Mussel-Inspired Thermoresponsive Polypeptide–Pluronic Copolymers for Versatile Surgical Adhesives and Hemostasis

Lu, Dedai; Wang, Hongsen; Li, Tingʹe; Li, Yunfei; Dou, Fajuan; Sun, Shuhan; Guo, Hongyun; Liao, Shiqi; Yang, Zhiwang; Wei, Qiangbing; Lei, Ziqiang

doi:10.1021/acsami.6b16575

Cited by 66 publications

(54 citation statements)

References 72 publications

(118 reference statements)

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“…[ 2 ] For example, hydrogels with tissue‐reactive functional groups, such as the catechol and aldehyde groups have demonstrated high tissue adhesiveness. [ 16,17 ] In addition, the hydrogels that are crosslinked by dynamic bonds exhibit self‐healing capacities and hydrogels formed by double crosslinking often have higher mechanical strength. [ 18,19 ] Recently, various functional hydrogels have been applied to promote wound healing.…”

Section: Introductionmentioning

confidence: 99%

“…[ 21,23 ] Additionally, the catechol and aldehyde groups used in the formation of these two bonds have been reported to improve the tissue adhesion capacity via multiple non‐covalent and covalent interactions. [ 16,17 ] Rationally introducing these two bonds into a polymer network was inspired by the curing and adhesion process that occurs in mussel glue (Scheme 1b). Marine mussels secrete a stored low pH (<5) catechol‐containing adhesive solution with Fe 3+ and this pH enables the weak mono‐complex between catechol and Fe 3+ .…”

Section: Introductionmentioning

confidence: 99%

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Bioinspired Double‐Dynamic‐Bond Crosslinked Bioadhesive Enables Post‐Wound Closure Care

Chen

et al. 2020

Adv Funct Materials

124

122

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Most existing bioadhesives, even those showing superiority in wound closure effectiveness, do not assist in the post-wound closure process. A bioinspired, in situ formed, double-dynamic-bond crosslinked hydrogel bioadhesive that is capable of efficiently closing open wounds and enabling post-wound closure care is reported. Catechol-modified ε-poly-l-lysine and oxidized dextran are employed as natural polymer backbones and they are in situ crosslinked using Schiff 's base dynamic bond and catecholFe coordinate dynamic bond through a process inspired by that used to cure marine mussel glue, forming a hydrogel bioadhesive. The unique double-dynamic-bond crosslinked structure endows the bioadhesive with higher mechanical and adhesive strength while retaining quick dissociation and good self-healing capacities. Accordingly, the bioadhesive can exhibit multiple desirable functions, such as dissolution on demand, repeatable adhesiveness, adhesive and mechanical strength sufficient for wound closure, injectability, and good biocompatibility (DREAMING). After efficiently closing skin incisions, the bioadhesive can be facilely removed or repeatedly close the reopened wounds, thus enabling post-wound closure care. On the basis of favorable functions in wound closure and the ability to enable post-wound closure care, the bioadhesive demonstrates great potential in dealing with skin wounds.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bioinspired Double‐Dynamic‐Bond Crosslinked Bioadhesive Enables Post‐Wound Closure Care

Chen

et al. 2020

Adv Funct Materials

124

122

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“…ROP is another most common method used for the fabrication of redox‐responsive nanogels. The synthesis of well‐defined polypeptide architectures via ROP of N ‐carboxyanhydride (NCA) has received increasing attention during the last decade . Several reports have been published depicting the synthesis of micelles, vesicles, and nanogels by controlled ROP of NCAs .…”

Section: Fabrication Of Redox‐responsive Nanogelsmentioning

confidence: 99%

A Comprehensive Outlook of Synthetic Strategies and Applications of Redox‐Responsive Nanogels in Drug Delivery

Kumar

Liu

Behl

2019

Macromolecular Bioscience

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Increasing recognition of the role of oxidative stress in the pathogenesis of many clinical conditions and the existence of defined redox potential in healthy tissues has led to extensive research in the development of redox‐responsive materials for biomedical applications. Especially, considerable growth has been seen in the fabrication of polymeric nanogel–based drug delivery carriers utilizing redox‐responsive cross‐linkers bearing a variety of functional groups via various synthetic strategies. Redox‐responsive polymeric nanogels provide an advantage of facile chemical modification post synthesis and exhibit a remarkable response to biological redox stimuli. Due to the interdisciplinary nature of the subject, a more profound combined conceptual knowledge from a chemical and biological point of view is imperative for the rational design of redox‐responsive nanogels. The present review provides an insight into the design and fabrication of redox‐responsive nanogels with particular emphasis on synthetic strategies utilized for the development of redox‐responsive cross‐linkers, polymerization techniques being followed for nanogel development and biomedical applications. Cooperative effect of redox trigger with other stimuli such as pH and temperature in the evolution of dual and triple stimuli‐responsive nanogels is also discussed.

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“…Fibrin sealant, also referred to as "fibrin glue," is a surgical hemostatic agent derived from plasma coagulation proteins (Jackson, 2001). It has been extensively used in clinical surgeries since the Food and Drug Administration (FDA) approved fibrin sealant in 1998 for hemostasis and tissue sealant (Busuttil, 2003;Lu, Wang, Li, Li, Dou, et al, 2017b;Radosevich, Goubran, & Burnouf, 1997). However, fibrin glue is expensive, exhibits relatively weak tensile and adhesion strengths, and requires the support of sutures or staples (Ono et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

In situ forming gelatin/hyaluronic acid hydrogel for tissue sealing and hemostasis

Luo

Liu

et al. 2019

J Biomed Mater Res

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Fibrin glue has been widely used as a surgical sealing and hemostatic agent. Its application is restricted due to poor tissue adhesion and low mechanical strength. To develop better tissue sealant and hemostatic agent, this study prepared the injectable hydrogels by chemically cross‐linking gelatin (G) with or without hyaluronic acid (HA) in situ at a mild condition. The rheological analysis, Fourier transform infrared spectroscopy, swelling, proteolytic degradation, biocompatibility, tissue sealing, and hemostatic ability of the hydrogels were investigated. It was found that the chemical cross‐linking rapidly formed in both self‐crosslinking gelatin (sc‐G) and gelatin/hyaluronate acid (G/HA) hydrogels. The hydrogels could be degraded by trypsin and had a desirable biocompatibility. The tissue sealing ability of the hydrogels was superior to fibrin glue. Furthermore, the G/HA hydrogel had similar hemostatic performance as fibrin glue, and was better than that of gelatin hydrogel. The results in the study indicated that the G/HA hydrogel could be used in clinic as a tissue sealant or surgical hemostat.

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Mussel-Inspired Thermoresponsive Polypeptide–Pluronic Copolymers for Versatile Surgical Adhesives and Hemostasis

Cited by 66 publications

References 72 publications

Bioinspired Double‐Dynamic‐Bond Crosslinked Bioadhesive Enables Post‐Wound Closure Care

Bioinspired Double‐Dynamic‐Bond Crosslinked Bioadhesive Enables Post‐Wound Closure Care

A Comprehensive Outlook of Synthetic Strategies and Applications of Redox‐Responsive Nanogels in Drug Delivery

In situ forming gelatin/hyaluronic acid hydrogel for tissue sealing and hemostasis

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