Multiple, Primary Brain Tumors with Diverse Origins and Different Localizations: Case Series and Review of the Literature

Tunthanathip, Thara; Kanjanapradit, Kanet; Ratanalert, Sanguansin; Phuenpathom, Nakornchai; Oearsakul, Thakul; Kaewborisutsakul, Anukoon

doi:10.4103/jnrp.jnrp_82_18

Cited by 22 publications

(16 citation statements)

References 41 publications

(48 reference statements)

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“…Females are more affected and surgical removal remains the major intervention and the prognosis is poor [41]. Side of head of interventional cardiologists/radiologists is more vulnerable to brain tumours [42].…”

Section: Discussionmentioning

confidence: 99%

Comparative Parameters of Occult and Multiple Brain Tumors In Human: The Implication for Therapy

Saganuwan

2021

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Background Brain cancer treatment is a difficult task, because of complex nature of physico-chemical properties of brain, central nervous system (cns) acting drugs and drug carriers. Methods In view of this, literatures were searched with a view to assessing comparative mathematical parameters of occult and multiple primary brain tumors and their therapeutic outcomes. A total of thirteen patients comprised of eight males and five females who had suffered either occult or multiple brain tumors were used for the study. Tumor parameters and their therapeutic prognoses were mathematically determined. The data were analyzed using a modified Kaplan-Meier method at 5 % level of significance. Results Findings have shown that occult tumors such as meningiosarcoma (65.4cm3), teratoma (268 cm3), solitary brain tumor (20.6–22.4 cm3) and gliosarcoma (31.1 cm3) as well as multiple primary brain tumors; meningioma/diffuse astrocytoma (47.7 cm3), glioblastoma multiforme/pituitary adenoma (164. 59 cm3) and planum sphenoidale meningioma/pituitary adenoma (26.52 cm3) are deadly. However solitary brain tumor (4.2 cm3), glioblastoma multiforme/pituitary adenoma (12.77 cm3) and multimeningioma/pituitary adenoma (0.70 cm3) have high survival rate. Generally tumor weight (4.2–144.0 g), tumor density (0.24–0.96), total population of tumor cells (9.5 x 108-2.5 x 1011, rate of tumor cell migration (1.10–48.0 cm2/yr) and tumor radius (0.55-4.0 cm) are relatively moderate to very high, signifying that occult brain tumors may generate faster and may be more difficult to treat chemotherapeutically, radiotherapeutically, immunologically and surgically. Brain tumors affect male and female of 2–79 years old. Conclusions The locations of tumors are parietal, temporal, frontal, thalamic, frontoparietal, stellar, and planum sphenoidale lobes. Both occult and multiple brain tumors are diagnosed when all forms of therapy would have been useless.

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Section: Discussionmentioning

confidence: 99%

Comparative Parameters of Occult and Multiple Brain Tumors In Human: The Implication for Therapy

Saganuwan

2021

Preprint

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“…[ 27 ] Some authors have reported co-existence of multiple, primary brain tumors wherein GBM was seen in association with pituitary adenoma. [ 28 ] Since not much literature is available regarding the etiology of GBM as a SPM, its occurrence by chance cannot be entirely ruled out.…”

Section: Discussionmentioning

confidence: 99%

Glioblastoma occurring as second primary in a treated case of diffuse large B-Cell lymphoma

et al. 2021

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Glioblastoma as second primary malignancy (SPM) has been reported after prostate cancer, meningiomas, Hodgkin's lymphoma. We report an extremely rare case of glioblastoma as SPM, occurring after remission of diffuse large B-cell lymphoma (DLBCL). Fifty-year-old male presented with loss of consciousness followed by right-sided weakness. He was treated with chemotherapy for DLBCL of the cervical lymph nodes, 5 years back. Present scans revealed well-defined intra-axial lesion in the left parietal lobe, suggestive of central nervous system (CNS) involvement by lymphoma. Left parieto-occipital craniotomy was performed and microscopic examination revealed the tumor to be Glioblastoma, WHO Grade IV. The tumor cells were positive for glial fibrillary acid protein and negative for leucocyte common antigen. He was treated by radiotherapy and temozolomide. Pathologic examination is a must for CNS lesions. Had it not been for the biopsy, the patient would have been treated as a recurrence of CNS lymphoma by chemotherapy and would have probably succumbed.

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“…One of them had uterine broid and osteoma on the left tibia, while the other four had uterine broid, renal clear cell carcinoma, thyroid carcinoma, and glioblastoma, respectively. Multiple primary brain tumors with different histological types occurring in the same patient are extremely rare, and only a few such cases have been reported thus far [14,15]. Tunthanathip reported 6 cases of simultaneous multiple, primary brain tumors, predominantly in aging patients.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Short-Term Surgery Outcomes Between Older and Younger Patients With Middle Third Parasagittal and Falx Meningioma

Lin

Chen

Liu

et al. 2021

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Background and Purpose Middle third parasagittal and falx meningiomas can cause severe neurological deficits. The incidence of meningioma rises with age and comorbidities. Elderly patients may suffer from operative complications and recover more slowly than younger patients. The aim of this study was to assess the clinical characteristics and surgery outcomes between younger and elderly patients with meningiomas. Methods The patients of middle third parasagittal and falcine meningiomas operated from January 2011 and December 2019 were reviewed in this retrospective study. All lesions arose from the middle third of the falx or superior sagittal sinus (SSS). The complications, such as peritumoral edema, operative blood loss, and neurological deficit, and postoperative hospital stay, were compared between groups. Results Forty-three elderly patients and 63 younger patients were included in the current study. The elderly had larger and more aggressive lesions than younger individuals (P=0.013). Moreover, the aging group had severe peritumoral edema (P=0.019) and longer postoperative hospital stay (P=0.009) than younger patients, while the younger suffered from higher blood loss (P=0.022) and reoperation (3 vs. 1) at perioperative period. Furthermore, no significant difference was detected in the neurological deficit between the two groups (p=0.97). Conclusions Although severe peritumoral edema gave rise to larger lesions, elderly patients with the middle third of parasagittal and falcine meningiomas shared similar surgery outcomes as younger individuals. However, after considering all the factors, elderly patients were more likely to develop minor postoperative complications compared to younger ones.

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Multiple, Primary Brain Tumors with Diverse Origins and Different Localizations: Case Series and Review of the Literature

Cited by 22 publications

References 41 publications

Comparative Parameters of Occult and Multiple Brain Tumors In Human: The Implication for Therapy

Comparative Parameters of Occult and Multiple Brain Tumors In Human: The Implication for Therapy

Glioblastoma occurring as second primary in a treated case of diffuse large B-Cell lymphoma

Comparison of Short-Term Surgery Outcomes Between Older and Younger Patients With Middle Third Parasagittal and Falx Meningioma

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