Muscle weakness in septic patients requiring mechanical ventilation: Protective effect of transcutaneous neuromuscular electrical stimulation

Rodríguez, Pablo; Setten, Mariano; Maskin, Luis Patricio; Bonelli, Ignacio; Vidomlansky, S. Romero; Attie, Shiry; Frosiani, Silvana L.; Kozima, Shigeru; Valentini, Ricardo

doi:10.1016/j.jcrc.2011.04.010

Cited by 140 publications

(233 citation statements)

References 27 publications

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“…The most prevalent ICU admission diagnosis in our study was sepsis (60%). Studies conducted in ICUs involving the use of NMES have demonstrated that the most common diagnoses on admission are sepsis, COPD, and trauma (28,30,35). Sepsis is known to generate a reaction of protein hypercatabolism in the muscles, contributing to loss of muscle mass.…”

Section: Discussionmentioning

confidence: 99%

Use of neuromuscular electrical stimulation to preserve the thickness of abdominal and chest muscles of critically ill patients: A randomized clinical trial

Acqua¹,

Sachetti²,

Santos³

et al. 2017

J Rehabil Med

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Objective: To evaluate and compare the effects of neuromuscular electrical stimulation combined with conventional physical therapy on muscle thickness in critically ill patients. Design: Double-blind, randomized controlled trial. Patients: Twenty-five patients participated in the study. Methods: Patients on mechanical ventilation for 24-48 h were randomized to an intervention group (neuromuscular electrical stimulation + conventional physical therapy) or a conventional group (sham neuromuscular electrical stimulation + conventional physical therapy). Primary outcome was thickness of the rectus abdominis and chest muscles, determined on cross-sectional ultrasound images before and after the intervention. Results: Eleven patients were included in the intervention group and 14 in the conventional group. After neuromuscular electrical stimulation, rectus abdominis muscle thickness and chest muscle thickness were preserved in the intervention group, whereas there was a significant reduction in thickness in the conventional group, with a significant difference between groups. There was a significant difference between groups in length of stay in the intensive care unit, with shorter length of stay in the intervention group. Conclusion: There was no change in rectus abdominis and chest muscle thickness in the intervention group. A significant decrease was found in these measures in the conventional group.

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Section: Discussionmentioning

confidence: 99%

Use of neuromuscular electrical stimulation to preserve the thickness of abdominal and chest muscles of critically ill patients: A randomized clinical trial

Acqua¹,

Sachetti²,

Santos³

et al. 2017

J Rehabil Med

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show abstract

“…Electrical stimulation, as a form of passive muscular activity, may be more advantageous than current active exercise training regimens because it causes less ventilatory stress [62]. Although extensively researched in chronically ill patients, insufficient research exists in patients with acute critical illness [63]. Future research should compare the efficacy of electrical stimulation vs traditional mobilization therapies or the efficacy of using both together [64].…”

Section: Passive Mobilizationmentioning

confidence: 99%

Early mobilization in the critical care unit: A review of adult and pediatric literature

Cameron¹,

Ball²,

Cepinskas³

et al. 2015

Journal of Critical Care

238

179

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“…In septic patients with mechanical ventilator management, NMES was applied to one lower limb and the other was used as a control limb. Muscle strength and muscle protein synthesis were improved more on Physical Disabilities -Therapeutic Implicationsthe stimulated side limb, although the muscle cross-sectional area and muscle mass decreased in both limbs [125,126]. A previous RCT using NMES indicated increased muscle strength and decreased mechanical ventilator duration and the incidence of ICUAW decreased from 39.3 to 12.5% in the NMES intervention group [127].…”

Section: Neuromuscular Electrical Stimulationmentioning

confidence: 92%

Skeletal Muscle Dysfunction in Critical Illness

Iida¹,

Sakuma²

2017

Physical Disabilities - Therapeutic Implications

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Despite improvements in critical illness survival rates with recent developments in medical care, many patients still have long-term physical disabilities following stays in the intensive care unit (ICU). Critical illness-induced muscle weakness, so-called ICU-acquired weakness (ICU-AW), is a common occurrence in approximately 50% of critically ill patients in the ICU requiring mechanical ventilation for >7 days. ICU-AW contributes to increases in duration of mechanical ventilation and lengths of ICU and hospital stays and may persist among survivors for several years after discharge. Risk factors for ICU-AW include systemic inflammatory responses, severe sepsis, muscle inactivity, hyperglycemia, and use of neuromuscular blockers. Thus, the development of muscle wasting is suggested to be associated with pathophysiological alterations leading to an imbalance between muscle proteolysis and proteosynthesis through several cellular signaling networks. This chapter presents a review of the literature regarding critical illness-induced muscle wasting and describes potential treatment of excessive muscle catabolism.

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Muscle weakness in septic patients requiring mechanical ventilation: Protective effect of transcutaneous neuromuscular electrical stimulation

Cited by 140 publications

References 27 publications

Use of neuromuscular electrical stimulation to preserve the thickness of abdominal and chest muscles of critically ill patients: A randomized clinical trial

Use of neuromuscular electrical stimulation to preserve the thickness of abdominal and chest muscles of critically ill patients: A randomized clinical trial

Early mobilization in the critical care unit: A review of adult and pediatric literature

Skeletal Muscle Dysfunction in Critical Illness

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