Bilateral persistent fetal vasculature: A study of 11 cases

Kumar, Anand; Jethani, Jitendra; Shetty, Shashikant; Vijayalakshmi, P

doi:10.1016/j.jaapos.2010.05.007

Cited by 21 publications

(6 citation statements)

References 17 publications

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“…Bilateral nonperfusion of the peripheral retinal vasculature has been described in pediatric retinal diseases such as retinopathy of prematurity, 4 familial exudative vit-reortinopathy, 5 Norrie disease, 6 and most recently in persistent fetal vasculature. 7,8 However, it is a clinical newly recognized finding described in NAI. 2,3 The link between the biomechanics of NAI to the bilateral peripheral retinal nonperfusion in chronically shaken children is not clearly understood.…”

Section: Report Of Casesmentioning

confidence: 99%

Fluorescein Angiographic and Histopathologic Findings of Bilateral Peripheral Retinal Nonperfusion in Nonaccidental Injury: A Case Series

Bielory¹

2012

Arch Ophthalmol

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Section: Report Of Casesmentioning

confidence: 99%

Fluorescein Angiographic and Histopathologic Findings of Bilateral Peripheral Retinal Nonperfusion in Nonaccidental Injury: A Case Series

Bielory¹

2012

Arch Ophthalmol

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“…Kumar et al reported similar results in addition to a higher incidence of cataract. ey also reported that the PFV in these cases is both anterior and posterior [9]. e association of MGS and PFV has been reported in several cases, and the largest series that described this association was by Fei et al In this case series, 25.88% of patients with MGS were found to have an associated PFV.…”

Section: Discussionmentioning

confidence: 61%

“…Kumar et al reported similar results in addition to a higher incidence of cataract. They also reported that the PFV in these cases is both anterior and posterior [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Bilateral Morning Glory Syndrome with Bilateral Persistent Fetal Vasculature in a Patient with Joubert’s Syndrome

Araissi

Fayed

Helmy

2020

Case Reports in Medicine

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Purpose. We report a case of a 1-year-old girl who was referred to us with a cerebellar anomaly and delayed growth and development for bilateral ptosis and poor fixation. Based on our ophthalmologic examination, we concluded that she has bilateral persistent fetal vasculature (PFV) with morning glory syndrome (MGS). A closer look into her neurologic condition revealed that she has Joubert’s syndrome. Observations. External examination revealed bilateral symmetrical ptosis with syndromic facies and her fundus examination revealed a large dysplastic optic disc with anomalous radiating vessels and a fibrous tissue tuft originating from the disc. The left eye showed similar findings in addition to a central excavation and a fibrovascular stalk extending from the optic disc. These findings were consistent with bilateral MGS and bilateral PFV. The brain imaging included a computed tomography scan and magnetic resonance imaging, both of which revealed a “molar tooth appearance” of the midbrain and an anomalous cerebellum suggestive of Joubert’s syndrome. Conclusions and Importance. This is the first case report of a case of bilateral MGS and bilateral PFV associated with Joubert’s syndrome. This case report documents the associated optic nerve disease in these patients, not previously described, which are additive causes of visual compromise in addition to the brain insult.

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“…However, RV, HSV-I, and II IgM-positivity have been reported earlier in bilateral PFV children in some sporadic studies, as well. [ 33 34 ] Such an occurrence can possibly be explained by the developmental arrest of the lenticulo-vascular system secondary to infection in-utero .…”

Section: Discussionmentioning

confidence: 99%

ToRCH-screening in pediatric cataract revisited: A North Indian tertiary care centre study

Dasgupta¹,

Shakeel²,

Roy³

2020

Indian J Ophthalmol

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Purpose: To analyze and report ToRCH-serology screening profile ( Toxoplasma gondii [TOX], rubella [RV], cytomegalovirus [CMV], and herpes simplex virus [HSV-I/II]) in pediatric cataract. Methods: In this prospective analytical study, 1,026 consecutive children were screened, of which 46 children with clinically diagnosed congenital ( n = 26) and developmental cataract ( n = 20) were included. Post-traumatic and familial cataracts were excluded. Sera of all children were tested both qualitatively and quantitatively for IgG/IgM-antibodies against ToRCH agents in a sequential manner. Results: Overall, IgM/IgG-seropositivity against ≥1 ToRCH agent was reported in 91.3% (42/46) children. IgM (±IgG) positivity against ≥1 ToRCH agent was reported in 26.08% (12/46) children (nine congenital and three developmental cataract; P = 0.18), which included 8.7% (4/46) children reported positive against ≥2 agents. Finally, 13% (6/46) children were reported to be sero-clinical-positive (three were infants and three were >1 year age, P = 0.55; five congenital and one developmental cataract, P = 0.21). Either alone or combined, RV attributed to the majority (50%; 6/12) of the IgM (±IgG) and sero-clinical-positive (50%; 3/6) children. None of the children were HSV-II IgM-positive. Laboratory-confirmed congenital rubella syndrome was reported in 4.3% (2/46) children. One sero-clinical-positive infant with rare coexisting bilateral persistent fetal vasculature was also reported. IgG-alone positivity was reported highest with CMV in 67.4% (31/46) children, whereas 43.4% (20/46) children were found nonimmune to RV. Conclusion: The current study emphasizes the need to interpret ToRCH-screening in pediatric cataract with caution. Interpretation should include both serial qualitative and quantitative assays in tandem with clinical correlation to minimize the diagnostic errors. Clinicians should remain vigilant regarding sero-clinical-positivity in older children too who might pose a threat to the spread of infection.

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Bilateral persistent fetal vasculature: A study of 11 cases

Cited by 21 publications

References 17 publications

Fluorescein Angiographic and Histopathologic Findings of Bilateral Peripheral Retinal Nonperfusion in Nonaccidental Injury: A Case Series

Fluorescein Angiographic and Histopathologic Findings of Bilateral Peripheral Retinal Nonperfusion in Nonaccidental Injury: A Case Series

Bilateral Morning Glory Syndrome with Bilateral Persistent Fetal Vasculature in a Patient with Joubert’s Syndrome

ToRCH-screening in pediatric cataract revisited: A North Indian tertiary care centre study

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