Murine T cell receptor beta chain is encoded on chromosome 6.

Lee, N E; D’Eustachio, Peter; Pravtcheva, Dimitrina D.; Ruddle, Frank H.; Hedrick, Stephen M.; Davis, Mark M.

doi:10.1084/jem.160.3.905

Cited by 50 publications

(6 citation statements)

References 40 publications

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“…Our results, together with the recently determined chromosom,al location of the T-cell -chain gene (26,27), show that the known Ig-like genes (a, 13, and y), which rearrange in T cells, are each located on a different mouse chromosome: a on 14, on 6, and y on 13. The three Ig gene families are similarly located on different mouse chromosomes: the genes for H, K, and chains are on chromosomes 12, 6, and 16, respectively (22)(23)(24)(25).…”

supporting

confidence: 68%

“…6, 499 (1981)]. 26 Chromosomal Locations of the Murine T-Cell Receptor Alpha-Chain Gene and the T-Cell Gamma Gene Abstract. Two independent methods were used to identify the mouse chromosomes on which are located two families of immunoglobulin (Ig)-like genes that are rearranged and expressed in T lymphocytes.…”

mentioning

confidence: 99%

“…The three gene families for the Ig subunits [heavy (H), K, and X] are each located on a different chromosome (22)(23)(24)(25). The Tcell 3-chain gene family is located on mouse chromosome 6 (26,27), but the chromosomal location of the a and -y genes has not been known (until now).…”

mentioning

confidence: 99%

“…The T-cell receptor oa-chain gene is on mouse chromosome 14. Chromosome mapping of the a-chain gene was performed by the analyses (29) of mousehamster hybrids (22,23,25,26). DNA from 12 mouse-Chinese hamster hybrid cell lines was examined by Southern blot analysis (29) with a probe corresponding to the combined V and C regions of the rearranged gene for the a chain of cytotoxic T-lymphocyte clone 2C [cDNA clone pHDS 58 (11)].…”

mentioning

confidence: 99%

“…This probe hybrid- (29) of DNA from representative mouse-hamster hybrid cell lines. DNA from mouse (BALB/c), hamster (E36), and mouse-hamster hybrid cell lines (22,23,25,26) was digested with Eco RI, subjected to electrophoresis through a 0.8 percent agarose gel and blotted onto nitrocellulose.…”

mentioning

confidence: 99%

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Chromosomal Locations of the Murine T-Cell Receptor Alpha-Chain Gene and the T-Cell Gamma Gene

Kranz

Saito

Swisshelm

et al. 1985

Science

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Two independent methods were used to identify the mouse chromosomes on which are located two families of immunoglobulin (Ig)-like genes that are rearranged and expressed in T lymphocytes. The genes coding for the alpha subunit of T-cell receptors are on chromosome 14 and the gamma genes, whose function is yet to be determined, are on chromosome 13. Since genes for the T-cell receptor beta chain were previously shown to be on mouse chromosome 6, all three of the Ig-like multigene families expressed and rearranged in T cells are located on different chromosomes, just as are the B-cell multigene families for the Ig heavy chain, and the Ig kappa and lambda light chains. The findings do not support earlier contentions that genes for T-cell receptors are linked to the Ig heavy chain locus (mouse chromosome 12) or to the major histocompatibility complex (mouse chromosome 17).

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supporting

confidence: 68%

mentioning

confidence: 99%

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confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Chromosomal Locations of the Murine T-Cell Receptor Alpha-Chain Gene and the T-Cell Gamma Gene

Kranz

Saito

Swisshelm

et al. 1985

Science

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Variant (6;15) translocations in murine plasmacytomas involve a chromosome 15 locus at least 72 kb from the c-myc oncogene.

Cory¹,

Graham²,

Webb³

et al. 1985

The EMBO Journal

173

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The variant (6;15) translocations in murine plasmacytomas join the myc oncogene‐bearing band of chromosome 15 and the immunoglobulin kappa band of chromosome 6. We recently cloned a region from chromosome 15 linked to C kappa and have now used probes from that region to define the major locus of plasmacytoma variant translocations, which we denote pvt‐1. In five of nine plasmacytomas we analysed, the 6;15 translocation resulted from reciprocal recombination between the C kappa locus and a 4.5‐kb region of pvt‐1. Moreover, nearby we located the region shown by others to have undergone a complex (15;12;6) translocation in plasmacytoma PC7183. All the chromosome 6 breakpoints fell between 1 and 3 kb 5′ to C kappa but only two were near J kappa genes. Thus the J kappa ‐C kappa region appears to be a recombination ‘hot spot’ in lymphocytes, but the breaks are unlikely to be mediated via V/J recombination enzymes. Comparison of a cloned 108‐kb region across pvt‐1 and another of 52 kb across c‐myc established that the pvt‐1 breakpoints lie at least 72 kb from the c‐myc promoters. Since c‐myc is expressed at a substantial level, the 6;15 translocation apparently activates c‐myc. Activation may occur directly, at a remarkable distance along the chromosome, or indirectly, via a putative pvt‐1 gene product.

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Genetic and cytogenetic localisation of the homeo box containing genes on mouse chromosome 6 and human chromosome 7.

Bućan¹,

Yang-Feng²,

Colberg-Poley³

et al. 1986

The EMBO Journal

116

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Probes from the m6 homeo box cluster were mapped to mouse chromosome 6 by somatic cell genetics, in situ hybridisation, and by a Mus spretus‐‐Mus musculus backcross mapping system. In addition, the testis‐specific homeo box containing cDNA, clone, HBT‐1, has been mapped using the same back‐cross system and the B X D recombinant inbred strain set. Close genetic and physical linkage between the m6 cluster and HBT‐1 was demonstrated, positioning these sequences to the same local cluster of homeo box containing genes. The map location of this cluster between IgK and Tcrb coincides with the morphological mutation hypodactyly (Hd). Synteny has been observed between a region of mouse chromosome 6 and the long arm of human chromosome 7 encompassing the markers Cpa, Tcrb and Try‐1. Here we localise human sequences hybridising to the mouse m6 probes to the short arm of chromosome 7, breaking the region of synteny.

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Murine T cell receptor beta chain is encoded on chromosome 6.

Cited by 50 publications

References 40 publications

Chromosomal Locations of the Murine T-Cell Receptor Alpha-Chain Gene and the T-Cell Gamma Gene

Chromosomal Locations of the Murine T-Cell Receptor Alpha-Chain Gene and the T-Cell Gamma Gene

Variant (6;15) translocations in murine plasmacytomas involve a chromosome 15 locus at least 72 kb from the c-myc oncogene.

Genetic and cytogenetic localisation of the homeo box containing genes on mouse chromosome 6 and human chromosome 7.

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