Multiple Sclerosis and Behavior

Pinkston, James B.; Kablinger, Anita S.; Alekseeva, Nadejda

doi:10.1016/s0074-7742(07)79014-1

Cited by 16 publications

(17 citation statements)

References 78 publications

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“…Some BD symptoms are present in MS patients throughout the evolution of the illness. For example, impulsivity is a common manifestation in patients with MS [44] and emotional lability may occur with the MS exacerbations [2].…”

Section: Psychiatric Disordersmentioning

confidence: 99%

Neuropsychiatric Symptoms of Multiple Sclerosis: State of the Art

Silveira¹,

Guedes²,

Maia³

et al. 2019

Psychiatry Investig

110

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Multiple Sclerosis (MS) is a chronic disabling neuroinflammatory disease. Psychiatric manifestations have a high prevalence in MS patients and may worsen the illness progression and the patients’ quality of life (QoL). Depression is a highly prevalent condition in MS patients, associated with poorer adherence to treatment, decreased functional status and QoL, and increased suicide risk. Diagnosis and treatment of this disorder is challenging because of symptom overlap. Other prevalent psychiatric comorbidities are anxiety disorders, bipolar disorder, psychotic disorders, substance misuse and personality disorders. As the illness progresses, personality changes can happen, as well as affect abnormalities. Cognitive changes occur frequently in MS patients, and affect features like processing speed, attention, learning, memory, visual spatial capabilities, and some language deficits. Disease-modifying treatments may reduce cognitive impairment because of their container action on the brain’s lesion burden. Other QoL determinants such as fatigue, pain, sexual dysfunction, exercise, resilience and social support should be taken into account, in order to promote the individuals’ well-being. Further studies are needed in order to elucidate the effectiveness of pharmacotherapy and more neuroimaging studies are required to clarify the relationship between structural changes and psychiatric comorbidities.

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Section: Psychiatric Disordersmentioning

confidence: 99%

Neuropsychiatric Symptoms of Multiple Sclerosis: State of the Art

Silveira¹,

Guedes²,

Maia³

et al. 2019

Psychiatry Investig

110

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“…In Multiple Sclerosis (MS), a chronic neurological disease characterized by demyelination, axonal loss [1] and grey matter atrophy [2], fatigue reportedly affects between 80-95% of the population [3, 4]. Fatigue may be the most common [5] and debilitating [6] symptom in MS and is a predictor of unemployment [7]. Hence, identifying mechanisms of fatigue is paramount as a prelude for risk assessment and interventions.…”

Section: Introductionmentioning

confidence: 99%

The relationship between subjective reports of fatigue and executive control in Multiple Sclerosis

Holtzer

Foley

2009

Journal of the Neurological Sciences

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Previous studies failed to show a relationship between fatigue and cognitive performance. We used a theory-based Delayed Item Recognition (DIR) paradigm to examine the hypothesis that subjective reports of fatigue and executive control processes were related in MS. Participants were 20 individuals diagnosed with definite diagnosis of MS with Relapsing-Remitting course and 20 controls case matched for age, sex, education and IQ. The DIR paradigm manipulated executive demands in three conditions: Alone, Partial Interference (PI), and Complete Interference (CI). Fatigue was assessed using the Fatigue Severity Scale (FSS). Results: ANOVA Repeated measures analyses showed that DIR performance was slower and less accurate as a function of MS and increased executive demands across the three task conditions. Separate linear regressions revealed that fatigue was related to DIR reaction time and accuracy performance only in the CI condition where executive demands are maximized, and only in the MS group. The present study provided first behavioral evidence that fatigue and executive control are uniquely related in MS.

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“…Psychiatric disorders have been described in MS, including symptoms of depression, bipolar disorder, euphoria, pathological laughter and crying, and psychosis as well as maladaptive personality traits 2 . The prevalence of pathological laughing and crying in MS is 10% 3 .…”

Section: Introductionmentioning

confidence: 99%

Pathological Laughing As a Manifestation in a Clinically Isolated Brainstem Syndrome: A Case Report

Koçer¹,

Oner²,

Batur³

et al. 2009

Journal of Neuroimaging

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The prevalence of pathological laughing and crying in multiple sclerosis (MS) is 10%. It has been speculated that the anatomical lesion responsible for the pathological laughing is located in the pontine base, prefrontal cortex, and cerebellum. We report an 18-year-old male patient presenting with pathological laughing and hypomania. In his neurological examination, he had a euphoric effect with ataxic walking and dysarthria speech. He had a bilateral conjugated gaze limitation, with a prominent bilateral horizontal nystagmus on left gaze, dysmetria, dysdiadokokinesia, and remarkable dysfunction in a heel-to-shin test on the left. The IgG index in cerebrospinal fluid was normal with an oligoclonal band was present. In cranial MRI, there was a lesion on central pons which was hypointense in T1 images with contrast enhancement and hyperintense in T2 and flair images. Also another lesion in right brachium pontis which did not contrast enhancement but was hyperintense on T2 and flair images was present. There was an elevation of myoinositol/creatine ratio and choline and a reduction of NAA in proton MR spectroscopy. MR spectroscopic evaluation of the patient demonstrated the demyelination process. There has been no report of patients in whom pathological laughter was the presenting symptom of clinically isolated brainstem syndrome.

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Multiple Sclerosis and Behavior

Cited by 16 publications

References 78 publications

Neuropsychiatric Symptoms of Multiple Sclerosis: State of the Art

Neuropsychiatric Symptoms of Multiple Sclerosis: State of the Art

The relationship between subjective reports of fatigue and executive control in Multiple Sclerosis

Pathological Laughing As a Manifestation in a Clinically Isolated Brainstem Syndrome: A Case Report

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