Multinucleate cell angiohistiocytoma: an uncommon mucosal tumour

Abstract

Multinucleate cell angiohistiocytoma (MCAH) is an uncommon benign soft-tissue lesion with characteristic histological and immunohistochemical features. It is unclear if it represents a benign neoplasm or a reactive/inflammatory process. The overwhelming majority of these tumors have been described on cutaneous surfaces. One case has been reported on the skin of the lip. This is the first documentation of MCAH within the oral cavity. The clinical presentation, histopathological features and immunohistochemical reactivity pattern are described. Because of the benign nature of this lesion, a conservative approach is recommended in its management. Surgical excision appears to be curative.

Multiple asymptomatic papules on the dorsum of hands

“…[1][2][3][4][5][6] It typically presents during mid-adulthood, and has a female predilection. [1][2][3][4][5][6] It typically presents during mid-adulthood, and has a female predilection.…”

“…[1][2][3][4][5][6] Clinically, MCAH usually occurs as multiple, dome-shaped or flat, pink to red-brown or violaceous papules 2-15 mm in size, most commonly involving the legs or the dorsum of hands. [2][3][4][5][6] Although most cases are reported to have slow growth over several months to years before stabilizing, few lesions have regressed spontaneously. [2][3][4][5][6] Although most cases are reported to have slow growth over several months to years before stabilizing, few lesions have regressed spontaneously.…”

“…[2][3][4][5][6] Although most cases are reported to have slow growth over several months to years before stabilizing, few lesions have regressed spontaneously. [2][3][4][5][6] Immunohistochemically, the endothelial cells lining the blood vessels express several endothelial markers including Factor VIII-related antigen and CD31. A vascular or fibrohistiocytic origin has been suggested based on immunohistochemical and ultrastructural studies.…”

Novel Case of Generalized Multinucleate Cell Angiohistiocytoma

“…It is a benign fibrohistiocytic and vascular proliferation that characteristically presents with solitary firm, red to brown or violaceous papules. [1][2][3][4] The lesions may also form nodules or relatively large plaques. 5 Although they may cause pruritus, the lesions are usually asymptomatic.…”

“…3 Most commonly, they are distributed over the distal extremities, including the hands, wrists, and legs; however, they have been reported on the trunk, face, and oral mucosa. 3,4 The lesions can be solitary or multiple. When there are multiple lesions, they are often grouped, can be in an annular or linear arrangement, and may be bilateral.…”