Surfactant-assisted dispersive liquid-liquid microextraction of nitrazepam and lorazepam from plasma and urine samples followed by high-performance liquid chromatography with UV analysis

Molaei, Karam; Asgharinezhad, Ali Akbar; Ebrahimzadeh, Homeira; Shekari, Nafiseh; Jalilian, Niloofar; Dehghani, Zahra

doi:10.1002/jssc.201500586

Cited by 28 publications

(16 citation statements)

References 51 publications

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“…Relative recovery percentage (RR%) was calculated based on the following equation .

RR % = \frac{C_{found} - C_{real}}{C_{added}} \times 100

where C found , C real , and C added are concentration of target analyte after adding a known amount of standard into the real sample, concentration of target analyte in real sample, and the concentration of a known amount of standard, which was spiked into the real sample, respectively.…”

Section: Resultsmentioning

confidence: 99%

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Magnetic molecularly imprinted composite for the selective solid-phase extraction ofp-aminosalicylic acid followed by high-performance liquid chromatography with ultraviolet detection

et al. 2016

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A new method for the selective extraction of p-aminosalicylic acid from aqueous and urine samples has been developed using magnetic molecularly imprinted polymer nanoparticles before determination by high-performance liquid chromatography. The Fe O nanoparticles were first prepared through the chemical coprecipitation of Fe and Fe and then coated with a vinyl shell. Subsequently, a layer of molecularly imprinted polymers was grafted onto the vinyl-modified magnetic nanoparticles by precipitation polymerization. FTIR spectroscopy, scanning electron microscopy, vibrating sample magnetometry, and thermogravimetric analysis were applied to characterize the sorbent properties. Moreover, the predominant parameters affecting the magnetic solid phase extraction such as sample pH, sorption and elution times, the amount of sorbent, and composition and volume of eluent were investigated thoroughly. The maximum sorption capacity of the imprinted polymer toward p-aminosalicylic acid was 70.9 mg/g, which is 4.5 times higher than that of the magnetic nonimprinted polymer. The magnetic molecularly imprinted polymer nanoparticles were applied for the selective extraction of p-aminosalicylic acid from aqueous and urine samples and satisfactory results were achieved. The results illustrate that magnetic molecularly imprinted polymer nanoparticles have a great potential in the extraction of p-aminosalicylic acid from environmental and biological matrices.

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“…Relative recovery percentage (RR%) was calculated based on the following equation .

RR % = \frac{C_{found} - C_{real}}{C_{added}} \times 100

Section: Resultsmentioning

confidence: 99%

“…To assess matrix effects, the accuracy of the MSPE-HPLC method was investigated by performing recovery tests at two different concentrations (5 and 50 g/L) of PAS in wastewater and urine samples. Relative recovery percentage (RR%) was calculated based on the following equation [44].…”

Section: Application To Real Sample Analysismentioning

confidence: 99%

Magnetic molecularly imprinted composite for the selective solid-phase extraction ofp-aminosalicylic acid followed by high-performance liquid chromatography with ultraviolet detection

et al. 2016

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“…However, continued use of BZPs may have adverse effects, such as drowsiness, dizziness, and decreased alertness. Furthermore, BZPs are readily available, which increases their potential for addiction . Besides, BZPs may also find their way into our environment, since they are excreted partially unchanged, and thus have been detected in wastewaters .…”

Section: Introductionmentioning

confidence: 99%

Fabrication of magnetic zinc adeninate metal–organic frameworks for the extraction of benzodiazepines from urine and wastewater

Zhang

Yao

Fu³

et al. 2018

J of Separation Science

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In this study, an alternative method for synthesizing magnetic cobalt adeninate metal-organic frameworks was developed, and the synthesized materials were examined for their potential application for separating and enriching benzodiazepines from complex samples. Benzodiazepines, widely used as hypnotics, muscle relaxants, sedatives, and anxiolytics, are a class of drugs that require accurate detection and monitoring. Results showed that Fe O nanoparticles could be well anchored onto the external surface of cobalt adeninate metal-organic frameworks by using amino-silane as a linkage. Their adsorption of benzodiazepines was mainly promoted by intermolecular hydrogen binding, π-π interactions and electrostatic attraction. Their potential application was evaluated by extraction of benzodiazepines in urine and wastewater samples prior to liquid chromatography with mass spectrometry. Under optimum conditions, the calibration curves were linear with a correlation coefficient of ≥0.9928 in the concentration range of 10-5000 ng/L for lorazepam and 5-5000 ng/L for estazolam, chlordiazepoxide, alprazolam, midazolam and triazolam. The limits of detection were in the range of 0.71-2.49 ng/L. The percent of extraction recoveries were 80.2-94.5% for urine and 84.1-94.4% for wastewater, respectively. Results suggested that magnetic cobalt adeninate metal-organic frameworks could potentially be a promising material for enriching benzodiazepines from urine and wastewater with high accuracy and precision.

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“…By manual shaking, the sugar is dissolved, and the extractant is released into the aqueous solution as notably tiny droplets. In surfactant‐assisted DLLME (SA‐DLLME), a surfactant is used as the dispersive agent . Surfactants are organic compounds that contain both hydrophilic and hydrophobic groups, and they are soluble in both organic solvents and water.…”

Section: Introductionmentioning

confidence: 99%

Cyclodextrin‐assisted dispersive liquid–liquid microextraction for the preconcentration of carbamazepine and clobazam with subsequent sweeping micellar electrokinetic chromatography

Chen

Chang

2018

J of Separation Science

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A new version of dispersive liquid-liquid microextraction, namely, cyclodextrin-assisted dispersive liquid-liquid microextraction, with subsequent sweeping micellar electrokinetic chromatography has been developed for the preconcentration and sensitive detection of carbamazepine and clobazam. α-Cyclodextrin and chloroform were used as the dispersive agent and extraction solvent, respectively. After the extraction, carbamazepine and clobazam were analyzed using micellar electrokinetic chromatography with ultraviolet detection. The detection sensitivity was further enhanced using the sweeping technique. Under optimal extraction and stacking conditions, the calibration curves of carbamazepine and clobazam were linear over a concentration range of 2.0-200.0 ng/mL. The method detection limits at a signal-to-noise ratio of 3 were 0.6 and 0.5 ng/mL with sensitivity enhancement factors of 3575 and 4675 for carbamazepine and clobazam, respectively. This developed method demonstrated high sensitivity enhancement factors and was successfully applied to the determination of carbamazepine and clobazam in human urine samples. The precision and accuracy for urine samples were less than 4.2 and 6.9%, respectively.

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Surfactant-assisted dispersive liquid-liquid microextraction of nitrazepam and lorazepam from plasma and urine samples followed by high-performance liquid chromatography with UV analysis

Cited by 28 publications

References 51 publications

Magnetic molecularly imprinted composite for the selective solid-phase extraction ofp-aminosalicylic acid followed by high-performance liquid chromatography with ultraviolet detection

Magnetic molecularly imprinted composite for the selective solid-phase extraction ofp-aminosalicylic acid followed by high-performance liquid chromatography with ultraviolet detection

Fabrication of magnetic zinc adeninate metal–organic frameworks for the extraction of benzodiazepines from urine and wastewater

Cyclodextrin‐assisted dispersive liquid–liquid microextraction for the preconcentration of carbamazepine and clobazam with subsequent sweeping micellar electrokinetic chromatography

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