Multimodal therapy strategies based on hydrogels for the repair of spinal cord injury

Wang, Yan; Lv, Hongqian; Chao, Xuan; Xu, Wenxin; Liu, Yun; Ling, Guixia; Zhang, Peng

doi:10.1186/s40779-022-00376-1

Cited by 20 publications

(7 citation statements)

References 82 publications

(127 reference statements)

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“…Neuroplasticity can also manifest in the central nervous system post-injury via the mechanism of cortical remapping, where functions lost as a result to CNS damage is remapped to another part of the cerebral cortex [55]. In the repair of spinal cord injury, hydrogels have mechanical properties that mimic the extracellular matrix of the spinal cord, providing a scaffold for axonal growth and neuronal formation, removal of inflammatory cells and factors, eliminating spinal cord cyst formation, and inhibition of glial scarring [56]. Advances in organ regeneration and healing can revolutionize treatment modalities and optimise patient care.…”

Section: Advances In Organ Regenerationmentioning

confidence: 99%

Pushing the frontiers of military medical excellence: updates, progress and future needs

Seah

Wang

2022

Military Med Res

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Since its establishment in 2014, MilitaryMedicalResearch has come a long way in becoming a premier journal for scientific articles from various different specialties, with a special emphasis on topics with military relevance. The field of military medicine may be obscure, and may not be readily encountered by the typical clinician on a day-to-day basis. This journal aims not only to pursue excellence in military research, but also keep current with the latest advancements on general medical topics from each and every specialty. This editorial serves to recap and synthesize the existing progress, updates and future needs of military medical excellence, discussing foremostly the unique traits of literature published in this journal, and subsequently presenting the discourse regarding wartime and peacetime medicine, the role of the military in a public health emergency, as well as wound healing and organ regeneration. Special attention have been devoted to military topics to shed light on the effects of Chemical, Biological, Radiological and Explosive (CBRE) warfare, environmental medicine and military psychiatry, topics which rarely have a chance to be discussed elsewhere. The interconnectedness between military combat and soldier physical and mental well-being is intricate, and has been distorted by pandemics such as coronavirus disease 2019 (COVID-19). This journal has come a long way since its first article was published, steadily contributing to the existing knowledge pool on general medical topics with a military slant. Only with continuous research and sharing, can we build upon the work of the scientific community, with hopes for the betterment of patient care.

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Section: Advances In Organ Regenerationmentioning

confidence: 99%

Pushing the frontiers of military medical excellence: updates, progress and future needs

Seah

Wang

2022

Military Med Res

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“…Studies have shown that using such carriers for transplanting neural stem/progenitor cells effectively promotes behavioral recovery in SCI rats ( Mothe et al, 2013 ). Hydrogels can be used as slow-release small-molecule drug reservoirs ( Wang et al, 2022 ). For instance, serpin delivered by a chitosan-collagen hydrogel demonstrated a prolonged therapeutic effect and facilitated functional recovery in SCI rats ( Kwiecien et al, 2020 ).…”

Section: Approaches For Spinal Cord Injury Treatmentmentioning

confidence: 99%

Application and prospects of somatic cell reprogramming technology for spinal cord injury treatment

Yang

Pan

Wang

et al. 2022

Front. Cell. Neurosci.

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Spinal cord injury (SCI) is a serious neurological trauma that is challenging to treat. After SCI, many neurons in the injured area die due to necrosis or apoptosis, and astrocytes, oligodendrocytes, microglia and other non-neuronal cells become dysfunctional, hindering the repair of the injured spinal cord. Corrective surgery and biological, physical and pharmacological therapies are commonly used treatment modalities for SCI; however, no current therapeutic strategies can achieve complete recovery. Somatic cell reprogramming is a promising technology that has gradually become a feasible therapeutic approach for repairing the injured spinal cord. This revolutionary technology can reprogram fibroblasts, astrocytes, NG2 cells and neural progenitor cells into neurons or oligodendrocytes for spinal cord repair. In this review, we provide an overview of the transcription factors, genes, microRNAs (miRNAs), small molecules and combinations of these factors that can mediate somatic cell reprogramming to repair the injured spinal cord. Although many challenges and questions related to this technique remain, we believe that the beneficial effect of somatic cell reprogramming provides new ideas for achieving functional recovery after SCI and a direction for the development of treatments for SCI.

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“…Primary spinal cord injury resulting in axonal disruption, neural tissue destruction and neuronal death, with partial functional repair primarily through surgical decompression and spinal fixation (Antar et al, 2018;Huang et al, 2022). Secondary injuries are long-term progressive injuries that occur after the primary injury resulting in lesion spread and stage destruction, including neuronal/axonal loss, formation of a neuroregenerative inhibitory microenvironment and glial scarring (Doherty et al, 2002;Wang et al, 2022). However, the death of motor neurons, interneurons, and glial cells at the site of the lesion owing to subsequent damage predisposes to a decrease in muscle tissue mass and fiber cross-sectional fiber diameter, resulting in a loss of function (Liu X. et al, 2021;Fouad et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Worldwide productivity and research trend of publications concerning electroactive materials and spinal cord injury: A bibliometric study

Liu

Song²,

Dai³

et al. 2023

Front. Bioeng. Biotechnol.

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Purpose: We investigated the current state and trends in the area during the previous 10 years using bibliometric approaches to evaluate the global scientific output of research on electroactive materials and spinal cord injury.Methods: Studies on spinal cord injury in electroactive materials that were published between 2012 and 2022 were located using the Web of science (WOS) datebase. The software programs bibliometrix R-package and CiteSpace were used to do quantitative analyses of annual publications, nation, author, institution, journal source, co-cited references, and keywords. The studies were categorized by the research’s main points using a qualitative analysis, and publications having more than 10 citations each year.Results: In the final analysis, 1,330 relevant papers or reviews were included. There is an increased tendency in both the average annual citation rate and the number of publications in the discipline. The United States and the University of Toronto are the countries and institutions that have contributed the most to this discipline, respectively. The majority of authors are from the China and United States. Zhang Y is the author with the most published articles and holds the top position in the cited author h-index species. The journal with the highest number of published articles is “Disability and rehabilitation”; the journal is divided into four main areas including physics, materials, chemistry, molecular, and biology. The keyword analysis revealed a shift in research hotspots from schwann cell, fracture, and urinary disorders to carbon-based materials, functional recovery, and surgery. Analysis of qualitative data revealed that the role and mechanism of injectable conductive hydrogels in spinal cord healing after damage is a hot topic of current study, with the mechanism primarily focusing on the inhibition of oxidative stress (Nrf2) and apoptosis (Casepase 3).Conclusion: Our bibliometric analysis indicates that research on electroactive materials for spinal cord injury remains an active field of study. Moreover, contemporary research is concentrated on carbon-based materials, functional rehabilitation, and surgery.

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Multimodal therapy strategies based on hydrogels for the repair of spinal cord injury

Cited by 20 publications

References 82 publications

Pushing the frontiers of military medical excellence: updates, progress and future needs

Pushing the frontiers of military medical excellence: updates, progress and future needs

Application and prospects of somatic cell reprogramming technology for spinal cord injury treatment

Worldwide productivity and research trend of publications concerning electroactive materials and spinal cord injury: A bibliometric study

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