Multimodal Molecular Imaging: Current Status and Future Directions

Wu, Min; Shu, Jiwu

doi:10.1155/2018/1382183

Cited by 94 publications

(95 citation statements)

References 165 publications

(132 reference statements)

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“…Molecular imaging enables the quantitative characterization and measurement of biological diagnosis at the cellular and molecular level, which will inevitably advance the modern and future medical imaging and diagnosis (Wu and Shu, 2018;. However, the current critical issue lies in developing novel and appropriate contrast agents to meet the biological compatibility for different species (Basal et al, 2017).…”

Section: Prospects and Challengesmentioning

confidence: 99%

Recent Advances of Bioresponsive Nano-Sized Contrast Agents for Ultra-High-Field Magnetic Resonance Imaging

2020

Front. Chem.

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Section: Prospects and Challengesmentioning

confidence: 99%

Recent Advances of Bioresponsive Nano-Sized Contrast Agents for Ultra-High-Field Magnetic Resonance Imaging

2020

Front. Chem.

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“…These advances have provided both temporal and spatial information of experimental HSCT that no other technique could provide. In addition, molecular imaging involves a set of noninvasive techniques that allow a serial analysis of the same individual, thereby significantly decreasing the number of animals used for experimentation [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

“…BLI generally provides high sensitivity with a high signal-to-noise ratio when compared to fluorescent imaging [35]; moreover, its tissue penetrability in higher than that of fluorescence imaging [14,36], and has a high throughput for imaging of small animals [9,15], as also a wide temporal detection window (0 days to 1 year) [9], despite its use being limited to preclinical studies. In vivo BLI enables real-time monitoring of gene expression and cell fate through visual representation of the bioluminescence generated by oxidation of specific substrates by luciferase enzymes, providing a dynamic profile of engraftment and proliferation in live recipient animals [9,37].…”

Section: Introductionmentioning

confidence: 99%

“…However, the HSCT tracking time depends on the radioisotope half-life, resulting in a small temporal window in signal detection. These techniques have good sensitivity, high penetration without depth limit, and can be translated into clinical practice, but they have a low spatial resolution, require the use of ionizing radiation, and have a high cost [14,42,43].…”

Section: Introductionmentioning

confidence: 99%

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Noninvasive Tracking of Hematopoietic Stem Cells in a Bone Marrow Transplant Model

Oliveira

Nucci

Filgueiras

et al. 2020

Cells

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The hematopoietic stem cell engraftment depends on adequate cell numbers, their homing, and the subsequent short and long-term engraftment of these cells in the niche. We performed a systematic review of the methods employed to track hematopoietic reconstitution using molecular imaging. We searched articles indexed, published prior to January 2020, in PubMed, Cochrane, and Scopus with the following keyword sequences: (Hematopoietic Stem Cell OR Hematopoietic Progenitor Cell) AND (Tracking OR Homing) AND (Transplantation). Of 2191 articles identified, only 21 articles were included in this review, after screening and eligibility assessment. The cell source was in the majority of bone marrow from mice (43%), followed by the umbilical cord from humans (33%). The labeling agent had the follow distribution between the selected studies: 14% nanoparticle, 29% radioisotope, 19% fluorophore, 19% luciferase, and 19% animal transgenic. The type of graft used in the studies was 57% allogeneic, 38% xenogeneic, and 5% autologous, being the HSC receptor: 57% mice, 9% rat, 19% fish, 5% for dog, porcine and salamander. The imaging technique used in the HSC tracking had the following distribution between studies: Positron emission tomography/single-photon emission computed tomography 29%, bioluminescence 33%, fluorescence 19%, magnetic resonance imaging 14%, and near-infrared fluorescence imaging 5%. The efficiency of the graft was evaluated in 61% of the selected studies, and before one month of implantation, the cell renewal was very low (less than 20%), but after three months, the efficiency was more than 50%, mainly in the allogeneic graft. In conclusion, our review showed an increase in using noninvasive imaging techniques in HSC tracking using the bone marrow transplant model. However, successful transplantation depends on the formation of engraftment, and the functionality of cells after the graft, aspects that are poorly explored and that have high relevance for clinical analysis.

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“…There is an increasing demand for precision medicine in which a doctor takes into account the individual patient's genotypes and phenotypic expressions . In addition to the Omics techniques that are becoming an integral part of standard tests for patient care, molecular imaging technologies are also used to provide in vivo evaluation of diagnosis, disease progression, and targeted therapy . The value of molecular imaging technologies for guiding therapeutic intervention is currently under evaluation in numerous clinical trials for a broad range of diseases .…”

Section: Introductionmentioning

confidence: 99%

Feasibility study of a point‐of‐care positron emission tomography system with interactive imaging capability

Jiang

Komarov

et al. 2019

Medical Physics

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Purpose: We investigated the feasibility of a novel positron emission tomography (PET) system that provides near real-time feedback to an operator who can interactively scan a patient to optimize image quality. The system should be compact and mobile to support point-of-care (POC) molecular imaging applications. In this study, we present the key technologies required and discuss the potential benefits of such new capability. Methods: The core of this novel PET technology includes trackable PET detectors and a fully threedimensional, fast image reconstruction engine implemented on multiple graphics processing units (GPUs) to support dynamically changing geometry by calculating the system matrix on-the-fly using a tube-of-response approach. With near real-time image reconstruction capability, a POC-PET system may comprise a maneuverable front PET detector and a second detector panel which can be stationary or moved synchronously with the front detector such that both panels face the region-of-interest (ROI) with the detector trajectory contoured around a patient's body. We built a proof-of-concept prototype using two planar detectors each consisting of a photomultiplier tube (PMT) optically coupled to an array of 48 9 48 lutetium-yttrium oxyorthosilicate (LYSO) crystals (1.0 9 1.0 9 10.0 mm 3 each). Only 38 9 38 crystals in each arrays can be clearly re-solved and used for coincidence detection. One detector was mounted to a robotic arm which can position it at arbitrary locations, and the other detector was mounted on a rotational stage. A cylindrical phantom (102 mm in diameter, 150 mm long) with nine spherical lesions (8:1 tumor-to-background activity concentration ratio) was imaged from 27 sampling angles. List-mode events were reconstructed to form images without or with time-of-flight (TOF) information. We conducted two Monte Carlo simulations using two POC-PET systems. The first one uses the same phantom and detector setup as our experiment, with the detector coincidence re-solving time (CRT) ranging from 100 to 700 ps full-width-at-half-maximum (FWHM). The second study simulates a body-size phantom (316 9 228 9 160 mm 3 ) imaged by a larger POC-PET system that has 4 9 6 modules (32 9 32 LYSO crystals/module, four in axial and six in transaxial directions) in the front panel and 3 9 8 modules (16 9 16 LYSO crystals/module, three in axial and eight in transaxial directions) in the back panel. We also evaluated an interactive scanning strategy by progressively increasing the number of data sets used for image reconstruction. The updated images were analyzed based on the number of data sets and the detector CRT. Results: The proof-of-concept prototype re-solves most of the spherical lesions despite a limited number of coincidence events and incomplete sampling. TOF information reduces artifacts in the reconstructed images. Systems with better timing resolution exhibit improved image quality and reduced artifacts. We observed a reconstruction speed of 0.96 9 10 6 events/s/iteration for 600 9 600 9 224 voxel rect...

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Multimodal Molecular Imaging: Current Status and Future Directions

Cited by 94 publications

References 165 publications

Recent Advances of Bioresponsive Nano-Sized Contrast Agents for Ultra-High-Field Magnetic Resonance Imaging

Recent Advances of Bioresponsive Nano-Sized Contrast Agents for Ultra-High-Field Magnetic Resonance Imaging

Noninvasive Tracking of Hematopoietic Stem Cells in a Bone Marrow Transplant Model

Feasibility study of a point‐of‐care positron emission tomography system with interactive imaging capability

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