Disseminated Infection Caused by<i>Eggerthella lenta</i>in a Previously Healthy Young Man: A Case Report

Salameh, Ahmad; Klotz, Stephen A.; Zangeneh, Tirdad T.

doi:10.1155/2012/517637

Cited by 13 publications

(13 citation statements)

References 11 publications

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“…There were many studies published all over the world which describes this rare but potentially lethal complication in children with chickenpox [1,6,8,11,12]. In our case in addition of GAS we noticed also presence of Eggerthella lenta wich may cause life-threatening disseminated infections with initial source from various site including soft tissue (like in our case) [13,14]. Association of these two germs, which may have each separate, aggressive life-threatening evolution, can explain the rapid evolution of the disease in this case.…”

Section: Discussionsupporting

confidence: 59%

Necrotizing fasciitis with group A Streptococci and Eggerthella lenta as a complication of Varicella in a child – case presentation –

Crimi

Margareta²,

Sorina³

et al. 2014

ARS Medica Tomitana

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Necrotizing fasciitis is a life threatening condition that can be quickly spread through the flesh surrounding the muscle. The disease can be polymicrobial, or caused by group A beta hemolytic Streptococci, or by Clostridium spp. We present a case of a 7 years old girl, which was hospitalized in Children Infectious Diseases Department in a 7th day of chickenpox (hematic crusts all over the body), high fever, asthenia, vomiting, oligoanuria, and tumefaction, pain and functio lessa in the right thigh. In a very short time in the right thigh swelling, edema and congestion have increased gradually, and in the third highest middle thigh the ecchymotic areas appeared evolving towards bubbles and blisters which included the right thigh and calf. After excluding the diagnosis of thrombophlebitis was raised suspicion of necrotizing fasciitis. CT pelvic scan evidenced pelvic asymmetry by maximus and medium right gluteal muscles swelling with important inflammatory infiltrate extended laterally in the subcutaneous adipose tissue. In blood culture was isolated Eggerthella lenta, and from throat swab was isolated group A Streptococci. Treatment consists of a combination of antibiotics associated with intravenous immunoglobulin administration. Despite medical treatment evolution worsened and required transfer in a pediatric surgery department where emergent surgical debridement associated with intensive antibiotic therapy was done. After this intervention evolution was slowly favorable without major limb dysfunction. Polymicrobial necrotizing fasciitis is a severe disease, which if recognized early can have a favorable outcome.

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Section: Discussionsupporting

confidence: 59%

Necrotizing fasciitis with group A Streptococci and Eggerthella lenta as a complication of Varicella in a child – case presentation –

Crimi

Margareta²,

Sorina³

et al. 2014

ARS Medica Tomitana

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“…In addition to these series, there are 6 published case reports of patients with E. lenta bacteremia. Two describe severe, disseminated disease with multifocal abscesses requiring extended courses of intravenous antibiotics and/or surgical drainage to cure (12,38). There are other published cases of severe E. lenta infection without definite bacteremia, including reports of frontal sinusitis (43), pyomyositis (44), cutaneous abscesses (45), spondylodiscitis (46), and liver abscess (47).…”

Section: Discussionmentioning

confidence: 99%

Clinical and Microbiological Characteristics of Eggerthella lenta Bacteremia

et al. 2015

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e Eggerthella lenta is an emerging pathogen that has been underrecognized due to historical difficulties with phenotypic identification. Until now, its pathogenicity, antimicrobial susceptibility profile, and optimal treatment have been poorly characterized. In this article, we report the largest cohort of patients with E. lenta bacteremia to date and describe in detail their clinical features, microbiologic characteristics, treatment, and outcomes. We identified 33 patients; the median age was 68 years, and there was no gender predominance. Twenty-seven patients (82%) had serious intra-abdominal pathology, often requiring a medical procedure. Of those who received antibiotics (28/33, 85%), the median duration of treatment was 21.5 days. Mortality from all causes was 6% at 7 days, 12% at 30 days, and 33% at 1 year. Of 26 isolates available for further testing, all were identified as E. lenta by both commercially available matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) systems, and none were found to harbor a vanA or vanB gene. Of 23 isolates which underwent susceptibility testing, all were susceptible to amoxicillin-clavulanate, cefoxitin, metronidazole, piperacillin-tazobactam, ertapenem, and meropenem, 91% were susceptible to clindamycin, 74% were susceptible to moxifloxacin, and 39% were susceptible to penicillin.

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“…E lenta is an anaerobic, nonsporulating, nonmotile, Gram-positive bacillus commonly found in the flora of the healthy human digestive tract ( 1 , 2 ). Formerly a Eubacterium species, it has been reclassified under the bacterial genus Actinobacteria in the family Coriobacteriaceae ( 1 , 2 ). Microbiologically, it is catalase positive ( 1 ), indole negative ( 3 ) and occurs singly or in short chains ( 4 ).…”

Section: Discussionmentioning

confidence: 99%

Bacteremia Caused by Eggerthella lenta in an Elderly Man with a Gastrointestinal Malignancy: A Case Report

Wong

Aoki

Rubinstein

2014

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Eggerthella lenta is normally found in the digestive tract, but can cause systemic infections in patients with disrupted mucosal lining due to gastrointestinal diseases or in patients with a compromised immune system. This article describes an 86-year-old man with a systemic E lenta infection that was eventually traced to a gastrointestinal cancer. The authors highlight the high mortality rate associated with this infection and the importance of determining the source of the infection.

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Disseminated Infection Caused byEggerthella lentain a Previously Healthy Young Man: A Case Report

Cited by 13 publications

References 11 publications

Necrotizing fasciitis with group A Streptococci and Eggerthella lenta as a complication of Varicella in a child – case presentation –

Necrotizing fasciitis with group A Streptococci and Eggerthella lenta as a complication of Varicella in a child – case presentation –

Clinical and Microbiological Characteristics of Eggerthella lenta Bacteremia

Bacteremia Caused by Eggerthella lenta in an Elderly Man with a Gastrointestinal Malignancy: A Case Report

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