Multimodal P3 under different attentional states in mesial temporal lobe epilepsy

Trinka, Eugen; Unterrainer, Josef M.; Luef, Gerhard; Ladurner, G.

doi:10.1046/j.1468-1331.2001.00214.x

Cited by 8 publications

(5 citation statements)

References 52 publications

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“…Event-related potential (ERP) is an important method to evaluate the cognitive status of epilepsy patients (e.g., Sunaga et al, 1994;Soysal et al, 1999;Rodin et al, 1999;Tendon and Duban, 2000;Trinka et al, 2000;Sun et al, 2007). Differences in timing and scalp topography of particular ERP components allow inferences about the timing and spatial characteristics of brain activity involved in cognitive processing (Rugg and Coles, 1995).…”

Section: Introductionmentioning

confidence: 99%

Attention changes in epilepsy patients following 3-month topiramate or valproate treatment revealed by event-related potential

Sun

Wang

et al. 2008

International Journal of Psychophysiology

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Section: Introductionmentioning

confidence: 99%

Attention changes in epilepsy patients following 3-month topiramate or valproate treatment revealed by event-related potential

Sun

Wang

et al. 2008

International Journal of Psychophysiology

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“…The earliest identified member of this family, auditory ERP-P300, is used as an objective criterion for evaluating cognitive functions. Clinical studies showed delayed and smaller P300 in epileptics compared with controls; irregular waves can also be observed in those patients (Soysal et al, 1999;Rodin et al, 1999;Trinka et al, 2001). In the traditional auditory oddball paradigm, P300 is elicited by an event that is both infrequent and task relevant.…”

mentioning

confidence: 99%

Antiepileptic Drugs and the Significance of Event-Related Potentials

Sun

Wang²,

Wu³

et al. 2007

Journal of Clinical Neurophysiology

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The authors compared cognitive changes in epilepsy patients with or without antiepileptic drugs using event-related potential (ERP) N270 and P300. The patients were divided into three groups according to treatment type: carbamazepine, valproate acid (VPA), or no treatment. One control group composed of healthy subjects was included. The Mini-Mental State Examination detected no clinical dementia in all subjects. A modified Sternberg paradigm was used as a task when an ERP was recorded. When a stimulus was different from the memorized item (conflict condition), N270 was elicited in both controls and patients. All the three patient groups showed a delayed and smaller N270 than the control group. P300 was elicited when a stimulus was the same one as the memorized item (match condition), and its amplitude decreased in the VPA group. P300 latency did not differ among the four groups. ERP (N270 and P300) was abnormal in patients with epilepsy. These results indicate that antiepileptic drugs, especially VPA, might enhance the impairment of cognitive processing. N270 is more sensitive than P300 in the early detection of minor cognitive impairment in epileptics.

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“…This result suggests that the neural function of MTS patients does not contribute the neural synchrony necessary for the detection of subtle electrophysiological events. This finding was further supported by studies showing electrophysiologic abnormalities in event-related potentials (ERPs) recorded from patients with MTS 29 , which were not observed using a similar paradigm in the visual modality 30 .…”

Section: Discussionmentioning

confidence: 56%

Temporal resolution in individuals with neurological disorders

Rabelo

Weihing

Schochat

2015

Clinics

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OBJECTIVE:Temporal processing refers to the ability of the central auditory nervous system to encode and detect subtle changes in acoustic signals. This study aims to investigate the temporal resolution ability of individuals with mesial temporal sclerosis and to determine the sensitivity and specificity of the gaps-in-noise test in identifying this type of lesion.METHOD:This prospective study investigated differences in temporal resolution between 30 individuals with normal hearing and without neurological lesions (G1) and 16 individuals with both normal hearing and mesial temporal sclerosis (G2). Test performances were compared, and the sensitivity and specificity were calculated.RESULTS:There was no difference in gap detection thresholds between the two groups, although G1 revealed better average thresholds than G2 did. The sensitivity and specificity of the gaps-in-noise test for neurological lesions were 68% and 98%, respectively.CONCLUSIONS:Temporal resolution ability is compromised in individuals with neurological lesions caused by mesial temporal sclerosis. The gaps-in-noise test was shown to be a sensitive and specific measure of central auditory dysfunction in these patients.

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Multimodal P3 under different attentional states in mesial temporal lobe epilepsy

Abstract: The results suggest a modality dependence of the P3 component in patients with mTLE. The novelty processing of auditory stimuli is disturbed in patients with right sided mTLE.

Cited by 8 publications

References 52 publications

Attention changes in epilepsy patients following 3-month topiramate or valproate treatment revealed by event-related potential

Attention changes in epilepsy patients following 3-month topiramate or valproate treatment revealed by event-related potential

Antiepileptic Drugs and the Significance of Event-Related Potentials

Temporal resolution in individuals with neurological disorders

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