Summary Fluvial landforms and deposits provide one of the most readily studied Quaternary continental records, and alluvial strata represent an important component in most ancient continental interior and continental margin successions. Moreover, studies of the long‐term dynamics of fluvial systems and their responses to external or ‘allogenic' controls, can play important roles in research concerning both global change and sequence‐stratigraphy, as well as in studies of the dynamic interactions between tectonic activity and surface processes. These themes were energized in the final decades of the twentieth century, and may become increasingly important in the first decades of this millennium. This review paper provides a historical perspective on the development of ideas in the fields of geomorphology/Quaternary geology vs. sedimentary geology, and then summarizes key processes that operate to produce alluvial stratigraphic records over time‐scales of 103−106 years. Of particular interest are changes in discharge regimes, sediment supply and sediment storage en route from source terrains to sedimentary basins, as well as changes in sea‐level and the concept of accommodation. Late Quaternary stratigraphic records from the Loire (France), Mississippi (USA), Colorado (Texas, USA) and Rhine–Meuse (The Netherlands) Rivers are used to illustrate the influences of climate change on continental interior rivers, as well as the influence of interacting climate and sea‐level change on continental margin systems. The paper concludes with a look forward to a bright future for studies of fluvial response to climate and sea‐level change. At present, empirical field‐based research on fluvial response to climate and sea‐level change lags behind: (a) the global change community's understanding of the magnitude and frequency of climate and sea‐level change; (b) the sequence‐stratigraphic community's desire to interpret climate and, especially, sea‐level change as forcing mechanisms; and (c) the modelling community's ability to generate numerical and physical models of surface processes and their stratigraphic results. A major challenge for the future is to catch up, which will require the development of more detailed and sophisticated Quaternary stratigraphic, sedimentological and geochronological frameworks in a variety of continental interior and continental margin settings. There is a particular need for studies that seek to document fluvial responses to allogenic forcing over both shorter (102−103 years) and longer (104−106 years) time‐scales than has commonly been the case to date, as well as in larger river systems, from source to sink. Studies of Quaternary systems in depositional basin settings are especially critical because they can provide realistic analogues for interpretation of the pre‐Quaternary rock record.

Part of the Earth Sciences CommonsThis Article is brought to you for free and open access by the Earth and Atmospheric Sciences, Department of at DigitalCommons@University of Nebraska -Lincoln. It has been accepted for inclusion in Papers in the Earth and Atmospheric Sciences by an authorized administrator of DigitalCommons@University of Nebraska -Lincoln. AbstractSequence stratigraphy emphasizes facies relationships and stratal architecture within a chronological framework. Despite its wide use, sequence stratigraphy has yet to be included in any stratigraphic code or guide. This lack of standardization reflects the existence of competing approaches (or models) and confusing or even conflicting terminology. Standardization of sequence stratigraphy requires the definition of the fundamental model-independent concepts, units, bounding surfaces and workflow that outline the foundation of the method. A standardized scheme needs to be sufficiently broad to encompass all possible choices of approach, rather than being limited to a single approach or model.A sequence stratigraphic framework includes genetic units that result from the interplay of accommodation and sedimentation (i.e., forced regressive, lowstand and highstand normal regressive, and transgressive), which are bounded by "sequence stratigraphic" surfaces. Each genetic unit is defined by specific stratal stacking patterns and bounding surfaces, and consists of a tract of correlatable depositional systems (i.e., a "systems tract"). The mappability of systems tracts and sequence stratigraphic surfaces depends on depositional setting and the types of data available for analysis. It is this high degree of variability in the precise expression of sequence stratigraphic units and bounding surfaces that requires the adoption of a methodology that is sufficiently flexible that it can accommodate the range of likely expressions. The integration of outcrop, core, well-log and seismic data affords the optimal approach to the application of sequence stratigraphy. Missing insights from one set of data or another may limit the "resolution" of the sequence stratigraphic interpretation. 1 2 c a t u n e a n u e t a l . i n e a r t h -science r e v i e w s 92 (2009)

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The lower Mississippi valley contains multiple large braid belts for which age control has been limited. Application of the optically stimulated luminescence technique has produced a new chronology of lower Mississippi valley channel-belt formation and insight into the valley's evolution during the last glacial cycle. Fluvial deposits range from last interglacial meander belts (85 ± 7 to 83 ± 7 ka) to multiple braid belts (64 ± 5 to 11 ± 1 ka) and record large-amplitude responses of the Mississippi River to glacially induced changes in discharge and sediment supply during the last glacial cycle. Slackwater deposits in buried tributary valleys from the middle Mississippi valley and northern lower Mississippi valley suggest that the river was fl owing at a position 8-21 m below the present fl ood plain during the last interglacial, then rapidly aggraded and switched to a braided regime to form the highest and oldest braid belt by 64 ± 5 to 50 ± 4 ka, coincident with initial glaciation of the upper drainage basin. The Mississippi River remained braided until fi nal meltwater withdrawal from its headwaters in the earliest Holocene. Braid-belt formation and incision was controlled by fl uctuations in meltwater and sediment discharge, while glacio-eustatic sea level controlled the elevation to which the river was graded, causing late glacial braid belts to dip below the Holocene fl ood plain in the southern lower Mississippi valley. Moreover, avulsions in the middle Mississippi valley and northern lower Mississippi valley during the last glaciation have pinned the river over regions of shallow bedrock, preventing the modern river from incising to its last interglacial profi le. The new chronology and longitudinal profi les presented here provide insight into the response of this continental-scale river system to climatic (glacial) and base-level forcing during the last 100 k.y. glacial cycle.

In the last 5 years, regulatory agencies and drug monitoring centres have been developing computerised data-mining methods to better identify reporting relationships in spontaneous reporting databases that could signal possible adverse drug reactions. At present, there are no guidelines or standards for the use of these methods in routine pharmaco-vigilance. In 2003, a group of statisticians, pharmaco-epidemiologists and pharmaco-vigilance professionals from the pharmaceutical industry and the US FDA formed the Pharmaceutical Research and Manufacturers of America-FDA Collaborative Working Group on Safety Evaluation Tools to review best practices for the use of these methods.In this paper, we provide an overview of: (i) the statistical and operational attributes of several currently used methods and their strengths and limitations; (ii) information about the characteristics of various postmarketing safety databases with which these tools can be deployed; (iii) analytical considerations for using safety data-mining methods and interpreting the results; and (iv) points to consider in integration of safety data mining with traditional pharmaco-vigilance methods. Perspectives from both the FDA and the industry are provided. Data mining is a potentially useful adjunct to traditional pharmaco-vigilance methods. The results of data mining should be viewed as hypothesis generating and should be evaluated in the context of other relevant data. The availability of a publicly accessible global safety database, which is updated on a frequent basis, would further enhance detection and communication about safety issues.

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