Generalized multinucleate cell angiohistiocytoma: case report and literature review

Wang, Ming; Abdul‐fattah, Bilal; Wang, Cuiyan; Zhao, Yun; Qu, Xiaolei; Al-Muriesh, Maher; Wang, Xia; Zhu, Li; Yue, Qian; Huang, Changzheng; Chen, Siyuan

doi:10.1111/cup.12853

Cited by 13 publications

(31 citation statements)

References 28 publications

(42 reference statements)

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“…For example, MCAH does not show the dense granulomatous inflammation expected in the first two entities nor the prominent vessels with hemosiderin deposition seen in acroangiodermatitis . Lesional analysis of Kaposi sarcoma does not show multinucleate giant cells, and immunohistochemistry would reveal HHV‐8 positivity . Instead, MCAH pathology reveals an upper‐to‐mid‐dermal proliferation of narrow vessels within thickened collagen bundles, as well as large angulated multinucleate giant cells with palisading nuclei and eosinophilic cytoplasm .…”

Section: Discussionmentioning

confidence: 98%

“…Moreover, there is no current consensus as to the etiopathogenesis of the multinucleate giant cells in MCAH. Equivocal positivity for monocytic/macrophage lineage markers including CD68 detracts from the proposition that these multinucleate cells represent degenerated macrophages . Ongoing discussion considers whether MCAH may represent a variant of dermatofibroma.…”

Section: Discussionmentioning

confidence: 99%

“…MCAH is an uncommon vascular fibrohistiocytic proliferation that often presents as grouped red‐purple papules and nodules . Lesions typically arise on the dorsal hands and lower extremities .…”

Section: Discussionmentioning

confidence: 99%

“…Lesions typically arise on the dorsal hands and lower extremities . Localized, multifocal, and generalized variants have been reported; the localized variant is most common and best‐described . There is an overwhelming female predilection for localized and multifocal lesions; on the other hand, the generalized variant shows no significant gender tendency …”

Section: Discussionmentioning

confidence: 99%

“…Since the first description of MCAH in 1985, multiple hypotheses regarding etiology and pathogenesis have been proposed . It is generally favored that these lesions arise as a reactive rather than a neoplastic process . Several reports of spontaneous remission further support the reactive hypothesis .…”

Section: Discussionmentioning

confidence: 99%

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Multinucleate cell angiohistiocytoma: Case report and literature review

et al. 2018

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Multinucleate cell angiohistiocytoma is a rare, vascular, fibrohistiocytic proliferation that has a benign but progressive course. The clinical presentation is that of grouped red‐purple papules and nodules characteristically located on the lower extremities in women. The histopathology shows a proliferation of narrow vessels within thickened collagen bundles associated with multinucleate giant cells. These lesions are probably reactive in nature, and several mechanisms of pathogenesis, including hormonal, have been proposed. Different modalities, including intense pulsed light and pulsed‐dye laser, have been used for treatment of these lesions. We report a case of a 74‐year‐old Caucasian woman with long‐standing multinucleate angiohistiocytoma on her bilateral thighs that eluded diagnosis for several years. Upon biopsy and histopathological analysis, the diagnosis was made. Treatment options were entertained, although ultimately not pursued by the patient. We report this case to increase clinical awareness of this rare disease and to contribute to the ongoing literature aimed to further characterize this condition.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations