Bioinspired Double‐Dynamic‐Bond Crosslinked Bioadhesive Enables Post‐Wound Closure Care

Li, Sidi; Chen, Ning; Li, Xueping; Li, Yang; Xie, Zhipeng; Ma, Zongle; Zhao, Jin; Hou, Xin; Yuan, Xubo

doi:10.1002/adfm.202000130

Cited by 123 publications

(114 citation statements)

References 38 publications

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“…Millions of wounds caused by accidental trauma or surgical operations require treatment every year [ 1 , 2 ]. Open wounds are susceptible to external bacterial infections, leading to a risk of severe wound inflammation, inhibiting wound healing, and even leading to the risk of death [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Polydopamine nanoparticle-dotted food gum hydrogel with excellent antibacterial activity and rapid shape adaptability for accelerated bacteria-infected wound healing

Zeng

Qian

Huang

et al. 2021

Bioactive Materials

151

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Most commonly used wound dressings have severe problems, such as an inability to adapt to wound shape or a lack of antibacterial capacity, affecting their ability to meet the requirements of clinical applications. Here, a nanocomposite hydrogel (XKP) is developed by introducing polydopamine nanoparticles (PDA NPs) into a food gum matrix (XK, consisting of xanthan gum and konjac glucomannan, both FDA-approved food thickening agents) for skin wound healing. In this system, the embedded PDA NPs not only interact with the food gum matrix to form a hydrogel with excellent mechanical strength, but also act as photothermal transduction agents to convert near-infrared laser radiation to heat, thereby triggering bacterial death. Moreover, the XKP hydrogel has high elasticity and tunable water content, enabling it to adapt to the shape of the wound and insulate it, providing a moist environment suitable for healing. In-vivo skin wound healing results clearly demonstrate that XKP can significantly accelerate the healing of wounds by reducing the inflammatory response and promoting vascular reconstruction. In summary, this strategy provides a simple and practical method to overcome the drawbacks of traditional wound dressings, and provides further options when choosing suitable wound healing materials for clinical applications.

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Section: Introductionmentioning

confidence: 99%

Polydopamine nanoparticle-dotted food gum hydrogel with excellent antibacterial activity and rapid shape adaptability for accelerated bacteria-infected wound healing

Zeng

Qian

Huang

et al. 2021

Bioactive Materials

151

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“…In contrast, the Schiff's base reaction and acylhydrazone bond, as other representative reversible reactions, exhibit a broader application prospect in self‐healing CHs. The Schiff's base reactions form dynamic chemical bonds between aldehyde and amine, while the acylhydrazone bonds usually form between aldehyde and hydrazide, [ 129–133 ] as illustrated in Figure 4c,d. A self‐healing biocompatible polysaccharide‐based hydrogel constructed by the Schiff's base reaction of N‐carboxyethyl chitosan and adipic acid dihydrazide in the presence of oxidized sodium alginate (OSA) showed a high self‐healing efficiency of 95% due to the coexistence of dynamic imine and acylhydrazone bonds.…”

Section: Stretching and Self‐healing Strategiesmentioning

confidence: 99%

Conductive Hydrogel‐Based Electrodes and Electrolytes for Stretchable and Self‐Healable Supercapacitors

Cheng

Zhang

Wang

et al. 2021

Adv Funct Materials

194

110

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Stretchable self‐healing supercapacitors (SCs) can operate under extreme deformation and restore their initial properties after damage with considerably improved durability and reliability, expanding their opportunities in numerous applications, including smart wearable electronics, bioinspired devices, human–machine interactions, etc. It is challenging, however, to achieve mechanical stretchability and self‐healability in energy storage technologies, wherein the key issue lies in the exploitation of ideal electrode and electrolyte materials with exceptional mechanical stretchability and self‐healing ability besides conductivity. Conductive hydrogels (CHs) possess unique hierarchical porous structure, high electrical/ionic conductivity, broadly tunable physical and chemical properties through molecular design and structure regulation, holding tremendous promise for stretchable self‐healing SCs. Hence, this review is innovatively constructed with a focus on stretchable and self‐healing CH based electrodes and electrolytes for SCs. First, the common synthetic approaches of CHs are introduced; then the stretching and self‐healing strategies involved in CHs are systematically elaborated; followed by an explanation of the conductive mechanism of CHs; then focusing on CH‐based electrodes and electrolytes for stretchable self‐healing SCs; subsequently, application of stretchable and self‐healing SCs in wearable electronics are discussed; finally, a conclusion is drawn along with views on the challenges and future research directions regarding the field of CHs for SCs.

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“…There are other multi-crosslinked hydrogels that you can refer to. [188,[300][301][302][303][304][305][306][307][308] The structural diversity of hydrogels Hydrogels can be formed into almost any size and shape. In hydrogels, there are features with lengths spanning from centimeters to sub-nanometers.…”

Section: Multi-crosslinkingmentioning

confidence: 99%

Hydrogel: Diversity of Structures and Applications in Food Science

Jia

Luo

2021

Food Reviews International

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Hydrogels are a series of soft and wet materials with three dimensions of crosslinked networks. Hydrogels have attracted great attention due to their diverse functional properties, and their wide range of applications, such as in soft robots and actuators, stretched electronic devices, tissue engineering materials, controlled-release drug delivery vehicles, biomedicine materials, food science, and (bio)sensors. In general, there are four core concerns in hydrogel science, including the polymer source, structure fabrication, gel function, and gel applications. According to the logic that the "structure determines function", it is believed that rational design of structures can effectively regulate the functions and applications of hydrogels. Hence, in the current review, "structure" as the core topic will be highly regarded, and the crosslinking mechanisms and structural diversity of hydrogels are comprehensively summarized. Additionally, hydrogels also show their great application potential in food science. Hence, the current review also pays more attention to the application of hydrogels in food nutrition and health, food engineering and processing, and food safety. It is whished that this review not only serves as a reference for improving the comprehensive understanding of the structural design of hydrogels but also provides a forward-looking idea for hydrogel applications in food science.

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Bioinspired Double‐Dynamic‐Bond Crosslinked Bioadhesive Enables Post‐Wound Closure Care

Cited by 123 publications

References 38 publications

Polydopamine nanoparticle-dotted food gum hydrogel with excellent antibacterial activity and rapid shape adaptability for accelerated bacteria-infected wound healing

Polydopamine nanoparticle-dotted food gum hydrogel with excellent antibacterial activity and rapid shape adaptability for accelerated bacteria-infected wound healing

Conductive Hydrogel‐Based Electrodes and Electrolytes for Stretchable and Self‐Healable Supercapacitors

Hydrogel: Diversity of Structures and Applications in Food Science

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