Attention changes in epilepsy patients following 3-month topiramate or valproate treatment revealed by event-related potential

Sun, Wei; Wang, Yuping; Wang, Weiwei; Wu, Xun

doi:10.1016/j.ijpsycho.2008.02.003

Cited by 27 publications

(24 citation statements)

References 33 publications

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“…Ebner et al 26 affirm that the latency increased and the amplitude reduction can be related to neurophysiological alterations and not only and necessarily associate to a cerebral disorder as showed in this study, probably because cognitive functions reflected with P300 latencies decline in relation with duration and frequency of every kind of seizure, AEDs and seizure types as shown by Sun et al 27 . Some authors believe that the seizure frequency can negatively affect cognitive functions.…”

Section: Side Groupssupporting

confidence: 71%

Electrophysiological and auditory behavioral evaluation of individuals with left temporal lobe epilepsy

Rocha

Miziara

Manreza

et al. 2010

Arq. Neuro-Psiquiatr.

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The purpose of this study was to determine the repercussions of left temporal lobe epilepsy (TLE) for subjects with left mesial temporal sclerosis (LMTS) in relation to the behavioral testDichotic Digits Test (DDT), event-related potential (P300), and to compare the two temporal lobes in terms of P300 latency and amplitude. We studied 12 subjects with LMTS and 12 control subjects without LMTS. Relationships between P300 latency and P300 amplitude at sites C3A1,C3A2,C4A1, and C4A2, together with DDT results, were studied in inter-and intra-group analyses. On the DDT, subjects with LMTS performed poorly in comparison to controls. This difference was statistically significant for both ears. The P300 was absent in 6 individuals with LMTS. Regarding P300 latency and amplitude, as a group, LMTS subjects presented trend toward greater P300 latency and lower P300 amplitude at all positions in relation to controls, difference being statistically significant for C3A1 and C4A2. However, it was not possible to determine laterality effect of P300 between affected and unaffected hemispheres. Key words: epilepsy, event-related potentials P300, mesial temporal sclerosis.Avaliação eletrofisiológica e comportamental da audição em individuos com epilepsia em lobo temporal esquerdo resumo O objetivo deste estudo foi determinar a repercussão da epilepsia de lobo temporal esquerdo (LTE) em indivíduos com esclerose mesial temporal esquerda (EMTE) em relação à avaliação auditiva comportamental-Teste Dicótico de Dígitos (TDD), ao Potencial Evocado Auditivo de Longa Latência (P300) e comparar o P300 do lobo temporal esquerdo e direito. Estudamos 12 indivíduos com EMTE (grupo estudo) e 12 indivíduos controle com desenvolvimento típico. Analisamos as relações entre a latência e amplitude do P300, obtidos nas posições C3A1,C3A2,C4A1 e C4A2 e os resultados obtidos no TDD. No TDD, o grupo estudo apresentou pior desempenho em relação ao grupo controle, sendo esta diferença estatisticamente significante em ambas as orelhas. Para o P300, observamos que em seis indivíduos com EMTE o potencial foi ausente. Para a latência e amplitude, verificamos que estes indivíduos apresentaram uma tendência ao aumento da latência e redução da amplitude para todas as posições em relação ao grupo controle, sendo estatisticamente significante em C3A1 e C4A2. Contudo, não foi possível determinar efeito de lateralidade do P300 entre o hemisfério afetado e não-afetado. Palavras-chave: epilepsia, potencial evocado P300, esclerose mesial temporal.

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Section: Side Groupssupporting

confidence: 71%

Electrophysiological and auditory behavioral evaluation of individuals with left temporal lobe epilepsy

Rocha

Miziara

Manreza

et al. 2010

Arq. Neuro-Psiquiatr.

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“…Cognitive side effects can include impaired concentration [Froscher et al 2005], cognitive dulling [Coppola et al 2002], psychomotor slowing [Tatum et al 2001], language and comprehension problems [Fritz et al 2005], detrimental effects on short-term memory [Gomer et al 2007;Aldenkamp et al 2000] and working memory [Jung et al 2010;Lee et al 2006;Fritz et al 2005], poor verbal fluency [Jung et al 2010;Gomer et al 2007;Lee et al 2006Lee et al , 2003Fritz et al 2005;Thompson et al 2000] and wordfinding deficits [Mula et al 2003b], reduced IQ score [Sun et al 2008;Lee et al 2003;Thompson et al 2000] and cognitive speed [Bootsma et al 2008a;Gomer et al 2007], and abnormal thinking [Froscher et al 2005]. Other studies report improvements in cognitive measures after topiramate withdrawal [Kockelmann et al 2003].…”

Section: Pregabalinmentioning

confidence: 99%

The cognitive impact of antiepileptic drugs

Eddy¹,

Rickards²,

Cavanna³

2011

Ther Adv Neurol Disord

318

189

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Effective treatment of epilepsy depends on medication compliance across a lifetime, and studies indicate that drug tolerability is a significant limiting factor in medication maintenance. Available antiepileptic drugs (AEDs) have the potential to exert detrimental effects on cognitive function and therefore compromise patient wellbeing. On the other hand, some agents may serve to enhance cognitive function. In this review paper, we highlight the range of effects on cognition linked to a variety of newer and older AEDs, encompassing key alterations in both specific executive abilities and broader neuropsychological functions. Importantly, the data reviewed suggest that the effects exerted by an AED could vary depending on both patient characteristics and drug-related variables. However, there are considerable difficulties in evaluating the available evidence. Many studies have failed to investigate the influence of patient and treatment variables on cognitive functioning. Other difficulties include variation across studies in relation to design, treatment group and assessment tools, poor reporting of methodology and poor specification of the cognitive abilities assessed. Focused and rigorous experimental designs including a range of cognitive measures assessing more precisely defined abilities are needed to fill the gaps in our knowledge and follow up reported patterns in the literature. Longitudinal studies are needed to improve our understanding of the influence of factors such as age, tolerance and the stability of cognitive effects. Future trials comparing the effects of commonly prescribed agents across patient subgroups will offer critical insight into the role of patient characteristics in determining the cognitive impact of particular AEDs.

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“…Different substances that cause addiction, from alcohol and nicotine to various opiates, lead to changes in cognitive functions, including changes in P300 parameters, due to brain damage (54)(55)(56)(57)(58)(59)(60). Moreover, with P300 testing, damage of cognitive functions resulting from taking different medicines, especially antiepileptic drugs, can also be monitored (61)(62)(63). Additionally, P300 characteristics help diagnosing cognitive damage resulting from systemic diseases, such as anaemia, uremia (renal insufficiency), hepatic encephalopathy, systemic lupus erythematosus, diabetes mellitus, hypothyreosis, as well as COPD (64)(65)(66)(67)(68)(69)(70)(71)(72)(73)(74)(75)(76).…”

Section: Discussionmentioning

confidence: 99%

“…Isolated research has been performed on CEP P300 in patients with epilepsy taking different antiepileptic drugs, such as: topiramate, valproate, and lamotrigine (61)(62)(63). These studies were based on measuring and comparing CEP P300 parameters while the patients were taking the drugs.…”

Section: Review Of Literaturementioning

confidence: 99%

P300 as an auxiliary method in clinical practice: A review of literature

Titlić

Mihalj

Petrovic

et al. 2016

JHSCI

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Cognitive functions can be assessed and followed up over a period of time with cognitive evoked potentials (CEP) P300� In this context, brainstem auditory evoked potentials (BAEP) are most commonly used, but visual evoked potentials (VEP) are utilized as well� The research in this area has demonstrated that these techniques could be used as a supplemental method in diagnostics of numerous diseases such as Alzheimer's disease, mild cognitive impairment, vascular dementia, epilepsy, craniocerebral trauma, Parkinson's disease, multiple sclerosis, and other degenerative diseases� In addition, P300 can also be used as an auxiliary method in the diagnostics of mental disorders conditions such as schizophrenia, panic disorders, narcotic drug addiction, nicotinism, alcoholism, etc� The method assists in monitoring the course of diseases leading to encephalopathy, such as liver and kidney damage and grave anaemia� The advantages of P300 testing are easy application, non-invasiveness, and an unlimited number of potential applications� Moreover, the results obtained with this method are measurable and can be compared�

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Attention changes in epilepsy patients following 3-month topiramate or valproate treatment revealed by event-related potential

Cited by 27 publications

References 33 publications

Electrophysiological and auditory behavioral evaluation of individuals with left temporal lobe epilepsy

Electrophysiological and auditory behavioral evaluation of individuals with left temporal lobe epilepsy

The cognitive impact of antiepileptic drugs

P300 as an auxiliary method in clinical practice: A review of literature

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