Multiple primary neoplasms and hepatitis C virus infection in oral cancer patients

Yoshida, Mitsuhiko

doi:10.1016/s1386-6346(97)00073-9

Cited by 11 publications

(10 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A review of the literature suggests a possible association between hepatitis C and the development of oral SCC (7–9). Recently, Nobles et al.…”

Section: Discussionmentioning

confidence: 99%

“…The results of a large national case-control study in Japan have also supported the possible association between HCV infection and head and neck squamous cell carcinoma (SCC). It has been suggested that HCV infection may be a cofactor in the development of oral SCC (8) and anti-HCV-positive patients with oral cancer should be considered at high risk for the development of multiple primary neoplasms and should be closely monitored (9). HCV replication has been reported in the oral cancer tissue only in subjects with HCV-RNA-positive serum (10).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

No evidence of hepatitis C virus infection in Serbian patients with oral leukoplakia

Bokor-Bratic

2006

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

“…A review of the literature suggests a possible association between hepatitis C and the development of oral SCC (7–9). Recently, Nobles et al.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

No evidence of hepatitis C virus infection in Serbian patients with oral leukoplakia

Bokor-Bratic

2006

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

“…It has also been demonstrated that oral cancer patients often have carcinoma of the stomach (18%) and liver cancer (16%) as double cancers. Double-cancer patients have significantly higher HCV infection rates than controls (44). In the present case, the patient developed malignant transformation of leukoplakia after testing negative for HCV RNA during Peg-IFN plus RBV therapy.…”

Section: Discussionmentioning

confidence: 54%

Graves' ophthalmopathy and tongue cancer complicated by peg-interferon α-2b and ribavirin therapy for chronic hepatitis C: A case report and review of the literature

Nagao

Hiromatsu²,

Nakashima³

et al. 2008

Mol Med Rep

View full text Add to dashboard Cite

Abstract. Hepatitis C virus (HCV) infection induces not only chronic liver disease, but also extrahepatic manifestations such as thyroid disease and oral cancer. Thyroid dysfunction is also a complication known to be associated with interferon (IFN) therapy for HCV infection. We report on a 69-year-old Japanese man who developed Graves' ophthalmopathy and tongue cancer (malignant transformation of leukoplakia) while receiving peg-interferon (Peg-IFN) α-2b and ribavirin (RBV) treatment for chronic hepatitis C. This patient had no history of thyroid disease before the combination therapy, but did have bilateral leukoplakia of the tongue. The leukoplakia lesions did not change until 20 weeks after the start of the combination therapy, and ophthalmopathy was not diagnosed until 47 weeks later. As ophthalmopathy is considered to be a severe adverse event induced by Peg-IFN α-2b plus RBV, therapy was discontinued after 47 weeks. The patient received a partial glossectomy to remove the malignant neoplasm as well as extraocular muscle surgery for the ophthalmopathy, and was treated with an antithyroid agent and steroids. In conclusion, it is necessary to clinically examine organs other than the liver in patients with HCV infection.

show abstract

“…It is also known that oral cancer patients often have carcinoma of the stomach (18%) and hepatic cancer (16%) as double cancers, and double‐cancer patients have significantly higher HCV infection rates than controls 138 . These findings suggest that HCV plays a role in the development of oral cancer and that HCV carriers need to be aware of the high occurrence of cancers.…”

Section: Malignant Transformation Of Oral Lichen Planusmentioning

confidence: 99%

Hepatitis C virus and lichen planus

Nagao¹,

Sata²

2004

J of Gastro and Hepatol

View full text Add to dashboard Cite

Hepatitis C virus (HCV) is an important factor in the development of chronic liver disease and hepatocellular carcinoma. In recent years it has become known that HCV induces various extrahepatic manifestations including mixed cryoglobulinemia, membranoproliferative glomerulonephritis, Sjögren's syndrome, autoimmune thyroiditis, malignant lymphoma, porphyria cutanea tarda and lichen planus. Although the mechanisms of extrahepatic manifestations remain unclear, it is known that interferon (IFN) therapy and coadministration of IFN with ribavirin are effective in promoting the disappearance or alleviation of such extrahepatic lesions, which have tended to be overlooked. The present review focuses on lichen planus, one of the major extrahepatic manifestations.

show abstract

Multiple primary neoplasms and hepatitis C virus infection in oral cancer patients

Cited by 11 publications

References 15 publications

No evidence of hepatitis C virus infection in Serbian patients with oral leukoplakia

No evidence of hepatitis C virus infection in Serbian patients with oral leukoplakia

Graves' ophthalmopathy and tongue cancer complicated by peg-interferon α-2b and ribavirin therapy for chronic hepatitis C: A case report and review of the literature

Hepatitis C virus and lichen planus

Contact Info

Product

Resources

About