Genetic and cytogenetic localisation of the homeo box containing genes on mouse chromosome 6 and human chromosome 7.

Bućan, Maja; Yang-Feng, T L; Colberg-Poley, Anamaris M.; Wolgemuth, Debra J.; Guénet, Jean-Louis; Francke, Uta; Lehrach, Hans

doi:10.1002/j.1460-2075.1986.tb04585.x

Cited by 116 publications

(19 citation statements)

References 53 publications

(19 reference statements)

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“…Hd results in single-digit feet and greatly reduced forelimbs and hindlimbs in heterozygotes and death in homozygotes (21). Our results, together with those of Bucan et al (6), are consistent with the hypothesis that one or both mutations lie within the Hox-J complex. ADDENDUM IN PROOF Two Hox-1.7 transcripts have been cloned from a guinea pig kidney cDNA library.…”

supporting

confidence: 92%

Murine Hox-1.7 homeo-box gene: cloning, chromosomal location, and expression.

et al. 1987

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A new murine homeo-box, called Hox-1.7, has been identified in a rare cDNA from F9 teratocarcinoma stem cells. The Hox-1.7 homeo-box is 68 and 72% homologous to the Drosophila antennapedia (Antp) and iab-7 homeo-boxes, respectively. A major 2.5-kilobase transcript and several minor transcripts were detected by Northern blot (RNA blot) analysis in adult tissues as well as in midgestational embryos. The posterior spinal cord was found to be a major site of Hox-1.7 expression in 12.5-day-old embryos. Somatic cell hybrids were used to map the Hox-1.7 gene to mouse chromosome 6. Restriction fragment length polymorphisms associated with either the Hox-1.7 gene or the previously known Hox-1 complex were identified. Their distribution patterns in recombinant inbred mouse strains were used to determine the linkage between the two loci as well as to other loci on chromosome 6. This maps Hox-1 and Hox-1.7 close to two mouse loci that affect morphogenesis, postaxial hemimelia (px) and hypodactyly (Hd).

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confidence: 92%

Murine Hox-1.7 homeo-box gene: cloning, chromosomal location, and expression.

et al. 1987

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“…Since F9 cells are nullipotent and thus restricted in their differentiation pathway (Strickland and Mahdavi, 1978;Hogan et al, 1983), mouse embryos were investigated at various stages of development. Specifically, using Northern analyses transient expression of Hox 1.1, Hox 1.2 (Colberg-Poley et al, 1985a,b), Hox 1.3 (M.Fibi, B.Zink, M.Kessel, A.M.Colberg-Poley and P.Gruss, in preparation), Hox 1.4 (Wolgemuth et al, 1986;Rubin et al, 1986;Duboule et al, 1986), Hox 1.5 , Hox 2.1, Hox 2.2 Jackson et al, 1985;Hauser et al, 1985;Krumlauf et al, 1987), and Hox 3.1 (Breier et al, 1986;Awgulewitsch et al, 1986) Hart et al, 1985;Awgulewitsch et al, 1986;Jackson et al, 1985;Krumlauf et al,1987). Recent work with Hox 1.5 also showed expression at day 7.5 and later in spinal cord and mesonephric kidney (Gaunt et al, 1986), as well as in spermatocytes and spermatids of adult male animals (Wolgemuth et al, 1986;Rubin et al, 1986).…”

Section: Introductionmentioning

confidence: 99%

Specific expression of the Hox 1.3 homeo box gene in murine embryonic structures originating from or induced by the mesoderm.

1987

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The murine Hox 1.3 homeo box‐containing gene is expressed largely in mesoderm‐derived or mesoderm‐induced embryonal structures, as evidenced by in situ hybridization techniques. Expression is spatially limited to the thoracic region, specifically to components of segmental origin such as embryonal ribs and vertebrae and their precursors such as the equivalent sclerotomes, somites and somatic condensations. In addition, expression can be found in parts of embryonal lung, stomach tissue, gut and kidney, tissues whose formation is based on induction of region‐specific mesoderm, as well as in some ectoderm‐derived tissues. The expression is temporally controlled for the transcripts and can only be detected while the thoracic structures are being formed (days 8‐13), but not at day 18 of gestation when the embryo is mature. These data suggest a role of Hox 1.3 gene in the generation of tissues derived from or induced by the embryonal mesoderm.

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“…The majority of mammalian genes containing homeo boxes are most closely related to the Antp family. These genes, of which > 18 have been identified, are situated in three major clusters in the mouse genome localized on chromosome 6 (Hox-1) (Colberg-Poley et al 1985;Bucan et al 1986;Baron et al 1987), 11 (Hox-2) Joyner et al 1985;Rabin et al 1985;Munke et al 1986;Meijlink et al 1987), and 15 (Hox-3) (Awgulewitsch et al 1986;Rabin et al 1986;Breier et al 1988), with several others scattered throughout the genome (Hox-4, Hox-5, and Hox-6) {Lonai et al 1987;Featherstone et al 1988;Sharpe et al 1988). Two unlinked genes that map to chromosomes 1 and 5 in the mouse contain homeo boxes homologous to the Drosophila en family Joyner and Martin 1987).…”

mentioning

confidence: 99%

A new family of mouse homeo box-containing genes: molecular structure, chromosomal location, and developmental expression of Hox-7.1.

Hill¹,

Jones²,

Rees³

et al. 1989

Genes Dev.

378

175

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Two families of homeo box-containing genes have been identified in mammals to date, the Antennapedia-and engrailed-like homeo boxes, based on the sequence similarity to those from Drosophila. Here, we report the isolation of a homeo box-containing gene that belongs to a new family of which there are at least three related genes in the mouse genome. The homeo box of this new gene shows remarkable similarity to the Drosophila Msh homeo box that we designate as the prototype for this family. The gene maps to the proximal end of mouse chromosome 5 and does not cosegregate with any known homeo box-containing gene. We designate this locus Hox-7.1. In situ hybridizations to mouse embryos at different stages show a unique pattern of expression, as compared to other homeo box-containing genes described thus far. Hox-7.1 transcripts are detected in 9.5-dayold embryos in the neural crest, developing limb bud, and visceral arches. Later, this gene is expressed in regions of the face that are derived from neural crest and in the interdigital mesenchymal tissues in both the fore-and hindlimbs.

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Genetic and cytogenetic localisation of the homeo box containing genes on mouse chromosome 6 and human chromosome 7.

Cited by 116 publications

References 53 publications

Murine Hox-1.7 homeo-box gene: cloning, chromosomal location, and expression.

Murine Hox-1.7 homeo-box gene: cloning, chromosomal location, and expression.

Specific expression of the Hox 1.3 homeo box gene in murine embryonic structures originating from or induced by the mesoderm.

A new family of mouse homeo box-containing genes: molecular structure, chromosomal location, and developmental expression of Hox-7.1.

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