Multiple polypoid lesions of primary mucosa‐associated lymphoid‐tissue lymphoma of colon

Yatabe, Yasushi; Nakamura, Shigeo; Nakamura, Toshiyasu; Seto, Masao; Ogura, Michinori; Kimura, Miwako; Kuhara, Hajime; Kobayashi, Takahiko; Taniwaki, Masafumi; Morishima, Yasuo; Koshikawa, Takashi; Suchi, Taizan

doi:10.1046/j.1365-2559.1998.00315.x

Cited by 58 publications

(43 citation statements)

References 32 publications

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“…In lymphomas presenting as polyps, usual histology was that of mantle cell lymphoma. 21,22 In our study, Mucosa Associated Lymphoid Tissue (MALT) category was the common type.…”

Section: Histomorphologic Types Of Polypsmentioning

confidence: 69%

Morphological Study of Intestinal Polyps With Clinicopathological Correlation - 2 Years Observational Study at a Tertiary Care Centre of South India

Manakkad¹,

Priyadarshini²,

Bindu³

2016

jemds

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BACKGROUNDPolyps of the intestine are common specimens and do not have symptoms unless they cause obstruction or bleed. 1 There are many types of intestinal polyps. Among all polyps, most frequently occurring are adenomatous polyps. Adenomas are considered precursor lesions to invasive carcinoma. Colorectal cancer stands second to lung cancer as the most common cause of cancer mortality. The basic aim of management of patients with adenomatous polyps in the large bowel remains to prevent the development of cancer by detection and removal of precancerous lesions.The objective of this study is to classify intestinal polyps and identify prevalence of each morphologic type. To study the gross and histopathological features and to correlate with clinical data.

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“…In lymphomas presenting as polyps, usual histology was that of mantle cell lymphoma. 21,22 In our study, Mucosa Associated Lymphoid Tissue (MALT) category was the common type.…”

Section: Histomorphologic Types Of Polypsmentioning

confidence: 69%

Morphological Study of Intestinal Polyps With Clinicopathological Correlation - 2 Years Observational Study at a Tertiary Care Centre of South India

Manakkad¹,

Priyadarshini²,

Bindu³

2016

jemds

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“…46,47 As well, patients with clinical presentation of lymphomatous polyposis occasionally have been reported as having marginal zone lymphomas of MALT type. 48,50 The immunophenotype of the follicular and MALT lymphoma variants of lymphomatous polyposis clearly differs from that of the more common mantle cell cases.…”

Section: -46mentioning

confidence: 99%

Lymphoproliferative Disorders of the Gastrointestinal Tract: A Review and Pragmatic Guide to Diagnosis

Burke

2011

Archives of Pathology &Amp; Laboratory Medicine

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Context.—The gastrointestinal tract is the most common site of extranodal lymphomas. Although all histologic categories of malignant lymphoma develop in the gastrointestinal tract, large B-cell lymphomas predominate, followed by extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT) type; the latter is especially prevalent in stomach. The acceptance of extranodal marginal zone lymphoma of MALT type as a clinicopathologic entity has reduced the number of cases that formerly were interpreted as florid lymphoid hyperplasia (“pseudolymphoma”). Nonetheless, the distinction of lymphoid hyperplasia from a lymphoma of MALT type in small biopsy specimens remains problematic. Objective.—To assess the relevant morphologic, immunologic, molecular, and genetic properties of gastrointestinal lymphomas and to present a feasible tactic for diagnosis, expressly for small biopsy specimens. Data Sources.—Case-derived material and literature review using PubMed (National Library of Medicine). Conclusions.—Most gastrointestinal lymphomas are readily amenable to an unqualified diagnosis, primarily those cases consisting of monomorphic large cells whether of B- or T-cell lineage, including cases associated with enteropathy. Diagnosis for infiltrates dominated by small lymphocytes remains taxing, as the differential diagnosis embraces not only MALT lymphoma and lymphoid hyperplasia but also mantle cell lymphoma, follicular lymphoma, and chronic lymphocytic leukemia/small lymphocytic lymphoma. Adherence to strict morphologic criteria is the standard for diagnosis, but these criteria should be augmented by immunologic studies together with judicious use of molecular techniques to determine clonality. In establishing a diagnosis of gastric marginal zone lymphoma of MALT type, determination of t(11;18)(q21;q21) status may be required since this translocation has clinical ramifications.

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“…Thus, the present case was more consistent with a MALT lymphoma forming MLP rather than IPSID. To our knowledge, only 4 cases of MALT lymphoma forming MLP have been reported [14][15][16] , indicating that our present case is actually rare. In regard to the origin of this lymphoma, we could not completely deny the suspicion that a lymph node might be the origin of the disease because of the swollen mesenteric lymph nodes.…”

Section: Discussionmentioning

confidence: 63%

A case of mucosa-associated lymphoid tissue lymphoma forming multiple lymphomatous polyposis in the small intestine

Hirata

Tominaga²,

Ohta³

et al. 2007

WJG

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A 50-year old woman suffering from diabetes had a CT scan that revealed a diffuse thickening of small intestinal wall and swollen paraaortic lymph nodes. An esophago gastroduodenoscopy (EGD) confirmed multiple polypoid lesions in the duodenum and small intestine, and conventional histological testing revealed non-specific inflammatory changes. Further examinations including the immunohistochemical profiles of the biopsied specimens led us to diagnose the lesion as a marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type, forming multiple lymphomatous polyposis sequentially spreading from duodenal bulb to terminal ileum. According to Lugano's classification, its staging was clinically diagnosed as stage Ⅱ. Two courses of a standard CHOP (cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and predonisolone) regimen with rituximab reduced the lesion and the patient had a almost complete response. A 5-year followup EGD and histological examinations detected no recurrence of the disease.

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Multiple polypoid lesions of primary mucosa‐associated lymphoid‐tissue lymphoma of colon

Abstract: This study has indicated that the multiple polypoid lesions of the colon occur not only in MCL, but also in MALT lymphoma, making differential diagnosis between the two entities necessary, and cyclin D1 immunohistochemistry is indispensable for distinguishing between them.

Cited by 58 publications

References 32 publications

Morphological Study of Intestinal Polyps With Clinicopathological Correlation - 2 Years Observational Study at a Tertiary Care Centre of South India

Morphological Study of Intestinal Polyps With Clinicopathological Correlation - 2 Years Observational Study at a Tertiary Care Centre of South India

Lymphoproliferative Disorders of the Gastrointestinal Tract: A Review and Pragmatic Guide to Diagnosis

A case of mucosa-associated lymphoid tissue lymphoma forming multiple lymphomatous polyposis in the small intestine

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