Bacteremia Caused by <i>Eggerthella lenta</i> in an Elderly Man with a Gastrointestinal Malignancy: A Case Report

Wong, Davie; Aoki, Fred Y.; Rubinstein, Ethan

doi:10.1155/2014/802481

Cited by 22 publications

(11 citation statements)

References 8 publications

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“…enriched in the migraine group have been reported to be correlated with solid tissue inflammation (Elsayed and Zhang, 2004b), infection (Finegold et al, 2005), and bacteremia (Elsayed and Zhang, 2004a). E. lenta and F. plautii can cause bacteremia (Wong et al, 2014) and bloodstream infection (Berger et al, 2018), respectively. R. gnavus, which degrades mucin (Crost et al, FIGURE 1 | Reduced gut microbial diversity in migraineurs.…”

Section: Differences Of the Gut Microbiome Between Two Groupsmentioning

confidence: 99%

Structural and Functional Characterization of the Gut Microbiota in Elderly Women With Migraine

Chen

Wang

et al. 2020

Front. Cell. Infect. Microbiol.

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Migraine is a very common, multifactorial, and recurrent central nervous system disorder that causes throbbing headache, photophobia, phonophobia, nausea, and disability. Migraine occurs more often in females, and its complex physiopathology is not yet fully understood. An increasing number of gastrointestinal disorders have been linked to the occurrence of migraine suggesting that gut microbiota might play a pivotal role in migraine through the gut-brain axis. In the present work, we performed a metagenome-wide association study (MWAS) to determine the relationship between gut microbiota and migraine by analyzing 108 shotgun-sequenced fecal samples obtained from elderly women who suffer from migraine and matched healthy controls. Notably, the alpha diversity was significantly decreased in the migraine group at species, genus, and Kyoto Encyclopedia of Genes and Genomes (KEGG) orthologous levels. Firmicutes, especially the "unfriendly" Clostridium spp., were significantly enriched in the migraine group. Conversely, the healthy controls held more beneficial microorganisms, such as Faecalibacterium prausnitzii, Bifidobacterium adolescentis, and Methanobrevibacter smithii. For functional modules, the migraine group was enriched in gut-brain modules (GBMs) including kynurenine degradation and γ-aminobutyric acid (GABA) synthesis. However, the healthy controls held higher gut metabolic modules (GMMs) including glycolysis, homoacetogenesis, and GBMs including quinolinic acid degradation and S-adenosyl methionine (SAM) synthesis. The differences in gut microbiota composition and function between the migraine and healthy groups provided new information as well as novel therapeutic targets and strategies for migraine treatment, which could help to improve the early diagnosis of the disease, as well as the long-term prognosis and the life quality of patients suffering from migraine.

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Section: Differences Of the Gut Microbiome Between Two Groupsmentioning

confidence: 99%

Structural and Functional Characterization of the Gut Microbiota in Elderly Women With Migraine

Chen

Wang

et al. 2020

Front. Cell. Infect. Microbiol.

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“…Recent reports have shown that several E. lenta infections were associated with the use of intrauterine devices, spondylodiscitis, female genital tract infections, cutaneous abscesses, and bacteremia (in Crohn's disease patients) [1][2][3][4]12]. These data emphasize the importance of further investigation for bacterial virulence factors.…”

Section: Discussionmentioning

confidence: 86%

“…Predisposing conditions include gastrointestinal tract disease, malignancies, hepatobiliary disease, immobilization, bedsores, diabetes mellitus, and stroke [2][3][4]. E. lenta is an emerging pathogen that has been under-recognized because of difficulties with its laboratory identification [3].…”

Section: Introductionmentioning

confidence: 99%

Bacteremia Caused byEggerthella lentain an Elderly Patient with an Intra-abdominal Abscess

Eom

Kim

et al. 2016

Lab Med Online

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A 73-yr-old male presented with fever, vomiting, and dyspnea.His medical history included a prior cerebrovascular attack and multiple complications caused by hemiplegia, including recurrent urinary tract infections and pressure sores requiring continuous medical care.On the day of admission, his body temperature, pulse rate, respiratory rate, and blood pressure were 40.4°C, 108/min, 39/min, and 170/90 mmHg, respectively. Abdominal examina-tion revealed diffuse tenderness and guarding with absence of bowel sounds. The initial laboratory test data were as follows: Hb, 14.9 g/dL; white blood cell count, 7,250/μL (neutrophils, 78.0%); and platelets, 110,000/μL. His procalcitonin level was elevated to 28.46 ng/mL. Sputum and urine cultures were negative. PCR to detect Eggerthella lenta is an anaerobic, non-spore-forming, non-motile, gram-positive bacillus that can be isolated from human feces and a few other clinical specimens. Bacteremia caused by the organism is rare but, when present, is always of clinical significance. E. lenta is an emerging pathogen that has been under-recognized because of difficulties with its laboratory identification. Few reports on E. lenta infections and the optimal treatment thereof are available. We describe a case of bacteremia caused by E. lenta in an elderly patient with an intra-abdominal abscess. We also review the current literature.

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“…The color bar and the right y-axis indicate the relation between the color of the peak and its intensity, in arbitrary units. Displayed species are indicated on the left pathologies, bacteremia complicated by spondylodiscitis, psoas abscess, and meningitis (Gardiner et al, 2015;Gardiner, Korman, & Junckerstorff, 2014;Wong, Aoki, & Rubinstein, 2014). We herein describe the new genus Raoultibacter gen. nov. within the family Eggerthellaceae using the taxono-genomic approach (Fournier & Drancourt, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…This family contains the type genus Eggerthella and the genera Adlercreutzia , Asaccharobacter , Cryptobacterium , Denitrobacterium , Enterorhabdus , Gordonibacter , Paraeggerthella , Enteroscipio , Rubneribacter , and Slackia (Gupta et al, ). Among its members, Eggerthella lenta is commonly detected in humans and has been associated with bacteremia in patients with intraabdominal or gastrointestinal tract pathologies, bacteremia complicated by spondylodiscitis, psoas abscess, and meningitis (Gardiner et al, ; Gardiner, Korman, & Junckerstorff, ; Wong, Aoki, & Rubinstein, ). We herein describe the new genus Raoultibacter gen. nov. within the family Eggerthellaceae using the taxono‐genomic approach (Fournier & Drancourt, ).…”

Section: Introductionmentioning

confidence: 99%

Noncontiguous finished genome sequence and description of Raoultibacter massiliensis gen. nov., sp. nov. and Raoultibacter timonensis sp. nov, two new bacterial species isolated from the human gut

et al. 2019

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As part of the culturomics project aiming at describing the human microbiota, we report in this study the description of the new bacterial genus Raoultibacter gen. nov. that includes two new species, that is , R. massiliensis sp. nov. and R. timonensis sp. nov. The R. massiliensis type strain Marseille‐P2849 T was isolated from the fecal specimen of a healthy 19‐year‐old Saudi Bedouin, while R. timonensis type strain Marseille‐P3277 T was isolated from the feces of an 11‐year‐old pygmy female living in Congo. Strain Marseille‐P2849 T exhibited 91.4% 16S rRNA sequence similarity with Gordonibacter urolithinfaciens , its phylogenetic closest neighbor with standing in nomenclature. As well, strain Marseille‐P3277 T exhibited 97.96% 16S rRNA similarity with strain Marseille‐P2849 T . Both strains were Gram‐positive, motile, nonspore‐forming rod and form transparent microcolonies on blood agar in both anaerobic and microaerophilic atmospheres. The genome sizes of strain Marseille‐P2849 T and strain Marseille‐P3277 T were 3,657,161 bp and 4,000,215 bp, respectively. Using a taxono‐genomic approach combining the phenotypic, biochemical, and genomic characteristics, we propose the genus Raoultibacter gen. nov., which contains strains Marseille‐P2849 T (= CSUR P2849 T , = DSM 103407 T ) and Marseille‐P3277 T (=CCUG 70680 T , =CSUR P3277 T ) as type strains of the species R. massiliensis sp. nov., and R. timonensis sp. nov., respectively.

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Bacteremia Caused by Eggerthella lenta in an Elderly Man with a Gastrointestinal Malignancy: A Case Report

Cited by 22 publications

References 8 publications

Structural and Functional Characterization of the Gut Microbiota in Elderly Women With Migraine

Structural and Functional Characterization of the Gut Microbiota in Elderly Women With Migraine

Bacteremia Caused byEggerthella lentain an Elderly Patient with an Intra-abdominal Abscess

Noncontiguous finished genome sequence and description of Raoultibacter massiliensis gen. nov., sp. nov. and Raoultibacter timonensis sp. nov, two new bacterial species isolated from the human gut

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