Hepatitis C virus and lichen planus

Nagao, Yumiko; Sata, Michio

doi:10.1046/j.1440-1746.2003.03324.x

Cited by 52 publications

(41 citation statements)

References 160 publications

(189 reference statements)

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“…In particular, T-cells play a major role in this context [2]. While most eruptions of lichen planus are considered to be idiopathic [1], some seem to be linked to hepatitis C [3] or to be drug-induced [4,5]. The number of possibly offending agents is quite high, but the most common drugs include gold, antimalarial agents, penicillin, diuretics, beta-blockers, nonsteroidal anti-inflammatory drugs, quinidine and angiotensinconverting enzyme inhibitors [4,5].…”

Section: Discussionmentioning

confidence: 99%

Generalized Lichen Ruber Planus – Induced by Radiotherapy of the Breast?

Eichbaum¹,

Harms²,

Bolz

et al. 2006

Oncol Res Treat

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Lichen ruber planus is an inflammatory, pruritic disease of the skin and mucous membranes, which can be either generalized or localized. The etiology is unknown. Patients and Methods: A 56-year-old female was treated with standard local radiotherapy after breast-conserving surgery due to high-grade ductal carcinoma in situ (DCIS) of the breast. Results: During radiotherapy, the patient began to complain about increasing disseminated itching papules of the breast. The efflorescences appeared as flat-topped, solid, purplish papules spreading to the limbs and trunk. A thorough clinical examination revealed additionally suspicious cob-web like and white-coated mucosal lesions of the oral cavity consistent with the clinical diagnosis of a generalized lichen ruber planus with an oral manifestation. Conclusion: To our knowledge, this is the first report of a generalized manifestation of lichen ruber planus presumably induced by radiation therapy.

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Section: Discussionmentioning

confidence: 99%

Generalized Lichen Ruber Planus – Induced by Radiotherapy of the Breast?

Eichbaum¹,

Harms²,

Bolz

et al. 2006

Oncol Res Treat

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“…Some studies, however, contest this association (Garg, Karki, Agrawal, & Gupta, 2002;Daramola, George, & Ogunbiyi, 2002;Nagao & Sata, 2004;Patil, Khandelwal, Rahman, Kaswan, & Tipu, 2012). Patil et al (2012) analyzed 130 patients with clinical and histopathological confirmation of OLP with regard to serologic evidence of chronic liver disease.…”

Section: Discussionmentioning

confidence: 99%

“…The authors concluded that there was no evidence of association between OLP and infection by hepatitis B or C virus. According to Nagao and Sata (2004), the prevalence of HCV in patients with LP varies from region to region since it depends on the virulence of the HCV in the country, with no consistent relationship between the two diseases.…”

Section: Discussionmentioning

confidence: 99%

<b>Association between oral lichen planus and hepatitis C: retrospective study and case report

Silva

Jacomacci

Borges

et al. 2017

Acta Sci. Health Sci.

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ABSTRACT. Oral Lichen Planus (OLP), a chronic inflammatory disease of unknown etiology, which affects the skin and/or mucosal tissues, is an autoimmune disease (pathology) of special interest to dentists due to its oral manifestations and its possible association with Hepatitis C virus (HCV). Although a possible association has been extensively discussed in the literature, the results have been controversial. So that the relationship between Oral Lichen Planus (OLP) and infection by HCV (OLP-HCV) may be investigated, current study conducted an epidemiological survey of all OLP cases diagnosed in two reference projects, with regard to diagnosis, treatment and epidemiology of oral lesions in Maringá, Paraná, Brazil. In addition, the clinical case of a patient with HCV and the clinical manifestation of severe OLP will be provided. A total of 3,488 clinical records of biopsies performed between 1994 and 2014 and 85 cases of OLP were selected for the present study. The reticular type of OLP showed significant prevalence but only 2.3% of OLP cases revealed any association with HCV.Palavras-chave: líquen plano, hepatite C, epidemiologia.Associação entre líquen plano oral e hepatite C: estudo retrospectivo e relato de caso RESUMO. Líquen Plano (LP) é uma doença inflamatória crônica de etiologia desconhecida, que acomete pele e/ou mucosas. Esta doença autoimune é de especial interesse para o cirurgião-dentista pelo fato de apresentar manifestações bucais e pode estar associado ao vírus da hepatite C (VHC). Esta possível associação tem sido muito discutida na literatura, apresentando resultados controversos. Com o intuito de investigar a relação entre o Líquen Plano Oral (LPO) e a infecção pelo VHC (LPO-VHC), o presente trabalho objetivou conduzir um levantamento de todos os casos de LPO diagnosticados em dois projetos de referência quanto a diagnóstico, tratamento e epidemiologia de lesões bucais na cidade de Maringá, Paraná, Brasil. Adicionalmente, um caso clínico de um paciente portador do VHC com manifestação clínica severa de líquen plano será apresentado. Foram selecionados para o presente estudo um total de 3.488 prontuários de biópsias realizadas entre os anos de 1994 e 2014 e 85 casos de LPO. O LPO do tipo reticular apresentou prevalência estatisticamente significante e apenas 2.3% dos casos de LPO apresentaram associação com o VHC.

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“…Nagao and Sata 28 found out that the relation between LP and Hepatitis C is not consistent; and that the prevalence of this virus in association with the disease varies from 0-60% in scientific publications, depending on in which country the research was carried out, what may be attributed to different prevalences of the virus within the general population.…”

Section: Discussionmentioning

confidence: 99%

Avaliação clínica das lesões orais associadas a doenças dermatológicas

Gonçalves

Júnior²,

Cruz

2010

An. Bras. Dermatol.

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BACKGROUND: Dermatologic diseases are not only represented by lesions affecting the skin but also by manifestations that may involve the mucous membranes, including oral mucosa. OBJECTIVES: To evaluate the frequency of oral manifestations associated with dermatologic diseases considering location and clinical characteristics of the lesions found and also gender, age and race of patients. METHOD: It was an observational, cross-sectional study of patients who sought for treatment at the Dermatology Service of the University Hospital (Hospital Presidente Dutra-HUPD); UFMA, between October 2007 and October 2008 (n=88) . RESULTS: Age varied from 5 to 88 and there was predominance of female patients. 35% of the cases studied were diagnosed as lichen planus; 33% as lupus erythematosus; 24% as erythema multiforme; 7% as pemphigus vulgaris and 1% as pemphigoid group. Oral manifestations were more common among patients suffering from lichen pplanus (51%) and lupus erythematosus (20%). The most common clinical presentation found was reticular lichen planus located most predominantly in the buccal mucosa. CONCLUSIONS: It is essential that dentists know these pathologies to be able to diagnose them in an early stage of the disease and to direct patients to adequate treatment. Furthermore, intraoral examination should be included as a routine practice in dermatological services. Keywords: Dermatology; Diagnosis, oral; Oral manifestations Resumo: FUNDAMENTOS: As doenças dermatológicas não estão representadas apenas pelas lesões que afetam a pele, mas, também, por manifestações que podem envolver as mucosas, inclusive a mucosa oral. OBJETIVOS: Avaliar a frequência das manifestações orais em pacientes com doenças dermatológicas, considerando-se a localização e as características clínicas das lesões encontradas, o sexo, a idade e a raça dos acometidos. MÉTODOS: Estudo observacional, do tipo transversal, com pacientes que procuraram atendimento no Serviço de Dermatologia do Hospital Universitário Presidente Dutra (HUPD) da Universidade Federal do Maranhão (UFMA) entre outubro de 2007 e outubro de 2008 (n=88). RESULTADOS: A idade variou entre cinco e 88 anos, e o sexo feminino foi o mais atingido (2:1). Dos casos examinados, 35% eram de líquen plano, 33% de lúpus eritematoso, 24% de eritema multiforme, 7% de pênfi-go vulgar e 1% do grupo penfigoide. As lesões orais foram mais frequentes nos portadores de líquen plano (51%) e lúpus eritematoso (20%). O líquen plano reticular foi a forma clínica mais comum e a mucosa jugal, o sítio mais acometido. CONCLUSÕES: O conhecimento dessas patologias pelo cirurgião-dentista é de fundamental importância, cabendo-lhe uma parcela de responsabilidade pelo diagnóstico precoce e orientação para o tratamento adequado. Além disso, o exame intraoral deve ser incorporado como prática de rotina durante o atendimento dermatológico.

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Hepatitis C virus and lichen planus

Cited by 52 publications

References 160 publications

Generalized Lichen Ruber Planus – Induced by Radiotherapy of the Breast?

Generalized Lichen Ruber Planus – Induced by Radiotherapy of the Breast?

<b>Association between oral lichen planus and hepatitis C: retrospective study and case report

Avaliação clínica das lesões orais associadas a doenças dermatológicas

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