Multiple and dependent scattering effects in Doppler optical coherence tomography

Kalkman, Jeroen; Bykov, Alexander; Faber, Dirk J.; Leeuwen, Ton G. van

doi:10.1364/oe.18.003883

Cited by 54 publications

(50 citation statements)

References 24 publications

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“…Intralipid is an aqueous suspension of polydisperse lipid droplets, which is often used as a tissue phantom for optical measurements. Recently we showed that for high Intralipid concentrations multiple and dependent scattering effects play an important role and lead to nonlinear changes in the scattering coefficient with concentration [11]. To avoid these effects, measurements with low concentrations Intralipid (0.63, 1.25 and 2.5 wt.%) are performed.…”

Section: Scattering Samplesmentioning

confidence: 99%

“…The scattering anisotropy plays an important role in diffusive light transport, for example in diffuse reflectance spectroscopy. Also in OCT, g plays an important role as it determines the amount of backscattering and in the quantification of multiple scattering effects in (Doppler) OCT [11]. The possibility to extract g from OCT measurements is very attractive, because, in comparison with commonly used goniometric or integrating sphere methods, the non-invasive nature of OCT allows for in-vivo application.…”

Section: Introductionmentioning

confidence: 99%

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Determination of the scattering anisotropy with optical coherence tomography

Kodach¹,

Faber²,

Marle³

et al. 2011

Opt. Express

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Abstract:In this work we demonstrate measurements with optical coherence tomography (OCT) of the scattering phase function in the backward direction and the scattering anisotropy parameter g. Measurements of the OCT attenuation coefficient and the backscattering amplitude are performed on calibrated polystyrene microspheres with a time-domain OCT system. From these measurements the phase function in the backward direction is determined. The measurements are described by the single scattering model and match Mie calculations very well. Measurements on Intralipid demonstrate the ability to determine the g of polydisperse samples and, for Intralipid, g = 0.35 ± 0.03 is measured, which is well in agreement with g from literature. These measurements are validated using the Intralipid particle size distribution determined from TEM measurements. Measurements of g and the scattering phase function in the backward direction can be used to monitor changes in backscattering, which can indicate morphological changes of the sample or act as contrast enhancement mechanism.

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Section: Scattering Samplesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Determination of the scattering anisotropy with optical coherence tomography

Kodach¹,

Faber²,

Marle³

et al. 2011

Opt. Express

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“…14 More recently, Mie theory and the extended Huygens-Fresnel (EHF) model have been used to model scattering. [15][16][17][18] These models have enabled quantification of tissue optical properties and highlight the non-linearity of OCT signal with increasing scatterer concentration. However, these models require the adjustment of many parameters and are limited in fundamental physical scope by the assumptions of Mie scattering.…”

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confidence: 99%

Quantitative contrast-enhanced optical coherence tomography

Winetraub

SoRelle

Liba

et al. 2016

Applied Physics Letters

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We have developed a model to accurately quantify the signals produced by exogenous scattering agents used for contrast-enhanced Optical Coherence Tomography (OCT). This model predicts distinct concentration-dependent signal trends that arise from the underlying physics of OCT detection. Accordingly, we show that real scattering particles can be described as simplified ideal scatterers with modified scattering intensity and concentration. The relation between OCT signal and particle concentration is approximately linear at concentrations lower than 0.8 particle per imaging voxel. However, at higher concentrations, interference effects cause signal to increase with a square root dependence on the number of particles within a voxel. Finally, high particle concentrations cause enough light attenuation to saturate the detected signal. Predictions were validated by comparison with measured OCT signals from gold nanorods (GNRs) prepared in water at concentrations ranging over five orders of magnitude (50 fM to 5 nM). In addition, we validated that our model accurately predicts the signal responses of GNRs in highly heterogeneous scattering environments including whole blood and living animals. By enabling particle quantification, this work provides a valuable tool for current and future contrast-enhanced in vivo OCT studies. More generally, the model described herein may inform the interpretation of detected signals in modalities that rely on coherence-based detection or are susceptible to interference effects. V C 2016 AIP Publishing LLC.

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“…1. Light from a broadband source (B&W Tek superluminescent diode, λ c ¼ 1300 nm, 40 nm FWHM, 7 mW output power) is coupled, via an optical circulator (Gould Fiber Optics), into a 90=10 beam splitter with polarization controllers positioned in both the sample and reference arms [10]. The backreflected light is redirected through the optical circulator and coupled into the input waveguide of the AWG spectrometer.…”

mentioning

confidence: 99%

Spectral domain optical coherence tomography imaging with an integrated optics spectrometer

et al. 2011

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Spectral domain optical coherence tomography imaging with an integrated optics spectrometer Nguyen, V.D.; Akca, B.I.; Wörhoff, K.; de Ridder, R.M.; Pollnau, M.; van Leeuwen, T.G.; Kalkman, J. General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. 20, 2011; revised March 3, 2011; accepted March 10, 2011; posted March 10, 2011 (Doc. ID 141269); published March 31, 2011We designed and fabricated an arrayed-waveguide grating (AWG) in silicon oxynitride as a spectrometer for spectral domain optical coherence tomography (SD-OCT). The AWG has a footprint of only 3:0 cm × 2:5 cm, operates at a center wavelength of 1300 nm, and has 78 nm free spectral range. OCT measurements are performed that demonstrate imaging up to a maximum depth of 1 mm with an axial resolution of 19 μm, both in agreement with the AWG design parameters. Using the AWG spectrometer combined with a fiber-based SD-OCT system, we demonstrate crosssectional OCT imaging of a multilayered scattering phantom.

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Multiple and dependent scattering effects in Doppler optical coherence tomography

Cited by 54 publications

References 24 publications

Determination of the scattering anisotropy with optical coherence tomography

Determination of the scattering anisotropy with optical coherence tomography

Quantitative contrast-enhanced optical coherence tomography

Spectral domain optical coherence tomography imaging with an integrated optics spectrometer

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