Multiple Pyogenic Liver Abscesses Caused by<i>Eggerthella lenta</i>Treated with Ertapenem: A Case Report

Eliáš, Richard; Khoo, Shiao-Yen; Pupaibool, Jakrapun; Nienaber, Ju Hsien; Cummins, Nathan W.

doi:10.1155/2012/718130

Cited by 11 publications

(8 citation statements)

References 9 publications

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“…Two describe severe, disseminated disease with multifocal abscesses requiring extended courses of intravenous antibiotics and/or surgical drainage to cure (12,38). There are other published cases of severe E. lenta infection without definite bacteremia, including reports of frontal sinusitis (43), pyomyositis (44), cutaneous abscesses (45), spondylodiscitis (46), and liver abscess (47). E. lenta has also been implicated in the pathogenesis of bacterial vaginosis (48)(49)(50) and linked to appendicitis in children (51).…”

Section: Discussionmentioning

confidence: 99%

Clinical and Microbiological Characteristics of Eggerthella lenta Bacteremia

et al. 2015

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e Eggerthella lenta is an emerging pathogen that has been underrecognized due to historical difficulties with phenotypic identification. Until now, its pathogenicity, antimicrobial susceptibility profile, and optimal treatment have been poorly characterized. In this article, we report the largest cohort of patients with E. lenta bacteremia to date and describe in detail their clinical features, microbiologic characteristics, treatment, and outcomes. We identified 33 patients; the median age was 68 years, and there was no gender predominance. Twenty-seven patients (82%) had serious intra-abdominal pathology, often requiring a medical procedure. Of those who received antibiotics (28/33, 85%), the median duration of treatment was 21.5 days. Mortality from all causes was 6% at 7 days, 12% at 30 days, and 33% at 1 year. Of 26 isolates available for further testing, all were identified as E. lenta by both commercially available matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) systems, and none were found to harbor a vanA or vanB gene. Of 23 isolates which underwent susceptibility testing, all were susceptible to amoxicillin-clavulanate, cefoxitin, metronidazole, piperacillin-tazobactam, ertapenem, and meropenem, 91% were susceptible to clindamycin, 74% were susceptible to moxifloxacin, and 39% were susceptible to penicillin.

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Section: Discussionmentioning

confidence: 99%

Clinical and Microbiological Characteristics of Eggerthella lenta Bacteremia

et al. 2015

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“…Formerly a Eubacterium species, it has been reclassified under the bacterial genus Actinobacteria in the family Coriobacteriaceae ( 1 , 2 ). Microbiologically, it is catalase positive ( 1 ), indole negative ( 3 ) and occurs singly or in short chains ( 4 ). It derives its name from Arnold Eggerth, who initially described the bacterium in 1935 ( 2 , 4 ).…”

Section: Discussionmentioning

confidence: 99%

Bacteremia Caused by Eggerthella lenta in an Elderly Man with a Gastrointestinal Malignancy: A Case Report

Wong

Aoki

Rubinstein

2014

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Eggerthella lenta is normally found in the digestive tract, but can cause systemic infections in patients with disrupted mucosal lining due to gastrointestinal diseases or in patients with a compromised immune system. This article describes an 86-year-old man with a systemic E lenta infection that was eventually traced to a gastrointestinal cancer. The authors highlight the high mortality rate associated with this infection and the importance of determining the source of the infection.

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“…They have been associated with ulcerative colitis, Crohn's disease, Hepatobiliary diseases, abscesses, systemic bacteremia, malignancies, decubitus ulcers, diverticular abscess, appendicitis, pancreatic abscess, and pelvic inflammatory disease [5–8]. Eggerthella lenta is named for Arnold Eggerth, who first described the organism in 1935 [9, 10]. The genus Eggerthella was given to these bacteria in 1999 based on 16S rRNA sequence.…”

Section: Discussionmentioning

confidence: 99%

Disseminated Infection Caused byEggerthella lentain a Previously Healthy Young Man: A Case Report

Salameh

Klotz

Zangeneh

2012

Case Reports in Infectious Diseases

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Anaerobic bacteria are the predominant normal flora of the mucous membranes which may cause life-threatening disseminated infections and are often difficult to culture from infected sites. Eggerthella (previously known as Eubacteria species) is an anaerobic, nonsporulating, nonmotile, Gram-positive rod that is found in the human colon and feces and has been isolated from various other clinical specimens. We report a case of complicated disseminated anaerobic bacterial infection with Eggerthella lenta in a healthy immunocompetent man causing multiple brain abscesses, liver abscesses, necrotizing pneumonia, and osteomyelitis of the left radial bone. He was successfully treated with empiric penicillin G and metronidazole.

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Multiple Pyogenic Liver Abscesses Caused byEggerthella lentaTreated with Ertapenem: A Case Report

Cited by 11 publications

References 9 publications

Clinical and Microbiological Characteristics of Eggerthella lenta Bacteremia

Clinical and Microbiological Characteristics of Eggerthella lenta Bacteremia

Bacteremia Caused by Eggerthella lenta in an Elderly Man with a Gastrointestinal Malignancy: A Case Report

Disseminated Infection Caused byEggerthella lentain a Previously Healthy Young Man: A Case Report

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