Determination of the scattering anisotropy with optical coherence tomography

Kodach, Vitali M.; Faber, Dirk J.; Marle, J. van; Leeuwen, Ton G. van; Kalkman, Jeroen

doi:10.1364/oe.19.006131

Cited by 64 publications

(41 citation statements)

References 23 publications

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“…Moreover, the scattering coefficient and the anisotropy of highly scattering medium can be determined by optical coherence tomography (OCT). 29 Thus we could combine the photoacoustic imaging and OCT for simultaneous determination of absorption coefficient of heterogeneous absorbers and the optical scattering properties of the background.…”

Section: Discussionmentioning

confidence: 99%

Determination of optical absorption coefficient with focusing photoacoustic imaging

Zeng

et al. 2012

J. Biomed. Opt.

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Absorption coefficient of biological tissue is an important factor for photothermal therapy and photoacoustic imaging. However, its determination remains a challenge. In this paper, we propose a method using focusing photoacoustic imaging technique to quantify the target optical absorption coefficient. It utilizes the ratio of the amplitude of the peak signal from the top boundary of the target to that from the bottom boundary based on wavelet transform. This method is self-calibrating. Factors, such as absolute optical fluence, ultrasound parameters, and Grüneisen parameter, can be canceled by dividing the amplitudes of the two peaks. To demonstrate this method, we quantified the optical absorption coefficient of a target with various concentrations of an absorbing dye. This method is particularly useful to provide accurate absorption coefficient for predicting the outcomes of photothermal interaction for cancer treatment with absorption enhancement.

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Section: Discussionmentioning

confidence: 99%

Determination of optical absorption coefficient with focusing photoacoustic imaging

Zeng

et al. 2012

J. Biomed. Opt.

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“…Both μ B and μ s are proportional to the phase function 23,26 integrated over scattering angles (0 to π) and [π-arctan numerical aperture (NA) to π], respectively. Furthermore, the ratio μ B ∕μ s ¼ p NA is the probability that light will be scattered into the NA of the OCT objective lens.…”

Section: Theorymentioning

confidence: 99%

“…Therefore, if the shape of the phase function is known, g can also be determined. 26,27 The dominance of either scattering or absorption is described by the albedo, 28 a ¼ μ s ∕ðμ a þ μ s Þ such that a ¼ 0 indicates pure absorption and a ¼ 1 indicates purely scattering. In applications such as ophthalmology, the operating waveband of OCT can be chosen to minimize optical absorption, 29 leading to the assumptions that a ≈ 1 and, therefore, μ OCT ≈ μ s while maintaining a useful imaging depth.…”

Section: Theorymentioning

confidence: 99%

Dynamic measurement of the optical properties of bovine enamel demineralization models using four-dimensional optical coherence tomography

et al. 2017

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Abstract. Dental enamel mineral loss is multifactorial and is consequently explored using a variety of in vitro models. Important factors include the presence of acidic pH and its specific ionic composition, which can both influence lesion characteristics. Optical coherence tomography (OCT) has been demonstrated as a promising tool for studying dental enamel demineralization. However, OCT-based characterization and comparison of demineralization model dynamics are challenging without a consistent experimental environment. Therefore, an automated four-dimensional OCT system was integrated with a multispecimen flow cell to measure and compare the optical properties of subsurface enamel demineralization in different models. This configuration was entirely automated, thus mitigating any need to disturb the specimens and ensuring spatial registration of OCT image volumes at multiple time points. Twelve bovine enamel disks were divided equally among three model groups. The model demineralization solutions were citric acid (pH 3.8), acetic acid (pH 4.0), and acetic acid with added calcium and phosphate (pH 4.4). Bovine specimens were exposed to the solution continuously for 48 h. Three-dimensional OCT data were obtained automatically from each specimen at a minimum of 1-h intervals from the same location within each specimen. Lesion dynamics were measured in terms of the depth below the surface to which the lesion extended and the attenuation coefficient. The net loss of surface enamel was also measured for comparison. Similarities between the dynamics of each model were observed, although there were also distinct characteristic differences. Notably, the attenuation coefficients showed a systematic offset and temporal shift with respect to the different models. Furthermore, the lesion depth curves displayed a discontinuous increase several hours after the initial acid challenge. This work demonstrated the capability of OCT to distinguish between different enamel demineralization models by making dynamic quantitative measurements of lesion properties. This has important implications for future applications in clinical dentistry. © The Authors.Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…Modern optics can provide realtime imaging of human tissues with resolutions that are comparable to that of histopathology, as well as having the potential ability to reveal biochemical and/or molecular information. [13][14][15] The scattering properties of the tissue depend on the difference of refractive index-matching between the cells and extracellular fluid. 7 Optical coherence tomography (OCT), a noninvasive technology for microstructure imaging of biological tissues, has been used to quantify the permeability of a hyperosmotic agent in atherosclerotic vascular tissue, cancerous gastric tissue, breast cancer tissue, and sclera and skin tissues ex vivo and in vivo.…”

Section: Introductionmentioning

confidence: 99%

Ex vivodetermination of glucose permeability and optical attenuation coefficient in normal and adenomatous human colon tissues using spectral domain optical coherence tomography

et al. 2012

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Recent reports have suggested that spectral domain optical coherence tomography (SD-OCT) is a useful tool for quantifying the permeability of hyperosmotic agents in various tissues. We report our preliminary results on quantification of glucose diffusion and assessment of the optical attenuation change due to the diffusion of glucose in normal and adenomatous human colon tissues in vitro by using a SD-OCT and then calculated the permeability coefficients (PC) and optical attenuation coefficients (AC). The PC of a 30% aqueous solution of glucose was 3.37±0.23×10⁻⁶ cm/s in normal tissue and 5.65±0.16×10⁻⁶ cm/s in cancerous colon tissue. Optical AC in a normal colon ranged from 3.48±0.37 to 2.68±0.82 mm⁻¹ and was significantly lower than those seen in the cancerous tissue (8.48±0.95 to 3.16±0.69 mm⁻¹, p<0.05). The results suggest that quantitative measurements of using PC and AC from OCT images could be a potentially powerful method for colon cancer detection.

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Determination of the scattering anisotropy with optical coherence tomography

Cited by 64 publications

References 23 publications

Determination of optical absorption coefficient with focusing photoacoustic imaging

Determination of optical absorption coefficient with focusing photoacoustic imaging

Dynamic measurement of the optical properties of bovine enamel demineralization models using four-dimensional optical coherence tomography

Ex vivodetermination of glucose permeability and optical attenuation coefficient in normal and adenomatous human colon tissues using spectral domain optical coherence tomography

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