Multiple Neurofibromatosis Involving the Urinary Bladder

Kimbrough, James C.; Furst, John N.; Worgan, D.

doi:10.1093/milmed/102.5.346

Cited by 3 publications

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“…There have been approximately 50 reported cases of neurofibroma of the urinary bladder since 1932 (Table 3). 6–39 The tumors typically occur in young patients with neurofibromatosis type 1. Clinical presentations are similar to those related to posterior urethral valves in male patients.…”

Section: Discussionmentioning

confidence: 99%

Neurofibroma of the urinary bladder

Liu

Scheithauer

Leibovich

et al. 1999

Cancer

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BACKGROUND Neurofibroma of the urinary bladder is rare. Only isolated case reports have appeared. Information regarding the long term follow‐up of patients with neurofibroma is limited. METHODS The authors studied 4 cases of neurofibroma of the bladder diagnosed at Mayo Clinic from 1965 through 1990. Immunostains for S‐100 protein, neurofilament protein, epithelial membrane antigen (EMA), cytokeratin (CAM 5.2; AE 1/3), Type IV collagen, MIB‐1, and p53 protein were performed in all cases, as was Alcian blue at pH 2.5. The mean follow‐up was 9.6 years (range, 2–18 years). RESULTS The mean age at diagnosis was 17 years (range, 7–28 years); the male‐to‐female ratio was 1:1. All four patients exhibited physical stigmata of neurofibromatosis type 1. Clinical presentations included hematuria (one patient), irritative symptoms (two patients), and pelvic mass (one patient). Long term urinary complications included bladder atony (two patients), neurogenic bladder (one patient), and recurrent urinary tract infection with hematuria (one patient). Subsequently, two patients underwent partial cystectomy and one a complete cystectomy. Involvement of the bladder was generalized in all four cases. Three tumors were transmural, showing a diffuse and plexiform pattern of growth; in the fourth case, a superficial biopsy showed only diffuse submucosal growth with conspicuous pseudo‐Meissnerian corpuscle formation. An Alcian blue positive, variably collagenized matrix was present in all cases. Tumor cells displayed immunoreactivity for S‐100 protein and Type IV collagen in all cases. Neurofilament protein positive axons were evident in three cases; all other immunostains were negative. The mean MIB‐1 labeling index was 3.2% (range, 0.9–7.3%). No malignant transformation was observed during a mean follow‐up of 9.6 years. CONCLUSIONS Neurofibroma of the bladder presents early in life, is of the plexiform type with a diffuse component, and usually occurs in the setting of generalized neurofibromatosis type 1 rather than as isolated visceral neurofibromatosis. Malignant transformation did not occur in any of these 4 patients during a mean follow‐up time of 9.6 years. Cancer 1999;86:505–13. © 1999 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

Neurofibroma of the urinary bladder

Liu

Scheithauer

Leibovich

et al. 1999

Cancer

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Urologic manifestations of von Recklinghausen neurofibromatosi

Blum¹,

Bahnson²,

Carter³

1985

Urology

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Neurofibromatosis of the Pelvic Autonomic Plexuses

Pessin¹,

Bodian²

1964

British Journal of Urology

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SUMMARY A review of the literature on cases of neurofibromatosis of the bladder is given. Eighteen cases have been recorded in adults, three of which were confined to the bladder wall, and fifteen, associated with multiple cutaneous lesions. Six cases of neurofibromatosis of the bladder have been recorded in childhood, four of these with generalised involvement and two affecting only the bladder. A further two instances, both with bladder involvement, are reported from The Hospital for Sick Children, Great Ormond Street. One of these has been treated by means of radical surgery. The etiological relationship of these lesions to the pelvic plexuses is discussed.

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Multiple Neurofibromatosis Involving the Urinary Bladder

Cited by 3 publications

References 0 publications

Neurofibroma of the urinary bladder

Neurofibroma of the urinary bladder

Urologic manifestations of von Recklinghausen neurofibromatosi

Neurofibromatosis of the Pelvic Autonomic Plexuses

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