Neurofibromatosis of the Pelvic Autonomic Plexuses

Pessin, James I.; Bodian, M.R.C.P. Martin

doi:10.1111/j.1464-410x.1964.tb09539.x

Cited by 38 publications

(10 citation statements)

References 13 publications

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“…In these cases, bulky soft-tissue masses are so extensive throughout the abdomen that they simulate malignancy (Fig 14). Neurofibromas of the bladder arise from the vesicoprostatic and vesicovaginal neural plexuses that enter the posterolateral aspect of the bladder near the trigone (25). The prostate, seminal vesicles, spermatic cord, and perineum may be involved when plexiform neurofibromas extend throughout the male pelvis.…”

Section: Neurofibroma and Plexiform Neurofibromamentioning

confidence: 99%

Abdominal Neoplasms in Patients with Neurofibromatosis Type 1: Radiologic-Pathologic Correlation

Levy¹,

Patel²,

Dow³

et al. 2005

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Neurofibromatosis type 1 (NF1) is one of the most common genetic disorders. NF1 is a complex disease resulting from a spectrum of mutations that may occur at many locations along the large, complex NF1 gene, which is located on chromosome 17. Mutations of the NF1 gene lead to abnormal tumor suppression. Consequently, patients with NF1 have an increased prevalence of benign and malignant neoplasms throughout the body. There are five categories of NF1 tumors that occur in the abdomen: neurogenic, neuroendocrine, nonneurogenic gastrointestinal mesenchymal, embryonal, and miscellaneous. Many of these tumors are age related, occur at specific anatomic locations, and have unique imaging features. Notably, many patients have a variety of organs affected because there is a high prevalence of multiple tumors occurring in the same patient. Neurofibromas are the most common benign neoplasms and may occur in the retroperitoneum or visceral organs. Malignant peripheral nerve sheath tumor is an aggressive malignancy that is the most common malignant tumor of the abdomen in patients with NF1. Interpreting abdominal imaging studies in patients with NF1 can be challenging because of the wide spectrum and diverse nature of tumors that occur in this disease.

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Section: Neurofibroma and Plexiform Neurofibromamentioning

confidence: 99%

Abdominal Neoplasms in Patients with Neurofibromatosis Type 1: Radiologic-Pathologic Correlation

Levy¹,

Patel²,

Dow³

et al. 2005

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“…In 1936, McDonnell [6] described a 37-year-old man who had a neurofibroma of the bladder, prostate, seminal vesicles, penis, and urethra. Pessin and Bodian [7] suggested that genitourinary involvement by neurofibroma originates from the vesicoprostatic plexus in males and the uretero-vaginal plexus in females. These plexuses are anatomically contiguous with the distal ureters, and if genital involvement is present, the bladder and lower ureters are also commonly affected [8].…”

Section: Discussionmentioning

confidence: 99%

Chronic renal failure and macrogenitalia associated with genitourinary neurofibromatosis

et al. 2010

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Neurofibromatosis (NF) is a genetic disorder of the nervous system that primarily affects the development and growth of neural cell tissues. This disorder is characterized by the development of various tumors, including neurofibromas, neuroniomas, malignant and benign peripheral nerve sheath tumors, and meningiomas. Accompanying skin changes and bone deformities are also common in NF. However, genitourinary involvement in NF is a rare condition, and penile enlargement has been reported only in a few males with plexiform NF. We report a 6-year-old boy with chronic renal failure associated with plexiform neurofibromas of the bladder and prostatic urethra which led to urinary obstruction and macrogenitalia due to genitourinary NF.

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“…Neurofibromas may originate from the pelvic autonon'tic plexus and lead to upper and lower urinary tract obstruction because of their anatomic location [4]. These plexiform neurofibromas can become very large and involve local structures.…”

Section: Discussionmentioning

confidence: 99%

MRI of pelvic neurofibromatosis

et al. 1995

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Pelvic neurofibromatosis is a rare disease and rarely involves the prostate. A 19-year-old male presented with irritative and obstructive voiding symptoms. Magnetic resonance imaging showed a large mass extending from the sacral promontory to the perirectal and perivesical spaces and to the proximal root of the penis. The mass also involved the prostate. The characteristics of the mass were highly suggestive for neurofibroma. Prostate biopsy showed neurofibroma, and the immunohistochemistry stain for S-100 protein was positive.

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Neurofibromatosis of the Pelvic Autonomic Plexuses

Cited by 38 publications

References 13 publications

Abdominal Neoplasms in Patients with Neurofibromatosis Type 1: Radiologic-Pathologic Correlation

Abdominal Neoplasms in Patients with Neurofibromatosis Type 1: Radiologic-Pathologic Correlation

Chronic renal failure and macrogenitalia associated with genitourinary neurofibromatosis

MRI of pelvic neurofibromatosis

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