No evidence of hepatitis C virus infection in Serbian patients with oral leukoplakia

Bokor-Bratic, Marija

doi:10.1111/j.1600-0714.2006.00479.x

Cited by 4 publications

(4 citation statements)

References 19 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, the prevalence of leukoplakia in our study seems to reflect the oral habits of tobacco consumption in the studied group and possibly does not represent a real association with hepatitis C infection. This observation is in accordance with research from Bokor‐Bratic (42) on Serbian patients.…”

Section: Discussionsupporting

confidence: 93%

Oral Mucosal Conditions in Chronic Hepatitis C Brazilian Patients: A Cross‐Sectional Study

Grossmann

Teixeira

Aguiar

et al. 2009

J Public Health Dent

View full text Add to dashboard Cite

The prevalence of patients with chronic hepatitis C presenting oral mucosal conditions was 96.3 percent. Despite this high prevalence, only the association between oral lichen planus and hepatitis C showed statistical significance. Considering that HCV infection may be associated with extrahepatic disorders, such as oral manifestations, efforts should be made to clarify the possible relation between oral conditions and HCV infection. This may be helpful in the earlier diagnosis of the infection mainly in asymptomatic patients.

show abstract

Section: Discussionsupporting

confidence: 93%

Oral Mucosal Conditions in Chronic Hepatitis C Brazilian Patients: A Cross‐Sectional Study

Grossmann

Teixeira

Aguiar

et al. 2009

J Public Health Dent

View full text Add to dashboard Cite

show abstract

“…Their finding suggests that HBV infection is unlikely to play a major role in oral tumor formation. A study by Bokor-Bratic also suggested that oral leukoplakia was not associated with HBV infection in Serbia [37]. In addition, only HCV has the lymphatrophic character that is assumed to be the cause of HCV-associated extrahepatic manifestations [38].…”

Section: Discussionmentioning

confidence: 98%

Positive Association Between Hepatitis C Infection and Oral Cavity Cancer: A Nationwide Population-Based Cohort Study in Taiwan

Chang

Chen

et al. 2012

PLoS ONE

View full text Add to dashboard Cite

ObjectivesThe association between viral hepatitis (B and C) and oral cavity cancer has been widely debated. This nationwide, population-based cohort study assessed the subsequent risk of oral cavity cancer among patients with chronic viral hepatitis infection.Materials and MethodsData were retrieved from insurance claims data of 1,000,000 randomly sampled individuals covered under the Taiwan National Health Insurance system. We identified a total of 21,199 adults with chronic viral hepatitis infection (12,369 with HBV alone, 5,311 with HCV alone, and 3,519 with HBV/HCV dual infections) from 2000–2005. Comparison group comprised 84,796 sex- and age-matched subjects without viral hepatitis during the same study period. Incidence and risk of subsequent oral cavity cancer were measured until 2008.ResultsThe incidence of oral cavity cancers was 2.28-fold higher among patients with HCV alone than non-viral hepatitis group (6.15 versus 2.69 per 10,000 person-years). After adjusting for sociodemographic covariates, HCV alone was significantly associated with an increased risk for oral cavity cancer (hazard ratio (HR) = 1.90, 95% confidence interval (CI) = 1.20–3.02). This positive association was highest among individuals in the 40–49-year age group (HR = 2.57, 95% CI = 1.21–5.46). However, there were no significant associations between HBV alone or HBV/HCV dual infections and risk for oral cavity cancer.ConclusionOur data suggest that HCV but not HBV infection is a risk factor for oral cavity cancer. In addition, subjects with HCV infection tend to be at early onset risk for oral cavity cancer. This finding needs to be replicated in further studies.

show abstract

“…However, HCV is a common cause of liver cirrhosis which may represent itself an independent risk factor for the development of oral cancer (Sorensen et al , 1998). On the other hand, potentially oral premalignant lesions such as leukoplakia and oral epithelial dysplasia are not associated with HCV infection (Carrozzo et al , 1996; Jaber et al , 2003; Bokor‐Bratic,2006).…”

Section: Oral Carcinomamentioning

confidence: 99%

Oral diseases associated with hepatitis C virus infection. Part 2: lichen planus and other diseases

Carrozzo

2008

Oral Diseases

View full text Add to dashboard Cite

Some of the most frequent extrahepatic manifestations of hepatitis C virus (HCV) infection involve the oral region predominantly or exclusively. Part 2 of this review discusses the current evidences regarding the association of lichen planus (LP) and other diseases frequently involving the oral cavity with HCV. Epidemiological data suggest that LP may be significantly associated with HCV infections especially in southern Europe and Japan but not in northern Europe. These geographical differences are possibly influenced by immunogenetic factors, the duration of the HCV infection and the design of the published studies. Because of the fact that most of the studies published are retrospective, it is impossible to establish whether the HCV exposure occurred earlier to or after the onset of disease and more prospective studies are clearly warranted. As the virus may replicate in the skin and oral mucosa and HCV-specific T lymphocytes can be found in the oral mucosa of patients with chronic hepatitis C and LP, HCV may be implicated in the pathogenesis of LP. However, little attention has been paid to the variable effect of therapy with interferon-alpha (IFN-alpha), with or without ribavirin for LP. Conversely, it is unlikely that other oral diseases such as oral carcinoma, pemphigus and Behcet disease are triggered by HCV.

show abstract

No evidence of hepatitis C virus infection in Serbian patients with oral leukoplakia

Abstract: The present data indicate that patients with OL resident in Serbia do not have evidence of HCV or HBV infection.

Cited by 4 publications

References 19 publications

Oral Mucosal Conditions in Chronic Hepatitis C Brazilian Patients: A Cross‐Sectional Study

Oral Mucosal Conditions in Chronic Hepatitis C Brazilian Patients: A Cross‐Sectional Study

Positive Association Between Hepatitis C Infection and Oral Cavity Cancer: A Nationwide Population-Based Cohort Study in Taiwan

Oral diseases associated with hepatitis C virus infection. Part 2: lichen planus and other diseases

Contact Info

Product

Resources

About