Multivariate optimization of surfactant‐assisted directly suspended droplet microextraction combined with GC for the preconcentration and determination of tramadol in biological samples

Ebrahimzadeh, Homeira; Mollazadeh, Narges; Asgharinezhad, Ali Akbar; Shekari, Nafiseh; Mirbabaei, Fatemeh

doi:10.1002/jssc.201300810

Cited by 27 publications

(11 citation statements)

References 37 publications

(26 reference statements)

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“…Tramadol, (1R,2R)‐2‐[(dimethyl amino)methyl]‐1‐(3‐methoxyphenyl) cyclohexanol, is a synthetic monoamine neurotransmitter with selective activity at the μ‐opioid receptors (Supporting Information Figure S1a). This substance is utilized typically as an opioid pain medication in the treatment of mild pain . It performs by blocking the reuptake of norepinephrine and serotonin which contributes to the drug's analgesic effect .…”

Section: Introductionmentioning

confidence: 99%

Mixed hemimicelle magnetic dispersive solid‐phase extraction using carbon‐coated magnetic nanoparticles for the determination of tramadol in urine samples

Taghvimi

Hamidi

Javadzadeh

2018

J of Separation Science

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Ionic liquid carbon‐coated magnetic nanoparticles were successfully applied as an adsorbent in a mixed hemimicelle magnetic dispersive solid‐phase extraction method for the determination of tramadol from urine samples coupled with high‐performance liquid chromatography with UV‐vis detection. The significant parameters affect the extraction efficiency including type and amount of adsorbent, sample volume, pH, ionic strength, type and amount of elution solvent, time of extraction and desorption, time of ionic liquid loading on the adsorbent and stirring rate were studied and optimized. The proposed method provided a fast, straightforward, environmentally friendly and adsorbent recyclable approach for tramadol analysis. The linear range for the tramadol determination was from 100 to 1500 ng/mL. Precisions and accuracies were within 6%. The applicability of the proposed method in clinical trial was tried successfully on determination of tramadol in addicted subjects under tramadol therapy. The mean percent recovery of the patient samples was 94%. The results proved that the proposed method could be applied in clinical and forensic laboratories for determination of tramadol from biological urine samples.

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Section: Introductionmentioning

confidence: 99%

Mixed hemimicelle magnetic dispersive solid‐phase extraction using carbon‐coated magnetic nanoparticles for the determination of tramadol in urine samples

Taghvimi

Hamidi

Javadzadeh

2018

J of Separation Science

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“…Desirability value was used as the response and based on this value the optimum sorption conditions were evaluated. Based on N = 2 f +2 f + C 0 , in which f is the number of factors and C 0 is the number of center point; f and C 0 were adjusted to 4 and 6, respectively, which means that 30 tests should be carried out . The obtained experimental data exhibited a good agreement with the quadratic polynomial model.…”

Section: Resultsmentioning

confidence: 91%

Computer‐aided design and synthesis of a highly selective molecularly imprinted polymer for the extraction and determination of buprenorphine in biological fluids

Ganjavi

Ansari

Kazemipour

et al. 2017

J of Separation Science

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Buprenorphine is widely used to aid the cessation of opioids in addicted patients. To the best of our knowledge, there is no selective extraction method for buprenorphine from biological fluids. Here, we describe the synthesis of a molecularly imprinted polymer with the aid of computational design and its application for selective extraction of buprenorphine from plasma and urine. Computational design was used to study intermolecular interactions in the pre-polymerization mixture by the comparison of the binding energy between buprenorphine (template) and functional monomers. The largest interaction energy of template-monomers was obtained at ratio of 1:5 buprenorphine/acrylic acid monomers. Afterwards, the molecularly imprinted polymer was synthesized through precipitation polymerization technique and was employed for selective extraction of buprenorphine. Optimization of various parameters of the molecularly imprinted polymer solid-phase extraction of buprenorphine was carried out by a design of experiment approach using a central composite design and the analyte was determined by employing high-performance liquid chromatography with UV detection. Equilibrium isotherms were studied, and results revealed that the sorption process was in adoption with Langmuir model. Maximum enrichment capacity and Langmuir constant were calculated as 18.2 mg/g and 0.797 L/mg, respectively. Kinetic studies indicated the sorption process followed a pseudo-second-order model.

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“…The analytical data, such as preconcentration factors (PFs), linear dynamic ranges (LDRs), regression equations, correlation coefficients ( r 2 ), the LODs, and extraction recoveries (ER%) were obtained. The preconcentration factor and extraction recovery (ER%) were calculated based on the following equations :

PF = \frac{c_{f}}{c_{i}}

(ER) % = (\frac{c_{f} \times v_{f}}{c_{i} \times V v_{i}}) = PF \times (\frac{V_{f}}{V_{i}})

…”

Section: Resultsmentioning

confidence: 99%

Surfactant-assisted dispersive liquid-liquid microextraction of nitrazepam and lorazepam from plasma and urine samples followed by high-performance liquid chromatography with UV analysis

et al. 2015

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Surfactant-assisted liquid-liquid microextraction followed by high-performance liquid chromatography with UV detection has been developed for the simultaneous preconcentration and determination of lorazepam and nitrazepam in biological fluids. In this study, an ionic surfactant (cetyltrimethyl ammonium bromide) was used as an emulsifier. The predominant parameters affecting extraction efficiency such as the type and volume of extraction solvent, the type and concentration of surfactant, sample pH, and the concentration of salt added to the sample were investigated and opted. Under the optimum conditions (extraction solvent and its volume, 1-octanol, 70 μL; surfactant and its concentration, 1 mL of ultra-pure water containing 2 mmol L cetyltrimethyl ammonium bromide; sample pH = 9 and salt content of 10% NaCl w/v), the preconcentration factors were obtained in the range of 202-241 and 246-265 for nitrazepam and lorazepam, respectively. The limits of quantification for both drugs were 5 μg L in water sample and 10 μg L in biological fluids with R values higher than 0.993. The suitability of the proposed method was successfully confirmed by the extraction and determination of the target drugs in human urine and plasma samples in the range of microgram per liter.

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Multivariate optimization of surfactant‐assisted directly suspended droplet microextraction combined with GC for the preconcentration and determination of tramadol in biological samples

Cited by 27 publications

References 37 publications

Mixed hemimicelle magnetic dispersive solid‐phase extraction using carbon‐coated magnetic nanoparticles for the determination of tramadol in urine samples

Mixed hemimicelle magnetic dispersive solid‐phase extraction using carbon‐coated magnetic nanoparticles for the determination of tramadol in urine samples

Computer‐aided design and synthesis of a highly selective molecularly imprinted polymer for the extraction and determination of buprenorphine in biological fluids

Surfactant-assisted dispersive liquid-liquid microextraction of nitrazepam and lorazepam from plasma and urine samples followed by high-performance liquid chromatography with UV analysis

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