloba Extracts on the Mutagenicity of Certain Direct and Indirect-Acting Mutagens in Salmonella typhimurium Assays

Lira

Santos

Sannomiya

et al. 2008

Journal of Medicinal Food

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Byrsonima basiloba A. Juss. species is a native arboreal type from the Brazilian "cerrado" (tropical American savanna), and the local population uses it to treat diseases, such as diarrhea and gastric ulcer. It belongs to the Malpighiaceae family, and it is commonly known as "murici." Considering the popular use of B. basiloba derivatives and the lack of pharmacological potential studies regarding this vegetal species, the mutagenic and antimutagenic effect of methanol (MeOH) and chloroform extracts were evaluated by the Ames test, using strains TA97a, TA98, TA100, and TA102 of Salmonella typhimurium. No mutagenic activity was observed in any of the extracts. To evaluate the antimutagenic potential, direct and indirect mutagenic agents were used: 4 nitro-o-phenylenediamine, sodium azide, mitomycin C, aflatoxin B 1 , benzo[a]pyrene, and hydrogen peroxide. Both the extracts evaluated showed antimutagenic activity, but the highest value of inhibition level (89%) was obtained with the MeOH extract and strain TA100 in the presence of aflatoxin B 1 . Phytochemical analysis of the extracts revealed the presence of n-alkanes, lupeol, ursolic and oleanolic acid, (ϩ)-catechin, quercetin-3-O-␣-L-arabinopyranoside, gallic acid, methyl gallate, amentoflavone, quercetin, quercetin-3-O-(2Љ-O-galloyl)-␤-D-galactopyranoside, and quercetin-3-O-(2Љ-O-galloyl)-␣-L-arabinopyranoside.

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“…For the mutagenicity assays, the mutagenic index was calculated for each concentration, which is the average number of revertants per plate divided by the average number of revertants per plate with the negative (solvent) control. A sample was considered mutagenic when were observed a dose-response relationship and a two-fold increase in the number of mutants with at least one concentration was observed [25][26][27][28].…”

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confidence: 99%

Mutagenic and antimutagenic properties of some lichen species grown in the Eastern Anatolia Region of Turkey

et al. 2012

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Mutagenic activity in waste from an aluminum products factory in Salmonella/microsome assay

Cited by 26 publications

References 21 publications

Mutagenicity of two species of the genus Alchornea measured by Salmonella microsome assay and micronucleus test

Mutagenicity of two species of the genus Alchornea measured by Salmonella microsome assay and micronucleus test

Modulatory Effect of Byrsonima basiloba Extracts on the Mutagenicity of Certain Direct and Indirect-Acting Mutagens in Salmonella typhimurium Assays

Mutagenic and antimutagenic properties of some lichen species grown in the Eastern Anatolia Region of Turkey

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