Multiple sclerosis, and other demyelinating and autoimmune inflammatory diseases of the central nervous system

Matute-Blanch, Clara; Montalbán, Xavier; Comabella, Manuel

doi:10.1016/b978-0-12-804279-3.00005-8

Cited by 34 publications

(30 citation statements)

References 150 publications

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“…Our observations in the case of this patient endorse the fact that in the etiopathogeny of MS, in addition to inflammatory processes, oxidative stress mechanisms are involved and that the seriousness of the disease is also associated with the intensity of that stress ( 29 – 31 ). It would similarly confirm that rTMS therapy would exert an objectifiable clinical improvement on MS and that such improvement would, in turn be related to a diminution in oxidative stress.…”

Section: Discussionsupporting

confidence: 71%

Impact of Repetitive Transcranial Magnetic Stimulation on Neurocognition and Oxidative Stress in Relapsing-Remitting Multiple Sclerosis: A Case Report

et al. 2020

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Multiple sclerosis (MS) is a neurodegenerative condition whose manifestation and clinical evolution can present themselves in very different ways. Analogously, its treatment has to be personalized and the patient's response may be idiosyncratic. At this moment there is no cure for it, in addition to its clinical course sometimes being torpid, with a poor response to any treatment. However, Transcranial Magnetic Stimulation (TMS) has demonstrated its usefulness as a non-invasive therapeutic tool for the treatment of some psychiatric and neurodegenerative diseases. Some studies show that the application of rTMS implies improvement in patients with MS at various levels, but the effects at the psychometric level and the redox profile in blood have never been studied before, despite the fact that both aspects have been related to the severity of MS and its evolution. Here we present the case of a woman diagnosed with relapsing-remitting multiple sclerosis (RRMS) at the age of 33, with a rapid progression of her illness and a poor response to different treatments previously prescribed for 9 years. In view of the patient's clinical course, a compassionate treatment with rTMS for 1 year was proposed. Starting from the fourth month of treatment, when reviewing the status of her disease, the patient denoted a clear improvement at different levels. There followed out psychometric evaluations and blood analyses, that showed both an improvement in her neuropsychological functions and a reduction in oxidative stress in plasma, in correspondence with therTMS treatment.

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Section: Discussionsupporting

confidence: 71%

Impact of Repetitive Transcranial Magnetic Stimulation on Neurocognition and Oxidative Stress in Relapsing-Remitting Multiple Sclerosis: A Case Report

et al. 2020

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“…За последние 10-15 лет отмечен существенный прогресс в лечении РС. Благодаря разработке современных подходов, опирающихся на знание иммунопатогенеза РС и результаты мультицентровых клинических исследований [22,23], организованных по правилам доказательной медицины, стало возможным контролировать активность РС. Появились новые лекарственные средства патогенетического лечения РС -препараты, изменяющие течение РС (ПИТРС).…”

Section: клиника и диагностикаunclassified

The improvement of quality of life of patients with multiple sclerosis over 15-year period

Boyko

Tatarinova

Popova

et al. 2018

Z. nevrol. psikhiatr. im. S.S. Korsakova

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“…The restless leg syndrome (or Wills-Ekbom disease), is a continuous progressive movement disease that is provoked by the need to propel the legs during sleep and rest [1][2][3] . Multiple sclerosis (MS) is known as an inflammatory, neurodegenerative, and autoimmune disorder that is caused in the nervous system 4,5 . Clinical conditions related to MS, such as stress, depression, exhaustion, and sleep complications, adversely affect the life quality of patients 6 .…”

Section: Introductionmentioning

confidence: 99%

Alpha-synuclein levels in multiple sclerosis patients with restless leg syndrome

Çakına

Yücel

Polat

et al. 2020

Cukurova Medical Journal

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The restless legs syndrome is more frequent and critical in Multiple Sclerosis patients, and it harms their general well-being and life quality. Alpha-synuclein is a synuclein protein that can have an impact on the pathway of signaling, affecting the Dopamin 2 receptor and its receptor trafficking. Studies have shown that the decrease in dopamine 2 receptor and Restless Legs Syndrome disease are correlated. This study is aimed to ascertain the alpha-synuclein level in multiple sclerosis patients with restless legs syndrome. Materials and Methods: We took blood samples from 40 multiple sclerosis patients and 20 healthy individuals. Half of the patient group had Multiple Sclerosis with restless leg syndrome. In the study groups, the alpha-synuclein level was determined by quantitative real-time polymerase chain reaction (qRT-PCR) and enzyme-dependent immunosorbent assay (ELISA). Results: Alpha-synuclein gene expression level was found or be significantly lower in restless leg syndrome patients with multiple sclerosis than the Alpha-synuclein gene expression level in the control group. Conclusion: Alpha-synuclein may have an impact on the pathogenesis of the restless leg syndrome of multiple sclerosis disease. Further investigations are required to determine the impact of alpha-synuclein in the pathogenesis of restless leg syndrome in multiple sclerosis disease.

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Multiple sclerosis, and other demyelinating and autoimmune inflammatory diseases of the central nervous system

Cited by 34 publications

References 150 publications

Impact of Repetitive Transcranial Magnetic Stimulation on Neurocognition and Oxidative Stress in Relapsing-Remitting Multiple Sclerosis: A Case Report

Impact of Repetitive Transcranial Magnetic Stimulation on Neurocognition and Oxidative Stress in Relapsing-Remitting Multiple Sclerosis: A Case Report

The improvement of quality of life of patients with multiple sclerosis over 15-year period

Alpha-synuclein levels in multiple sclerosis patients with restless leg syndrome

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