Multiple variable effects in the customisation of fused deposition modelling 3D-printed medicines: A design of experiments (DoE) approach

Santos, Juliana dos; Deon, Marion; Silva, Guilherme Silveira da; Beck, Ruy Carlos Ruver

doi:10.1016/j.ijpharm.2021.120331

Cited by 21 publications

(17 citation statements)

References 40 publications

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“…In pharmacy, FDM combined with HME and optimized formulation compositions have also recently shown to be an attractive option for the development of pharmaceutical tablets and implants where adjustable drug release patterns are required [56][57][58][59]. FDM coupled with passive diffusion has shown to be an accessible loading method for filaments to allow for the manufacture of tailored personalised medicines in clinical settings [60].…”

Section: Introductionmentioning

confidence: 99%

Fused deposition modelling: Current status, methodology, applications and future prospects

Cano-Vicent

Tambuwala

Hassan³

et al. 2021

Additive Manufacturing

181

126

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Section: Introductionmentioning

confidence: 99%

Fused deposition modelling: Current status, methodology, applications and future prospects

Cano-Vicent

Tambuwala

Hassan³

et al. 2021

Additive Manufacturing

181

126

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“…The most used techniques for the development of medicines are the extrusion techniques—semisolid extrusion and FDM, stereolithography, inkjet printing and selective laser sintering (SLS) [ 15 ]. Thanks to the versatility of 3D printing in the development of personalized medicines, it has been used in the production of the most diverse pharmaceutical forms, such as oral delivery devices (tablets, caplets, and printlets) [ 16 , 17 , 18 , 19 ], skin products (films, microneedles and patches) [ 20 , 21 ], implants [ 22 , 23 ], and scaffolds [ 24 , 25 ], among others.…”

Section: Introductionmentioning

confidence: 99%

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

et al. 2021

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Eudragit® polymers are polymethacrylates highly used in pharmaceutics for the development of modified drug delivery systems. They are widely known due to their versatility with regards to chemical composition, solubility, and swelling properties. Moreover, Eudragit polymers are thermoplastic, and their use has been boosted in some production processes, such as hot melt extrusion (HME) and fused deposition modelling 3D printing, among other 3D printing techniques. Therefore, this review covers the studies using Eudragit polymers in the development of drug delivery systems produced by HME and 3D printing techniques over the last 10 years. Eudragit E has been the most used among them, mostly to formulate immediate release systems or as a taste-masker agent. On the other hand, Eudragit RS and Eudragit L100-55 have mainly been used to produce controlled and delayed release systems, respectively. The use of Eudragit polymers in these processes has frequently been devoted to producing solid dispersions and/or to prepare filaments to be 3D printed in different dosage forms. In this review, we highlight the countless possibilities offered by Eudragit polymers in HME and 3D printing, whether alone or in blends, discussing their prominence in the development of innovative modified drug release systems.

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“…The main polymers reported for this technique are PVA (poly(vinyl alcohol)), PLA (polylactic acid) and EVA (Ethylene Vinyl Acetate) [69]. Moreover, PCL (polycaprolactone) [70,71] and polymethacrylates, as Eudragit ® [72] are being well explored in the pharmaceutical field due to their versatility. On the Encouraged by the development of 3D printing technology, a great range of polymers are arising to achieve diverse requirements of biomedical applications [58].…”

Section: D Printing Techniquesmentioning

confidence: 99%

3D-Printed Products for Topical Skin Applications: From Personalized Dressings to Drug Delivery

et al. 2021

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3D printing has been widely used for the personalization of therapies and on-demand production of complex pharmaceutical forms. Recently, 3D printing has been explored as a tool for the development of topical dosage forms and wound dressings. Thus, this review aims to present advances related to the use of 3D printing for the development of pharmaceutical and biomedical products for topical skin applications, covering plain dressing and products for the delivery of active ingredients to the skin. Based on the data acquired, the important growth in the number of publications over the last years confirms its interest. The semisolid extrusion technique has been the most reported one, probably because it allows the use of a broad range of polymers, creating the most diverse therapeutic approaches. 3D printing has been an excellent field for customizing dressings, according to individual needs. Studies discussed here imply the use of metals, nanoparticles, drugs, natural compounds and proteins and peptides for the treatment of wound healing, acne, pain relief, and anti-wrinkle, among others. The confluence of 3D printing and topical applications has undeniable advantages, and we would like to encourage the research groups to explore this field to improve the patient’s life quality, adherence and treatment efficacy.

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Multiple variable effects in the customisation of fused deposition modelling 3D-printed medicines: A design of experiments (DoE) approach

Cited by 21 publications

References 40 publications

Fused deposition modelling: Current status, methodology, applications and future prospects

Fused deposition modelling: Current status, methodology, applications and future prospects

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

3D-Printed Products for Topical Skin Applications: From Personalized Dressings to Drug Delivery

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