Multiwall carbon nanotube scaffolds for tissue engineering purposes

Abarrategi, Ander; Gutiérrez, Marı́a C.; Moreno-Vicente, Carolina; Hortigüela, María J.; Ramos, Viviana; López-Lacomba, José Luís; Ferrer, M. Luisa; Monte, Francisco del

doi:10.1016/j.biomaterials.2007.09.021

Cited by 399 publications

(261 citation statements)

References 65 publications

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“…80,[109][110][111][112] Thus, the GO fiber impregnation strategy described here is very appealing for the fabrication of functional bio-coatings whose physicochemical properties could be suitably tuned by controlling the density, structural and chemical features of the attached CNT materials.…”

Section: Discussion Of Potential Applications Of Hybrid Composites Anmentioning

confidence: 99%

Multifunctional, biocompatible and pH-responsive carbon nanotube- and graphene oxide/tectomer hybrid composites and coatings

et al. 2017

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Section: Discussion Of Potential Applications Of Hybrid Composites Anmentioning

confidence: 99%

Multifunctional, biocompatible and pH-responsive carbon nanotube- and graphene oxide/tectomer hybrid composites and coatings

et al. 2017

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“…(Mu et al, 2009;Heister et al,2009) Such systems have been loaded with drug molecules such as doxorubicin (DOX) via p-p stacking interactions, methotrexate, Paclitaxel and quercetin. (Modi et al, 2011;Yuan et al, 2006;Abarrategi et al, 2008;Fu et al, 2007). Nevertheless, the first generation SWCNTs proved to be unsuitable as drug delivery vectors as they tended to form bundles that disperse poorly in aqueous solutions and were therefore unsuitable for pharmacological use.…”

Section: Carbon Nanotubes and Their Impor-tance In Anticancer Drug Dementioning

confidence: 99%

“…Nevertheless, the first generation SWCNTs proved to be unsuitable as drug delivery vectors as they tended to form bundles that disperse poorly in aqueous solutions and were therefore unsuitable for pharmacological use. To overcome this drawback, synthetic polymers such as poly(phenylacetylene) (Zeineldin et al, 2009, Yuan et al, 2006 and natural polymers such as polysaccharides Yuan et al, 2006;Abarrategi et al, 2008;Fu et al, 2007;Hasegawa et al, 2004;Long et al, 2008;Numata et al, 2004;Zhang et al, 2008) have been used to encase SWCNTs via non-covalent interactions, thereby improving their compatibility with water and physiological environments.…”

Section: Carbon Nanotubes and Their Impor-tance In Anticancer Drug Dementioning

confidence: 99%

Carbon nanotubes as a novel drug delivery system for anticancer therapy: a review

Kushwaha¹,

Ghoshal²,

Kumar³

et al. 2013

Braz. J. Pharm. Sci.

108

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Carbon nanotubes (CNTs) were discovered in 1991 and shown to have certain unique physicochemical properties, attracting considerable interest in their application in various fields including drug delivery. The unique properties of CNTs such as ease of cellular uptake, high drug loading, thermal ablation, among others, render them useful for cancer therapy. Cancer is one of the most challenging diseases of modern times because its therapy involves distinguishing normal healthy cells from affected cells. Here, CNTs play a major role because phenomena such as EPR, allow CNTs to distinguish normal cells from affected ones, the Holy Grail in cancer therapy. Considerable work has been done on CNTs as drug delivery systems over the last two decades. However, concerns over certain issues such as biocompatibility and toxicity have been raised and warrant extensive research in this field.Uniterms: Carbon nanotubes/properties. Carbon nanotubes/use/drugs delivery. Single-Walled Carbon Nanotube. Multiwalled Carbon Nanotube. Anticancer drugs/delivery. Cancer/therapy. Drugs/delivery.Os nanotubos de carbono foram descobertos em 1991 e suas propriedades físico-químicas únicas demonstradas, despertando interesse em sua aplicação em vários campos, incluindo a entrega liberação de fármacos. As propriedades únicas dos nanotubos de carbono, tais como a facilidade de captação pela célula, carga alta de fármaco, ablação térmica, entre outras, tornaram-nos úteis para terapia de câncer, uma das doenças mais difíceis dos tempos modernos, pois sua terapia envolve a distinção entre as células normais saudáveis e as afetadas pela doença. Os nanotubos de carbono têm um papel importante nessa área porque fenômenos como EPR permitem que estes possam distinguir as células normais das afetadas, que é o Santo Graal na terapia do câncer. Trabalho considerável tem sido feito ao longo das duas últimas década com nanotubos de carbono, como sistemas de liberação de fármacos. No entanto, preocupações sobre algumas questões, como biocompatibilidade e toxicidade, surgiram ao longo do tempo, demandando extensas pesquisa nesse campo. Unitermos: Nanotubos de carbono/propriedades. Nanotubos de carbono/uso/liberação de fármacos. Nanotubo de carbono de parede única. Nanotubo de parede múltipla. Fármacos anticancer/liberação. Cancer/tratamento. Fármacos/liberação.

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“…Cell adhesion, viability and proliferation onto the external surface of MWCNT/CHI scaffolds with C2C12 cell line (myoblastic mouse cell), which is a multipotent cell line able to differentiate towards different phenotypes under the action of some chemical or biological factors, has been evaluated in vitro and quantified by MTT assays. The evolution of the C2C12 cell line towards an osteoblastic lineage in presence of the recombinant human bone morphogenetic protein-2 (rhBMP-2) has also been studied both in vitro (e.g., following the appearance of alkaline phosphatase activity) and in vivo (e.g., by implantation of MWCNT/chitosan scaffolds adsorbed with rhBMP-2 in muscle tissue and evaluation of the ectopic formation of bone tissue) (Abarrategi, et al 2008). …”

Section: Biopolymer/cnt Composite As Tissue Scaffoldsmentioning

confidence: 99%