Multiple Ocular Anomalies Associated With Maternal LSD Ingestion

Dominantly inherited unilateral retinal dysplasia.

“…D-Lysergic diethylamide (LSD) ingestion in the first trimester of pregnancy has also been implicated. 12 Bilateral retinal dysplasia without any other congenital abnormality was reported by Wilson in 1949'3 and Hunter in 1965'4 in a large Ojibway Indian family. The pedigree of this family is consistent with X linked recessive inheritance.…”

Bilateral persistent fetal vasculature: A study of 11 cases

“…5 Although the genes responsible for PFV are unknown, the lack of inheritance suggests that idiopathic, isolated, sporadic mutations may be responsible for the disease-a developmental defect caused by environmental factors during embryogenesis rather than genetic factors. 3 Ocular associations described for unilateral PFV include microphthalmia, megalocornea, Peters anomaly, cataract, colobomas, retinal detachment with retinal dysplasia, 6 intraocular cartilage, 7 and homonymous hemianopia. 8 Important systemic associations include hemiparesis, impaired coordination, ataxia, hypotonia, spastic quadriplegia, microcephaly and deafness, arachnoid cysts, 4 syndactyly, congenital heart anomalies, pulmonary atresia, asplenia, and Aicardi syndrome.…”

Illicit substance use in pregnancy – a review

“…68 Further, LSD has been shown to have oxytocic effects on isolated rat uterine smooth muscle. 69 There are very limited reports of the effect of LSD on human pregnancy, with a number of reported cases of ocular abnormalities, 70 although in a single case series of 10 women known to have taken LSD during pregnancy, there were no adverse pregnancy outcomes or congenital abnormalities noted. 71 Psilocybin is the active ingredient in Psilocybe mushrooms and is a 5HT-2A receptor agonist, which when ingested causes altered perception of the demarcation between self and the surrounding environment, resulting in feelings of 'unifying with a higher reality' and visual hallucinations.…”