Multinucleate Cell Angiohistiocytoma of the Orbit

Shields, Jerry A.; Eagle, Ralph C.; Shields, Carol L.; Sohmer, Kenette K.

doi:10.1016/s0002-9394(14)72178-6

Cited by 15 publications

(14 citation statements)

References 4 publications

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“…It develops insidiously over several months or years. Common sites of involvement include the distal extremities, especially the dorsal hands, wrists, thighs and legs, but it may also be seen on the forehead, cheeks, orbit, lower lid, upper lip, and trunk, as in our case. Rarely, there is involvement of the oral mucosa .…”

Section: Discussionmentioning

confidence: 55%

Multinucleate cell angiohistiocytoma with hypertrophic nerves

et al. 2013

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Multinucleate cell angiohistiocytoma (MCAH) represents a rare benign skin lesion characterized by multiple papules that are usually found on the distal extremities or face of middle-aged women. We report on a 60-year-old male with a history of monoclonal gammopathy and severe rheumatoid arthritis who had several asymptomatic red-to-livid papules grouped on the right side of his trunk. The lesions had been present for a few years and were gradually enlarging. Biopsies from three lesions showed a spectrum of changes consisting of a proliferation of small venules together with thickened collagen bundles and increased numbers of interstitial cells including bizarre, multinucleated giant cells. Immunohistochemically, the multinucleated cells were positive for vimentin and lysozyme while the interstitial cells expressed CD68, factor XIIIa and lysozyme. Interestingly, strikingly enlarged dermal nerves were seen in all the three biopsies and two of the biopsies showed an accompanying infiltrate of lymphocytes and plasma cells.

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Section: Discussionmentioning

confidence: 55%

Multinucleate cell angiohistiocytoma with hypertrophic nerves

et al. 2013

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“…Multinucleate cell angiohistiocytoma (MCAH) is an uncommon benign soft‐tissue tumour, first described by Smith and Wilson‐Jones 1 . Although an overwhelming majority of these tumours have been described on the skin of the limbs, 2–8 lesions have also been diagnosed on the skin of the temple, 5 chest, 6 face and trunk, 7 eyelid 9 and vermilion of the lip 10 . To our knowledge, this is the first report of a mucosal MCAH.…”

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confidence: 89%

“…MCAH is more commonly seen in women. The skin on the limbs is most commonly affected, 2–8 but lesions affecting the face, 7 chest, 6 trunk, 7 temple, 5 lip, 10 and eyelid 9 have also been described. The differential diagnosis includes nodular, lichen planus, lymphocytic infiltrates, annular sarcoid granuloma, angiohistiocytoma, Kaposi’s and pseudo‐Kaposi’s sarcomas.…”

Section: Reportmentioning

confidence: 99%

Multinucleate cell angiohistiocytoma: an uncommon mucosal tumour

Rawal¹,

Anderson²,

Rawal

2009

Clinical and Experimental Dermatology

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Multinucleate cell angiohistiocytoma (MCAH) is an uncommon benign soft-tissue lesion with characteristic histological and immunohistochemical features. It is unclear if it represents a benign neoplasm or a reactive/inflammatory process. The overwhelming majority of these tumors have been described on cutaneous surfaces. One case has been reported on the skin of the lip. This is the first documentation of MCAH within the oral cavity. The clinical presentation, histopathological features and immunohistochemical reactivity pattern are described. Because of the benign nature of this lesion, a conservative approach is recommended in its management. Surgical excision appears to be curative.

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“…in middle‐aged to elderly women. Although the majority of these tumors have been described on the limbs, lesions have also been reported to distribute on the temple, face, eyelids, mucosa and vermilion of the lips . The arrangement of lesions tends to be solitary, multiple or grouped and shows a tendency to be unilateral.…”

mentioning

confidence: 99%