Multinational study of major breast milk carotenoids of healthy mothers

Canfield, Louise M.; Clandinin, Michael T.; Davies, David; Fernández, Maria Candelaria de León; Jackson, Joan G.; Hawkes, Jo; Goldman, William J.; Pramuk, Kathryn; Reyes, Horacio; Sablan, Benjamin; Sonobe, Tomoyoshi; Xu, Bo

doi:10.1007/s00394-003-0403-9

Cited by 112 publications

(116 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The baseline concentrations in breast milk of the major carotenoids are in agreement with some previous reports (34). However, in other studies (26), total lutein + zeaxanthin, lycopene, and β-cryptoxanthin concentrations were lower and α-carotene concentrations were higher, whereas the concentration of β-carotene was similar to that in the current study. It is likely that the increased variability in the collection time in Canfield et al (26) (1–12 mo postpartum) resulted in the difference in our study with a more discrete period of 2–3 mo postpartum.…”

Section: Discussionsupporting

confidence: 76%

“…The range of lutein + zeaxanthin intake was large, and those with the highest intakes reported consuming dark, leafy greens, mainly spinach, on the majority of the self-reported 3-d food records. The distribution of carotenoids in breast milk was different than in the U.S. population in a previous multinational study, which reported β-carotene as the most abundant carotenoid in breast milk and lutein as the most abundant in the diet (26). The current study demonstrates that, at baseline, total lutein + zeaxanthin was the most abundant carotenoid in breast milk and lycopene was the most abundant carotenoid in the diet followed by β-carotene.…”

Section: Discussionmentioning

confidence: 59%

“…The current study demonstrates that, at baseline, total lutein + zeaxanthin was the most abundant carotenoid in breast milk and lycopene was the most abundant carotenoid in the diet followed by β-carotene. Canfield et al (26) did not report lycopene in the diet, so it is unclear how the dietary intakes in these study populations differ. The baseline concentrations in breast milk of the major carotenoids are in agreement with some previous reports (34).…”

Section: Discussionmentioning

confidence: 91%

“…Although the specific transport mechanism has not yet been fully elucidated, carotenoids tend to be found in higher concentrations in early milk (<3 mo postpartum) when lipid concentrations are lower (25). The relation between intake and concentration may be culturally dependent, because a study of breast milk from women in 9 countries showed that women in China and Japan have the highest breast milk lutein + zeaxanthin concentrations, which are 3 times higher than those in women from the United Kingdom, the United States, and Australia (26). Because placental and breast milk lutein are dependent on maternal consumption, which is low in the United States, understanding the impact of lutein supplementation and the effects on the mother and infant is important.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Lutein Supplementation Increases Breast Milk and Plasma Lutein Concentrations in Lactating Women and Infant Plasma Concentrations but Does Not Affect Other Carotenoids

Sherry

Oliver

Renzi

et al. 2014

The Journal of Nutrition

View full text Add to dashboard Cite

Lutein is a carotenoid that varies in breast milk depending on maternal intake. Data are lacking with regard to the effect of dietary lutein supplementation on breast milk lutein concentration during lactation and subsequent plasma lutein concentration in breast-fed infants. This study was conducted to determine the impact of lutein supplementation in the breast milk and plasma of lactating women and in the plasma of breast-fed infants 2–3 mo postpartum. Lutein is the dominant carotenoid in the infant brain and the major carotenoid found in the retina of the eye. Eighty-nine lactating women 4–6 wk postpartum were randomly assigned to be administered either 0 mg/d of lutein (placebo), 6 mg/d of lutein (low-dose), or 12 mg/d of lutein (high-dose). The supplements were consumed for 6 wk while mothers followed their usual diets. Breast milk carotenoids were measured weekly by HPLC, and maternal plasma carotenoid concentrations were measured at the beginning and end of the study. Infant plasma carotenoid concentrations were assessed at the end of the study. No significant differences were found between dietary lutein + zeaxanthin intake and carotenoid concentrations in breast milk and plasma or body mass index at baseline. Total lutein + zeaxanthin concentrations were greater in the low- and high-dose–supplemented groups than in the placebo group in breast milk (140% and 250%, respectively; P < 0.0001), maternal plasma (170% and 250%, respectively; P < 0.0001), and infant plasma (180% and 330%, respectively; P < 0.05). Lutein supplementation did not affect other carotenoids in lactating women or their infants. Lactating women are highly responsive to lutein supplementation, which affects plasma lutein concentrations in the infant. This trial was registered at clinicaltrials.gov as NCT01747668.

show abstract

Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Lutein Supplementation Increases Breast Milk and Plasma Lutein Concentrations in Lactating Women and Infant Plasma Concentrations but Does Not Affect Other Carotenoids

Sherry

Oliver

Renzi

et al. 2014

The Journal of Nutrition

View full text Add to dashboard Cite

show abstract

“…In contrast to breast milk, infant formulas contain only minor quantities of lutein. High-performance liquid chromatography (HPLC) studies yield levels from 0.07 to 0.13 µg/L [8]. As a result, a number of infant formula manufacturers have recently developed lutein-fortified formulas.…”

Section: Introductionmentioning

confidence: 99%

Growth and Tolerance Assessment of a Lutein-fortified Infant Formula

Kon

Gmoshinskaya

Safronova

et al. 2014

Pediatr Gastroenterol Hepatol Nutr

View full text Add to dashboard Cite

PurposeTo evaluate safety, gastrointestinal tolerance, and growth of a new experimental starter formula (NESF) fortified with lutein, prebiotics, probiotics, nucleotides and beta-carotene, fed to infants within the first months of life.MethodsThis was a non-randomized, open, uncontrolled study conducted from December 2010 to May 2011. Twenty-three healthy infants aged 10 days to 2 months old were enrolled. Outcomes included gastrointestinal tolerance, physical growth and safety. Prior to the initiation of the trial, the Scientific Research Institute of Nutrition of the Russian Academy of Medical Sciences confirmed that the NESF met all safety and nutritional parameters.ResultsNESF was well tolerated. The majority of infants fed this formula passed semi-liquid, yellow or yellow-brown. The mean stool frequency/day was 2.5±0.4 on study-day 14 and 1.8±0.5 on study-day 28. The mean daily weight gain was 30.9±3.8 grams and the mean length gain during the 28 days of follow up was 3.1±0.8 cm, corresponding to the average physical growth normally seen in the first months of life in Russian infants. Six children left the study: one refused to drink the formula, one left the study as parents changed residence; and one child's parents have recalled their informed consent due to adverse event unrelated to the product. Three infants presented adverse events possibly related to the product (rash; colic and abdominal pain; constipation). Seventeen infants completed the trial.ConclusionThis study demonstrated that lutein-fortified formula is safe, well-tolerated and supported physical growth of evaluated infants.

show abstract

Vitamin A

Solomons¹

2012

Present Knowledge in Nutrition

View full text Add to dashboard Cite

Multinational study of major breast milk carotenoids of healthy mothers

Cited by 112 publications

References 24 publications

Lutein Supplementation Increases Breast Milk and Plasma Lutein Concentrations in Lactating Women and Infant Plasma Concentrations but Does Not Affect Other Carotenoids

Lutein Supplementation Increases Breast Milk and Plasma Lutein Concentrations in Lactating Women and Infant Plasma Concentrations but Does Not Affect Other Carotenoids

Growth and Tolerance Assessment of a Lutein-fortified Infant Formula

Vitamin A

Contact Info

Product

Resources

About